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A new scheme of the time-domain fluorescence tomography for a semi-infinite turbid medium

  • Special Section: Regular Paper
  • Biomedical Imaging and Sensing Conference (BISC2016), Yokohama, Japan
  • Published:
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Abstract

A new scheme for reconstruction of a fluorophore target embedded in a semi-infinite medium was proposed and evaluated. In this scheme, we neglected the presence of the fluorophore target for the excitation light and used an analytical solution of the time-dependent radiative transfer equation (RTE) for the excitation light in a homogeneous semi-infinite media instead of solving the RTE numerically in the forward calculation. The inverse problem for imaging the fluorophore target was solved using the Landweber–Kaczmarz method with the concept of the adjoint fields. Numerical experiments show that the proposed scheme provides acceptable results of the reconstructed shape and location of the target. The computation times of the solution of the forward problem and the whole reconstruction process were reduced by about 40 and 15%, respectively.

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Acknowledgements

This work was supported by the Japan Agency for Medical Research and Development (AMED).

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Authors and Affiliations

  1. Research Institute for Electronic Science, Hokkaido University, N20W10, Sapporo, 001-0020, Japan

    Kernel Prieto & Goro Nishimura

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  1. Kernel Prieto
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  2. Goro Nishimura
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Correspondence to Goro Nishimura.

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Prieto, K., Nishimura, G. A new scheme of the time-domain fluorescence tomography for a semi-infinite turbid medium. Opt Rev 24, 242–251 (2017). https://doi.org/10.1007/s10043-017-0309-z

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  • DOI: https://doi.org/10.1007/s10043-017-0309-z

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