Abstract
Adverse events due to anticoagulation and antiplatelet therapy during left ventricular assistance device (LVAD) support are very common, and every effort must be made to reduce their impact. We report our experience using a low dose of double antiplatelet therapy for patients provided with the INCOR LVAD system as a bridge to transplantation. Twelve patients (10 males, 35–60 years old) with acute or end-stage heart failure were included in this study. The mean follow-up was 10 months (cumulative 4.9 years). For antiplatelet therapy, we use an association of variable doses of aspirin and clopidogrel. The use of a platelet aggregation test (PAT) allows reducing the dose of the drugs to the minimum needed. The primary end point was to check the safety of the therapy, analyzing the incidence of major and minor bleeding complications. The secondary end point was to check the effectiveness of the therapy, evaluating the incidence of major and minor thromboembolic events. We had three (25%) cases of early postoperative mediastinal bleeding. On the contrary, no episodes of major bleeding occurred during the follow-up period. The rate of minor bleeding complications was low: 0.2 events per patient/year. The rate of major and minor thromboembolic events was acceptable (respectively 0.09 and 0.2 per patient/year). During LVAD support, double antiplatelet therapy with a low dose of aspirin and clopidogrel was safe and effective. PAT allows reducing the dose of antiplatelet drugs, avoiding complications related to excessive or insufficient dose administration.
Similar content being viewed by others
References
Frazier OH, Rose EA, Oz MC, Dembitsky W, McCarthy P, Radovancevic B, Poirier VL, Dasse KA, Heart Mate LVAS Investigators. Left Ventricular Assist System. Multicenter clinical evaluation of the HeartMate vented electrical left ventricular assist system in patients awaiting heart transplantation. J Thorac Cardiovasc Surg 2001;122:1186–95.
McCarthy PM, Smedira NO, Vargo RL, Goormastic M, Hobbs RE, Starling RC, Young JB. One hundred patients with the Heartmate left ventricular assist device: evolving concepts and technology. J Thorac Cardiovasc Surg. 1998;115:904–12.
Schmid C, Jurmann M, Birnbaum D, Colombo T, Falk V, Feltrin G, Garatti A, Genoni M, Gerosa G, Göttel P, Gummert J, Halfmann R, Hammel D, Hennig E, Kaufmann F, Lanfranconi M, Meyns B, Mohr F, Müller J, Nikolov D, Rucinskas K, Scheld HH, Schmid FX, Schneider M, Sirvydis V, Tandler R, Vitali E, Vlasselaers D, Weyand M, Wilhelm M, Hetzer R. Influence of inflow cannula length in axial-flow pumps on the neurologic adverse event rate: results from a multicenter analysis. J Heart Lung Transplant. 2008;27:253–60.
Berlin Heart GmbH. The official site of the Berlin Heart: the heart support specialists. 2005–2009. http://www.berlinheart.com/englisch/medpro/incor/Pumpe. Accessed 24 Aug 2010.
Born GVR, Cross MJ. The aggregation of blood platelets. J Physiol. 1963;168:178–95.
Eichelberger JW. Kinetic (slope) measurement of platelet aggregation. Horsman: Bio/Data Corporation; 1984.
Triplett DA, editors. Platelet function: laboratory evaluation and clinical application. American Society of Clinical Pathologist, Chicago, IL; 1978.
William WJ, Beutler E, Erslev AJ, Rundles RW. Hematology. New York: Mcgraw-Hill 1977.
Bye A, Lewis Y, O’Grady J. Effect of a single oral dose of aspirin on the platelet aggregation response to arachidonic acid. Br J Clin Pharmacol. 1979;7a:293.
Day HJ, Holmsen H. Laboratory test of platelet function. Ann Clin Lab Sci. 1972;2:63.
Owen CA, Bowie EJW, Thompson JH. The diagnosis of bleeding disorder. Boston: Little, Brown and Co.; 1975.
Sweeny JM, Gorog DA, Fuster V. Antiplatelet drug ‘resistance’. Part 1: mechanisms and clinical measurements. Nat Rev Cardiol. 2009;6:273–82.
Etz C, Welp H, Rothenburger M, Tjan TD, Wenzelburger F, Schmid C. Analysis of platelet function during left ventricular support with the INCOR and EXCOR system. Heart Surg Forum. 2004;7:E423–7.
Holman WL, Pae WE, Teutenberg JJ, Acker MA, Naftel DC, Sun BC, Milano CA, Kirklin JK. INTERMACS: interval analysis of registry data. J Am Coll Surg. 2009;208:755–61. (discussion 761–2, Epub 2009 Feb 1).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Attisani, M., Centofanti, P., La Torre, M. et al. Safety and effectiveness of low dosing of double antiplatelet therapy during long-term left ventricular support with the INCOR system. J Artif Organs 13, 202–206 (2010). https://doi.org/10.1007/s10047-010-0527-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10047-010-0527-7