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Development of vitamin E-modified polysulfone membrane dialyzers

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Abstract

Oxygen radicals have recently been attracting close attention because of their involvement in tissue damage and their close relationship to various clinical conditions. It has been suggested that hemodialysis increases oxidative stress, triggering the development of complications such as atherosclerosis and dialysis-related amyloidosis. We recently developed a dialyzer containing a highly functional polysulfone membrane on which vitamin E had been bonded (PS-ViE). The present study was undertaken to evaluate the biocompatibility of this membrane and to conduct other experiments on the membrane in vitro. Human blood was dialyzed with minidialyzers (300–600 cm2 membrane area) made of PS-ViE, cellulose, or untreated polusulfone (PS), and the effects of the dialyzers on complements (C3a, C4a, and C5a), cytokines (IL-1β and IL-8), and granulocyte elastase as well as their anti-oxidative activity were investigated (n = 6). The effect of PS-ViE on complement activation and its effects on cytokines were comparable to those of PS membrane, whereas granulocyte elastase following dialysis with the PS-ViE membrane tended to be lower than that seen with PS membrane. The effects of PS-ViE-induced methemoglobin, lipid peroxide, and oxygen radicals were significantly less than those of PS membrane, indicating the antioxidative activity of PS-ViE. Vitamin E-modified polysulfone membrane dialyzers were found to have favorable effects on the immune system and to express antithrombotic and antioxidative effects.

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References

  1. M Sasaki (1990) Regenrated cellulose membrane BibInstitutionalEditorNameSociety for the Research of High-Performance Membrane (Eds) High-performance membrane for hemodialysis staff Igaku Tokyo 11–18

    Google Scholar 

  2. M Sasaki (1998) Regenrated cellulose membrane and vitamin E-modified cellulose membrane BibInstitutionalEditorNameSociety for the Research of New High-Performance Membrane (Eds) High-performance membrane for hemodialysis staff Igaku Tokyo 13–27

    Google Scholar 

  3. Sasaki M, Takahashi A, Ito H, Miyamoto T, Inagaki H. Developmemt of blood-compatible cellulose membranes for hemodialysis: cellulose structure and functional aspect. Ellis Horwood, Chichester, 1989;457–472

  4. M Hoshino M Sasaki N Hosoya S Tanaka H Suzuki S Kitamura M Hida (1997) ArticleTitleDevelopment of a new blood purification system with fluid purification, the “recycle filtration system.” Jpn J Artif Organs 26 IssueID1 147–152

    Google Scholar 

  5. H Suzuki M Hida M Sasaki S Kitamura (1997) ArticleTitleHemopurification using a recycle filtration system: first clinical results Jpn J Artif Organs 26 IssueID1 153–156

    Google Scholar 

  6. H Morta M Sasaki A Saito (1989) ArticleTitleStudies of enlargement of pore size in regenerated cellulose Jpn J Artif Organs 18 IssueID3 1137–1140

    Google Scholar 

  7. M Saruhashi N Hosoya M Sasaki (1992) ArticleTitlePhysical property evalution of regenerated-cellulose high-performance membrane Jpn J Artif Organs 24 IssueID3 1015–1020

    Google Scholar 

  8. H Morta T Tani M Sasaki (1992) ArticleTitleDevelopment of the antithrombogenecity of a dialyzer with a nonslice header Jpn J Artif Organs 21 IssueID3 1011–1014

    Google Scholar 

  9. H Hosoya T Tani S Takezawa M Sasaki (1996) ArticleTitleEvalution of a new dialyzer that can substitute much fluid – the plug dialyzer Jpn J Artif Organs 25 IssueID1 107–112

    Google Scholar 

  10. H Hosoya S Takezawa M Sasaki (1996) ArticleTitleEvalution of the plug dialyzer and post dilution HDF Ther Eng 10 IssueID1 59–61

    Google Scholar 

  11. Hosoya H, Takezawa S, Sasaki M. Development of the plug dialyzer. Kidney Dial (Suppl):1995:94–96

  12. M Satoh Y Yamasaki Y Nagake J Kasahara M Hashimoto N Nakanishi H Makino (2001) ArticleTitleOxidative stress is reduced by the long-term use of vitamin E-coated dialysis filters Kidney Int 59 1943–1950 Occurrence Handle10.1046/j.1523-1755.2001.0590051943.x Occurrence Handle1:CAS:528:DC%2BD3MXjs1ehtLs%3D Occurrence Handle11318967

