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Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models

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Abstract

Aiming the ‘Bridge to Recovery’ course, we have developed a novel left ventricular assist device (LVAD) controlling system. It can change the rotational speed of the continuous flow LVAD, EVAHEART, synchronized with the cardiac beat. Employing this system, we have already demonstrated that myocardial oxygen consumption (MVO2), which is considered to be equivalent to native heart load, changes in the hearts of normal goats. Herein, we examined changes in goats with acute ischemic heart failure. We studied 14 goats (56.1 ± 6.9 kg) with acute ischemic heart failure due to coronary microsphere embolization. We installed the EVAHEART and drive in four modes: “circuit-clamp”, “continuous support”, “counter-pulse”, and “co-pulse”, with 50 and 100 % bypass. In comparison to the circuit-clamp mode, MVO2 was reduced to 70.4 ± 17.9 % in the counter-pulse mode and increased to 90.3 ± 14.5 % in the co-pulse mode, whereas it was 80.0 ± 14.5 % in the continuous mode, with 100 % bypass (p < 0.05). The same difference was confirmed with 50 % bypass. This means that we may have a chance to change the native heart load by controlling the LVAD rotation in synchrony with the cardiac rhythm, so we named our controller as the Native Heart Load Control System (NHLCS). Employing changeable MVO2 with NHLCS according to the patient’s condition may provide more opportunity for native heart recovery with LVAD, especially for patients with ischemic heart diseases.

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Authors and Affiliations

  1. Department of Cardiothoracic Surgery, The University of Tokyo, Tokyo, Japan

    Akihide Umeki, Takashi Nishimura, Masahiko Ando, Shunei Kyo & Minoru Ono

  2. Department of Artificial Organ, National Cerebral and Cardiovascular Center, Suita, Japan

    Akihide Umeki, Yoshiaki Takewa, Mamoru Arakawa, Yuichiro Kishimoto, Tomonori Tsukiya, Toshihide Mizuno, Yoshiyuki Taenaka & Eisuke Tatsumi

  3. Department of Therapeutic Strategy for Heart Failure, The University of Tokyo, 7-3-1 Hongo, Bunkyou-ku, Tokyo, Japan

    Takashi Nishimura & Shunei Kyo

  4. Department of Cardiothoracic Surgery, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Takashi Nishimura & Shunei Kyo

  5. 5-8-7-104 Honkomagome, Bunkyou-ku, Tokyo, Japan

    Akihide Umeki

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  1. Akihide Umeki
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  2. Takashi Nishimura
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  3. Yoshiaki Takewa
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  4. Masahiko Ando
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Correspondence to Akihide Umeki or Takashi Nishimura.

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Umeki, A., Nishimura, T., Takewa, Y. et al. Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models. J Artif Organs 16, 119–128 (2013). https://doi.org/10.1007/s10047-012-0682-0

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