Abstract
The MCMS-0102 cardiac pacemaker for rapid ventricular pacing to induce heart failure in animals has been improved in terms of miniaturization and performance. To determine the performance of the new MCMS-0102, six devices were implanted in beagle dogs, and two of these devices were reimplanted for continued pacing in a total of eight beagle dogs. The hearts were paced at 260 beats per minute for 4 weeks (P group: n = 8). The hemodynamic status of the P group was examined and compared with nonpaced dogs (NP group: n = 8). The neurohumoral status of the P group was evaluated before and after rapid pacing. Stable operation of the six devices during rapid pacing was confirmed using the telemetry system. Postmortem examinations revealed features similar to clinical heart failure characterized by massive ascites, pleural effusion, cardiomegaly, and liver congestion in all the paced dogs. Cardiac output was 1.1 ± 0.2 l/min in the NP group and 0.5 ± 0.1 l/min in the P group (P < 0.0001). The left atrial pressure and the central venous pressure of the P group and the NP group were 23 ± 6 versus 6 ± 2 mmHg (P < 0.0001) and 10 ± 3 versus 4 ± 3 mmHg (P < 0.001), respectively. In the paced dogs, plasma renin activity increased from 0.5 ± 0.4 to 8.5 ± 7.4 ng/ml/h (P < 0.05) and atrial natriuretic peptide levels increased from 69 ± 41 to 229 ± 72 pg/ml (P < 0.001). The improved MCMS-0102 was successfully implanted in beagle dogs and it succeeded in inducing the congestive heart failure model.
Similar content being viewed by others
References
AJG Riegger G Liebau (1982) ArticleTitleThe renin-angiotensin-aldosterone system, antidiuretic hormone and sympathetic nerve activity in an experimental model of congestive heart failure in the dog Clin Sci 62 465–469 Occurrence Handle7075144 Occurrence Handle1:CAS:528:DyaL38XksFentLk%3D
PW Armstrong TP Stopps SE Ford AJ de Bold (1986) ArticleTitleRapid ventricular pacing in the dog: pathophysiologic studies of heart failure Circulation 74 1075–1084 Occurrence Handle2945673 Occurrence Handle1:STN:280:BiiD38fmsVc%3D
JR Wilson P Douglas WF Hickey V Lanoce N Ferrari A Muhammed N Reichek (1987) ArticleTitleExperimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects Circulation 75 857–867 Occurrence Handle3829344 Occurrence Handle1:STN:280:BiiC2MbptlI%3D
S Sasayama H Asanoi S Ishizaka (1991) ArticleTitleMechanics of contraction and relaxation of the ventricle in experimental heart failure produced by rapid ventricular pacing in the conscious dog Eur Heart J 12 IssueIDSuppl C 35–41 Occurrence Handle1915438 Occurrence Handle1:CAS:528:DyaK3MXmt1eisr4%3D
GW Moe C Angus RJ Howard TG Parker PW Armstrong (1992) ArticleTitleEvaluation of indices of left ventricular contractility and relaxation in evolving canine experimental heart failure Cardiovasc Res 26 362–366 Occurrence Handle1638568 Occurrence Handle1:STN:280:By2A2cnmsVQ%3D Occurrence Handle10.1093/cvr/26.4.362
HJ Patel EB Lankford DJ Polidori JJ Pilla T Plappert MSJ Sutton MA Acker (1997) ArticleTitleDynamic cardiomyoplasty: its chronic and acute effects on the failing heart J Thorac Cardiovasc Surg 114 169–178 Occurrence Handle9270632 Occurrence Handle1:STN:280:ByiH3MnmvVY%3D Occurrence Handle10.1016/S0022-5223(97)70141-7
A Wada T Tsutamoto M Ohnishi M Sawaki D Fukai Y Maeda M Kinoshita (1999) ArticleTitleEffects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure Circulation 99 570–577 Occurrence Handle9927406 Occurrence Handle1:CAS:528:DyaK1MXht1Gnsr0%3D
HH Chen JA Grantham JA Schirger M Jougasaki MM Redfield JC Burnett SuffixJr (2000) ArticleTitleSubcutaneous administration of brain natriuretic peptide in experimental heart failure J Am Coll Cardiol 36 1706–1712 Occurrence Handle11079680 Occurrence Handle1:CAS:528:DC%2BD3cXosFKgsb0%3D Occurrence Handle10.1016/S0735-1097(00)00911-6
BL Cmolik DR Thompson JT Sherwood AS Geha DT George (2001) ArticleTitleIncreased coronary artery blood flow with aortomyoplasty in chronic heart failure Ann Thorac Surg 71 284–289 Occurrence Handle11216762 Occurrence Handle1:STN:280:DC%2BD3M7kvFyisA%3D%3D Occurrence Handle10.1016/S0003-4975(00)02242-6
K Watanabe H Kuroda E Sato H Makino Y Hasegawa J Amano (2001) ArticleTitleHeart failure in the dog induced by rapid ventricular pacing using a newly designed cardiac pacemaker, MCMS-0102 J Artif Organs 4 231–236
HJ Patel JJ Pilla DJ Polidori SV Pusca TA Plappert MSJ Sutton EB Lankford MA Acker (2000) ArticleTitleTen weeks of rapid ventricular pacing creates a long-term model of left ventricular dysfunction J Thorac Cardiovasc Surg 119 835–841
FG Spinale M de Gasparo S Whitebread L Hebbar MJ Clair DM Melton RS Krombach R Mukherjee JP Iannini O SJ (1997) ArticleTitleModulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure. I Effects on left ventricular performance and neurohormonal systems Circulation 96 2385–2396 Occurrence Handle9337215 Occurrence Handle1:CAS:528:DyaK2sXmvVKrsLo%3D
SB Kribbs WM Merritt MJ Clair RS Krombach WV Houck MG Dodd R Mukherjee FG Spinale (1998) ArticleTitleAmlodipine monotherapy, angiotensin-converting enzyme inhibition, and combination therapy with pacing-induced heart failure Hypertension 31 755–765 Occurrence Handle9495258 Occurrence Handle1:CAS:528:DyaK1cXhsFekt74%3D
RB New AC Sampson MK King JW Hendrick MJ Clair JH McElmurray SuffixIII J Mandel R Mukherjee M de Gasparo FG Spinale (2000) ArticleTitleEffects of combined angiotensin II and endothelin receptor blockade with developing heart failure, effects on left ventricular performance Circulation 102 1447–1453 Occurrence Handle10993866 Occurrence Handle1:CAS:528:DC%2BD3cXntFKktrw%3D
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Watanabe, K., Kuroda, H., Sato, E. et al. In vivo evaluation of the improved MCMS-0102 pacemaker with a rapid pacing mode for induction of experimental heart failure in animals. J Artif Organs 9, 84–89 (2006). https://doi.org/10.1007/s10047-006-0328-1
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10047-006-0328-1