    Article  CAS  PubMed  Google Scholar 

  13. T Sanaka (1991) ArticleTitleActive oxgen hypothesis Jpn J Artif Organs 24 IssueID3 283–287

    Google Scholar 

  14. D Tarhg T Huang T Liu H Chen Y Sung Y Wei (2000) ArticleTitleEffect of Vitamin E-bonded membrane on the 8-hydroxy 2′-deoxyguanosine level in leukocyte DNA of hemodialysis patients Kidney Int 58 790–799

    Google Scholar 

  15. D Bonnefont-Rousselot E Lehmann M Jaudon J Delattre B Perrone J Rechke (2000) ArticleTitleBlood oxidative stress and lipoprotein oxidizability in haemodialysis patients: effect of the use of a vitamin E-coated dialysis membrane Nephrol Dial Transplant 15 2020–2028 Occurrence Handle1:CAS:528:DC%2BD3cXptVeitLw%3D Occurrence Handle11096149

    CAS  PubMed  Google Scholar 

  16. D Tanimu S Huraib F Hejaili C Giles Y Pagayon (2000) ArticleTitleThe Effect of Vitamin E-modified dialysers on acute intra-dialytic symptoms: a comparative crossover study Saudi J Kidney Dis Transplant 11 IssueID4 559–562

    Google Scholar 

  17. T Shimazu M Ominato K Toyama T Yasuda T Sato T Maeda S Owada M Ishida (1999) ArticleTitleEffect of vitamin E-modified regenerative cellulose membrane on neutrophil superoxide anion radical production and lipid peroxidation. Vitamin E-bonded membrane – a further step in dialysis optimization Contrib Nephrol 127 251–260 Occurrence Handle1:CAS:528:DC%2BD3cXisVals7c%3D Occurrence Handle10629794

    CAS  PubMed  Google Scholar 

  18. F Galli S Rovidati L Chirantini G Campus F Canestrari U Buoncristiani (1998) ArticleTitleBioreactivity and biocompatibility of a vitamin E-modified multilayer hemodialysis filter Kidney Int 54 580–589 Occurrence Handle10.1046/j.1523-1755.1998.00021.x Occurrence Handle1:STN:280:DyaK1czlsVKrsQ%3D%3D Occurrence Handle9690226

    Article  CAS  PubMed  Google Scholar 

  19. Burton GW, Ingold KU, Thompson KE. An improved procedure for isolation of ghost membrane from human red blood cells. Lipid 1981;16–946

  20. M Sasaki M Saruhashi N Hosoya (2000) ArticleTitleVitamin E-modified cellulose membrane Artif Organs 24 IssueID10 779–789 Occurrence Handle10.1046/j.1525-1594.2000.06489.x Occurrence Handle1:CAS:528:DC%2BD3cXosFKntrc%3D Occurrence Handle11091167

    Article  CAS  PubMed  Google Scholar 

  21. M Saruhashi H Morta M Sasaki (1992) ArticleTitleBiocompatibility of the newly developed modified regenerated cellulose membrane Jpn J Artif Organs 21 IssueID3 1025–1030

    Google Scholar 

  22. M Sasaki M Saruhashi N Hosoya (1999) ArticleTitleDevelopmemt of vitamin E-modified cellulose membrane Contrib Nephrol 127 49–70 Occurrence Handle1:CAS:528:DC%2BD3cXisValsrs%3D Occurrence Handle10629776

    CAS  PubMed  Google Scholar 

  23. Emoto H, Sasaki M. An in vitro study of lipid adosorption on vitamin E-modified dialysis during hemodailysis. Vitamembrane 2001;16–18

  24. M Sasaki N Hosoya M Saruhashi N Hosoya (1994) ArticleTitleVitamin E-modified cellulose membrane Membrane 19 IssueID6 400–410 Occurrence Handle1:CAS:528:DyaK2MXjtVeitLg%3D

    CAS  Google Scholar 

  25. M Sasaki (1995) ArticleTitleVitamin E-modified cellulose membrane Membrane 20 IssueID3 239–241 Occurrence Handle1:CAS:528:DyaK2MXmtFKmt7w%3D

    CAS  Google Scholar 

  26. M Saruhashi H Watanabe M Sasaki (1995) ArticleTitleBiocompatibility of vitamin E-modified regenerated cellulose Jpn J Artif Organs 24 IssueID3 631–636

    Google Scholar 

  27. M Saruhashi M Sasaki (2000) ArticleTitleAntioxidant function of vitamin E-modified dailyzer CL-EE Jpn J Artif Organs 29 IssueID1 161–165

    Google Scholar 

  28. Sasaki M, Saruhashi M. Antioxidant function of vitamin E-modified dialysis CL-EE. Vitamembrane 2001;22–29

  29. T Takagi T Momoi S Sugiura S Hisanaga M Ono H Ogawa A Saito (1994) ArticleTitleBiocompatibility of modified regenerated cellose membrane (CL-E) Kidney Dial High Perform Mem 36 128–131

