Skip to main content

Advertisement

Log in

Role of ventricular assist devices in the German heart allocation system

  • ORIGINAL ARTICLE
  • Published:
Journal of Artificial Organs Aims and scope Submit manuscript

Abstract

The Eurotransplant (ET) allocation algorithm, newly implemented in 2000, gives priority for heart transplantation (HTx) to patients with high urgency (HU) status, but now this status is rescinded upon ventricular assist device (VAD) implantation and only regained if severe complications occur during mechanical circulatory support (MCS). We studied the effects of this change on the patients in our institute who were waiting for HTx with MCS. The median duration of MCS until HTx in adult patients gradually increased from 3.1 months in 1994, reaching a peak of 16.7 months in 2000, and then gradually decreased to 6.0 months in 2003. Among the patients with VAD implantation as a bridge to HTx, two patients were on MCS for more than 1 year (the longest duration of MCS being 1.6 years) at the end of 1999, and this figure increased to nine patients and a maximum MCS duration of 3.7 years at the end of 2003. These data imply that the patients in whom a complication occurred in the early phase of MCS and who had overcome this complication underwent HTx early with HU status, and those who were stable during MCS waited a long time for HTx. Furthermore, the number of patients in the latter group is increasing. The new allocation algorithm imposes on patients with MCS waiting for HTx who are relatively young and free from complications and serious coexisting disease, very long-term MCS without an end to VAD bridging, which is almost equivalent to destination therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Eurotransplant International Foundation. Thoracic allocation system (EThAS). ET manual. Available at: http://www.eurotransplant.nl/

  2. MC Deng JM De Meester JM Smits J Heinecke HH Scheld InstitutionalAuthorNameComparative Outcome and Clinical Profiles in Transplantation (COCPIT) Study Group (2000) ArticleTitleEffect of receiving a heart transplant: analysis of a national cohort entered on to a waiting list, stratified by heart failure severity BMJ 321 540–545 Occurrence Handle10.1136/bmj.321.7260.540 Occurrence Handle1:STN:280:DC%2BD3cvmvF2iuw%3D%3D Occurrence Handle10968814

    Article  CAS  PubMed  Google Scholar 

  3. Richtlinien zur Organtransplantation gemäß §16 Transplantationsgesetz. Duetsches Ärzteblatt 2000;97:A396–A411

    Google Scholar 

  4. Gesetz über die Spende, Entnahme und Übertragung von Organen (Transplantationsgesetz – TPG) Vom 5. November 1997. Bundesgesetzblatt 1997 Teil I Seite 2631

  5. A Tuffs (2000) ArticleTitleGermany introduces new criteria for organ allocation BMJ 320 10

    Google Scholar 

  6. M Schaafsma M Possemis (2000) ArticleTitleNational allocation rules within Eurotransplant Erotransplant Newsletter 162 4–6

    Google Scholar 

  7. InstitutionalAuthorNameEuropean Transplant Coordinators Organization (1999) ArticleTitleInternational figures on 1998 organ donation and transplantation activities Organs Tissues 3 142–145

    Google Scholar 

  8. Deutsche Stiftung Organtransplantation. Zahlen und Daten. Organtransplantationen. Available at: http://www.dso.de/

  9. LW Stevenson MA Hamilton IH Tillisch JD Moriguchi JA Kobashigawa JA Creaser D Drinkwater H Laks (1991) ArticleTitleDecreasing survival benefit from cardiac transplantation for outpatients as the waiting list lengthens J Am Coll Cardiol 18 919–925 Occurrence Handle1:STN:280:By6A2sznsFU%3D Occurrence Handle1894865

    CAS  PubMed  Google Scholar 

  10. MC Deng JM De Meester HH Scheld (2000) ArticleTitleDevelopment of cardiac transplant policy in Germany Thorac Cardiovasc Surg 48 183–185 Occurrence Handle10.1055/s-2000-9637 Occurrence Handle1:STN:280:DC%2BD3M%2Fjt1Crtw%3D%3D Occurrence Handle10903067

