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Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function

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Abstract

The purpose of this study was to examine the hemodynamic characteristics of expanded polytetrafluoroethylene (ePTFE) pulmonary valves with bulging sinuses quantitatively in a pediatric pulmonary mechanical circulatory system designed by us, in order to propose the optimal design for clinical applications. In this study, we developed a pediatric pulmonary mock circulation system, which consisted of a pneumatic right ventricular model, a pulmonary heart valve chamber, and a pulmonary elastic compliance tubing with resistive units. The hemodynamic characteristics of four different types of ePTFE valves and a monoleaflet mechanical heart valve were examined. Relationships between the leaflet movements and fluid characteristics were evaluated based on engineering analyses using echocardiography and a high-speed video camera under the pediatric circulatory conditions of the mock system. We successfully performed hemodynamic simulations in our pediatric pulmonary circulatory system that could be useful for quantitatively evaluating the pediatric heart valves. In the simulation study, the ePTFE valve with bulging sinuses exhibited a large eddy in the vicinity of the leaflets, whereas the straight tubing exhibited turbulent flow. The Reynolds number obtained in the valve with bulging sinuses was calculated to be 1667, which was smaller than that in the straight tubing (R e = 2454).

The hemodynamic characteristics of ePTFE pediatric pulmonary heart valves were examined in our mock circulatory system. The presence of the bulging sinuses in the pulmonary heart valve decreased the hydrodynamic energy loss and increased the systolic opening area. Based on an in vitro experiment, we were able to propose an optimal selection of pulmonary valve design parameters that could yield a more sophisticated pediatric ePTFE valve shape.

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Acknowledgments

This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (no. 22689047).

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Authors and Affiliations

  1. Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan

    Ichiro Suzuki, Shota Yabe, Yusuke Tsuboko, Telma Keiko Sugai, Yoshifumi Saijo & Makoto Yoshizawa

  2. Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan

    Yasuyuki Shiraishi, Ken Matsue, Takeyoshi Kameyama & Tomoyuki Yambe

  3. Waseda University TWIns, Tokyo, Japan

    Takashi Tanaka, Yoshihiro Okamoto & Mitsuo Umezu

  4. Department of Bio-System Engineering, Yamagata University, Yonezewa, Japan

    Zhonggang Feng

  5. Department of Pediatric Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Takako Miyazaki & Masaaki Yamagishi

Authors
  1. Ichiro Suzuki
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  2. Yasuyuki Shiraishi
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  3. Shota Yabe
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  4. Yusuke Tsuboko
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  5. Telma Keiko Sugai
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  6. Ken Matsue
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  7. Takeyoshi Kameyama
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  8. Yoshifumi Saijo
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  9. Takashi Tanaka
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  10. Yoshihiro Okamoto
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  11. Zhonggang Feng
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  12. Takako Miyazaki
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  13. Masaaki Yamagishi
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  14. Makoto Yoshizawa
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  15. Mitsuo Umezu
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  16. Tomoyuki Yambe
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Corresponding authors

Correspondence to Ichiro Suzuki or Yasuyuki Shiraishi.

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Suzuki, I., Shiraishi, Y., Yabe, S. et al. Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function. J Artif Organs 15, 49–56 (2012). https://doi.org/10.1007/s10047-011-0609-1

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  • DOI: https://doi.org/10.1007/s10047-011-0609-1

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