    Google Scholar 

  30. M Ono T Takagi A Saito (1994) ArticleTitleClinical evaluation of dialyzer CL-12E Jpn J Clin Dial 10 IssueID10 1585–91

    Google Scholar 

  31. T Shimazu M Ominato K Toyama T Yasuda T Sato T Maeba S Oowada M Ishida (2001) ArticleTitleEffects of a vitamin E-modified dialysis membrane on neutrophil superoxide anion radical production Kidney Int 59 IssueIDSuppl 78 137–143

    Google Scholar 

  32. M Mydilik K Derziova O Racz A Sipulova E Lovason (2001) ArticleTitlePeterovicova. A modified dialyzer with vitamin E and antioxidant defense parameters Kidney Int 59 IssueIDSuppl 78 144–147

    Google Scholar 

  33. F Galli Z Varga J Balla B Ferraro F Canestrari A Floridio G Kakuk U Buoncristiani (2001) ArticleTitleVitamin E, lipid profile, and peroxidation in hemodialysis patients Kidney Int 59 IssueIDSuppl 78 148–154

    Google Scholar 

  34. S Huraib D Tanimu F Shaheen F Hejaili C Giles V Pagayon (2000) ArticleTitleEffect of vitamin E-modified dialysers on dialyser clotting, erythropoietin and heparin dosage: a comparative crossover study Am J Nephrol 20 364–368 Occurrence Handle10.1159/000013617 Occurrence Handle1:STN:280:DC%2BD3M%2FmtlCmsw%3D%3D Occurrence Handle11092992

    Article  CAS  PubMed  Google Scholar 

  35. M Omata H Higuchi R Demura T Sanaka N Nihei (2000) ArticleTitleReduction of neutrophil activation by vitamin E-modified dialyzer membranes Nephron 85 221–231 Occurrence Handle10.1159/000045665 Occurrence Handle1:CAS:528:DC%2BD3cXlsFGktrg%3D Occurrence Handle10867537

    Article  CAS  PubMed  Google Scholar 

  36. M Inal G Kanbak E Sunal (1999) ArticleTitleDose Vitamin E Bound on Dialysis membrane Improve the LDL Susceptibility to Oxidation? Lessons from an in vitro Model Contrib Nephrol 127 128–138

    Google Scholar 

  37. M Taccone-Gallucci C Meloni R Lubrano M Morosetti G Palombo P Cianulli P Scoppi M Castello C Casciani (1999) ArticleTitleChronic haemolysis and erythrocyte survival in haemodialysis patients treated with vitamin E-modified dialysis filters. Vitamin E-bonded membrane – a further step in dialysis optimization Contrib Nephrol 127 44–48 Occurrence Handle1:STN:280:DC%2BD3c%2FpsFaguw%3D%3D Occurrence Handle10629775

    CAS  PubMed  Google Scholar 

  38. P Calzavara S Angeil C Gatto M Dugo R Puggia G Calconi (1999) ArticleTitleMorphologic evaluation of red blood cells using vitamin E-modified dialysis filters. Vitamin E-bonded membrane – a further step in dialysis optimization Contrib Nephrol 127 172–176 Occurrence Handle1:STN:280:DC%2BD3c%2FpsFamsg%3D%3D Occurrence Handle10629786

    CAS  PubMed  Google Scholar 

  39. M Usberti G Bufano G Lima M Gazzotti P Tira G Geradi D Lorenzo (1999) ArticleTitleIncreased red blood cell survival reduces the need of erythropoietin in hemodialyzed patients treated with exogenous glutathione and vitamin E-modified membrane. Vitamin E-bonded membrane – a further step in dialysis optimization Contrib Nephrol 127 208–214 Occurrence Handle1:CAS:528:DC%2BD3cXisVals7s%3D Occurrence Handle10629790

    CAS  PubMed  Google Scholar 

  40. P Odetti C Robaudo S Valentini G Gurreri S Garibaldi S Angeletti G Deferrari (1999) ArticleTitleEffect of a new vitamin E-coated membrane on glycoxidation during hemodialysis. Vitamin E-bonded membrane – a further step in dialysis optimization contrib nephrol 127 192–199 Occurrence Handle1:CAS:528:DC%2BD3cXisVals70%3D Occurrence Handle10629788

    CAS  PubMed  Google Scholar 

  41. M Morena J Cristol B Descomps B Canaud (1999) ArticleTitleDoes vitamin E bound on dialysis membrane improve the LDL susceptibility to oxidation? Lessons from an in vitro model. Vitamin E-bonded membrane – a further step in dialysis optimization Contrib Nephrol 127 251–260