    Article  CAS  PubMed  Google Scholar 

  11. GG Persijn B Cohen J de Meester (1995) ArticleTitleHigh-urgency repeat heart transplantation Transplant Proc 27 1282–1283 Occurrence Handle1:STN:280:ByqC1cvkvVE%3D Occurrence Handle7878882

    CAS  PubMed  Google Scholar 

  12. WB van den Hout JM Smits MC Deng M Hummel F Schoendube HH Scheld GG Persijn G Laufer (2003) ArticleTitleThe heart-allocation simulation model: a tool for comparison of transplantation allocation policies Transplantation 76 1492–1497 Occurrence Handle14657692

    PubMed  Google Scholar 

  13. J Groetzner I Kaczmarek B Meiser M Muller S Daebritz P Uberfuhr B Reichart (2002) ArticleTitleThe new German allocation system for donated thoracic organs causes longer ischemia and increased costs Thorac Cardiovasc Surg 50 376–379 Occurrence Handle10.1055/s-2002-35735 Occurrence Handle1:STN:280:DC%2BD38nps1GisA%3D%3D Occurrence Handle12457320

    Article  CAS  PubMed  Google Scholar 

  14. A Costard-Jackle SW Hirt B Fischer T Spahr U Foerst BM Zschiegner J Cremer (2003) ArticleTitleInfluence of organ allocation on outcome of transplant candidates Thorac Cardiovasc Surg 51 IssueIDSuppl 1 S64–S65

    Google Scholar 

  15. A El-Banayosy L Alsoglu L Kizner H Koertke M Morshuls R Koerfer (2004) ArticleTitleImpact of Eurotransplant High Urgency (HU) listing criteria on a bridge-to-transplant population Thorac Cardiovasc Surg 52 IssueIDSuppl 1 S17

    Google Scholar 

  16. InstitutionalAuthorNameJapan Organ Transplant Network (2003) ArticleTitleCurrent status of transplantation; Heart transplantation News Letter 7 4

    Google Scholar 

  17. The guidelines for selection of heart transplant recipients. Notification to the representative of Japan Organ Transplantation Network on guidelines for qualification of organ donors and selection of transplant recipients, issued by the Director-General of the Health Service Bureau, Ministry of Health and Welfare, Japan, on October 16th, 1997 (Reference number: HS1371)

  18. DG Renlund DO Taylor AG Kfoury RS Shaddy (1999) ArticleTitleNew UNOS rules: historical background and implications for transplantation management. United Network for Organ Sharing J Heart Lung Transplant 18 1065–1070 Occurrence Handle1:STN:280:DC%2BD3c%2FmsFOrug%3D%3D Occurrence Handle10598729

    CAS  PubMed  Google Scholar 

  19. N Fukushima Y Miyamoto S Ohtake Y Sawa T Takahashi M Nishimura (2004) ArticleTitleEarly result of heart transplantation in Japan: Osaka University experience Asian Cardiovasc Thorac Ann 12 154–158 Occurrence Handle15213084

    PubMed  Google Scholar 

  20. EA Rose AC Gelijns AJ Moskowitz DF Heitjan LW Stevenson W Dembitsky JW Long DD Ascheim AR Tierney RG Levitan JT Watson P Meier NS Ronan PA Shapiro RM Lazar LW Miller L Gupta OH Frazier P Desvigne-Nickens MC Oz VL Poirier (2001) ArticleTitleLong-term mechanical left-ventricular assistance for end-stage heart failure N Engl J Med 345 1435–1443 Occurrence Handle10.1056/NEJMoa012175 Occurrence Handle1:STN:280:DC%2BD38%2FmsFGnsQ%3D%3D Occurrence Handle11794191

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Takeshi Komoda MD.

Additional information

Part of this paper was presented at the 42nd JSAO Conference (Tokyo, October 5–7, 2004)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Komoda, T., Drews, T., Lehmkuhl, H. et al. Role of ventricular assist devices in the German heart allocation system. J Artif Organs 9, 29–33 (2006). https://doi.org/10.1007/s10047-005-0322-z

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10047-005-0322-z

Key words

Navigation