    Google Scholar 

  42. M Mine S Yukawa M Kishino H Otani K Kimura O Nshikawa T Takahashi N Kodama Y Saika Y Yamada (1999) ArticleTitleEffect of vitamin E on lipid metabolism and atherosclerosis in ESRD patients Kidney Int 56 IssueIDSuppl 71 S-126–129

    Google Scholar 

  43. F Galli S Rovidati L Chirantini G Campus F Canestrari U Buoncristiani (1998) ArticleTitleBioreactivity and biocompatibility of a vitamin E-modified multilayer hemodialysis filter Kidney Int 54 580–589 Occurrence Handle10.1046/j.1523-1755.1998.00021.x Occurrence Handle1:STN:280:DyaK1czlsVKrsQ%3D%3D Occurrence Handle9690226

    Article  CAS  PubMed  Google Scholar 

  44. VH Cohn (1970) Fat-soluble vitamins LS Goodman (Eds) The pharmacological basis of therapeutics EditionNumber4th edn. Collier-Macmillan London 1690–1699

    Google Scholar 

  45. JK Lloyd DP Muller (1972) Management of abetalipoproteinaemia in childhood H Peeters (Eds) Protides of the biological fluid Pergamon Oxford 331–335

    Google Scholar 

  46. M Mino E Vitamin (1980) Vitamin E BibInstitutionalEditorNameJapanese Society for Vitamins (Eds) Vitaminology: oil-soluble vitamins Kagagu Dojin Tokyo 177–183

    Google Scholar 

  47. W Henderson KM Koch CA Dinarello S Shaldon (1983) ArticleTitleHemodialysis hypotention: the interleukin hypothesis Blood Purif 1 3–8 Occurrence Handle1:CAS:528:DyaL2cXitFWnuw%3D%3D

    CAS  Google Scholar 

  48. M Ono T Takagi T Momoi H Kotani M Sato K Sugiura H Ogawa A Saito M Toyama (1991) ArticleTitleProduction of IL-1 at peripheral blood mononuclear cell culture in a hemodialysis patient Kidney Dial High Perform Mem 30 8–12

    Google Scholar 

  49. S Tsuruoka A Kawaguchi A Fujimura (2002) ArticleTitleVitamin E-bonded hemodialyzer improves neutrophil function and oxidative stress in patients with end-stage renal failure Am J Kidney Dis 39 IssueID1 127–133 Occurrence Handle11774111

    PubMed  Google Scholar 

  50. A Yoshida (1986) ArticleTitleGranyulocyte elastase as a new marker for evaluation of biocompatibility Jpn J Artif Organs 15 IssueID5 1849–1856

    Google Scholar 

  51. H Kato (1979) The Hageman factor N Aoki S Iwanaga (Eds) Blood coagulation, fibrinolysis, and kinin Chugai Igaku Tokyo 113–121

    Google Scholar 

  52. E Noiri S Yamada A Nakao M Tuchiya I Masaki K Fujino K Nosaka T Osawa T Fujita K Uchida et al. (2002) ArticleTitleSerum protein acrolein adducts: utility in detecting oxidant stress in hemodialysis patients and reversal using vitamin E-bonded hemodialyzer Free Radic Biol Med 33 IssueID12 1651–1656 Occurrence Handle10.1016/S0891-5849(02)01138-3 Occurrence Handle1:CAS:528:DC%2BD38XpsFWhs7g%3D Occurrence Handle12488133

    Article  CAS  PubMed  Google Scholar 

  53. F Takahashi (Eds) (1987) Blood Igakusyoin Tokyo

    Google Scholar 

  54. S Kobayashi H Moriya K Aso T Ohtaka (2003) ArticleTitleVitamin E-bonded hemodialyzer improves athrosclerosis associated with a rheolgical improvement of circulating red blood cells Kidney Int 63 1881–1887 Occurrence Handle10.1046/j.1523-1755.2003.00920.x Occurrence Handle1:CAS:528:DC%2BD3sXjslygsbo%3D Occurrence Handle12675867

    Article  CAS  PubMed  Google Scholar 

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  1. Development and Scientific Affairs Division, Asahi Kasei Medical Co., Ltd., MD Kanda Bldg., 9-1 Kanda Mitoshiro-cho, Chiyoda-ku, Tokyo, 101-8482, Japan

    Masatomi Sasaki MS

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Sasaki, M. Development of vitamin E-modified polysulfone membrane dialyzers. J Artif Organs 9, 50–60 (2006). https://doi.org/10.1007/s10047-005-0318-8

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