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Optically deviated focusing method based high-speed SD-OCT for in vivo retinal clinical applications

  • Special Section: Regular Paper
  • The 5th Asian and Pacific-Rim Symposium on Biophotonics, (APBP’15), Yokohama, Japan
  • Published:
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Abstract

The aim of this study is to provide accurately focused, high-resolution in vivo human retinal depth images using an optically deviated focusing method with spectral-domain optical coherence tomography (SD-OCT) system. The proposed method was applied to increase the retinal diagnosing speed of patients with various values of retinal distances (i.e., the distance between the crystalline eye lens and the retina). The increased diagnosing speed was facilitated through an optical modification in the OCT sample arm configuration. Moreover, the optical path length matching process was compensated using the proposed optically deviated focusing method. The developed system was mounted on a bench-top cradle to overcome the motion artifacts. Further, we demonstrated the capability of the system by carrying out in vivo retinal imaging experiments. The clinical trials confirmed that the system was effective in diagnosing normal and abnormal retinal layers as several retinal abnormalities were identified using non-averaged single-shot OCT images, which demonstrate the feasibility of the method for clinical applications.

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Acknowledgments

The authors are grateful to the Industrial Strategic Technology Development Program, Grant No. 10047943; the “Development of Micro-surgical Apparatus based on 3D Tomographic Operating Microscope” program, funded by the Ministry of Trade, Industry & Energy (MI, Korea, No. 10047943). This study was also supported by the BK21 Plus project funded by the Ministry of Education, Korea (21A20131600011).

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Authors and Affiliations

  1. School of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, 702-701, Korea

    Ruchire Eranga Wijesinghe, Kibeom Park, Kwangtae Kim, Mansik Jeon & Jeehyun Kim

  2. OZ Tech, No 901, IT Convergence Industrial Building, 47, Gyeongdae-ro, 17-gil, Buk-gu, Daegu, Korea

    Pilun Kim & Jeehyun Kim

  3. Department of Biomedical Engineering, College of Health Science, Korea University, Seongbuk-gu, Seoul, 136-703, Korea

    Beop-Min Kim

  4. Department of Ophthalmology, Korea University Anam Hospital, 73, Inchon-ro, Seongbuk-gu, Seoul, 136-705, Korea

    Jaeryung Oh

  5. Department of Ophthalmology, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 425-707, Korea

    Seong-Woo Kim

Authors
  1. Ruchire Eranga Wijesinghe
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  2. Kibeom Park
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  3. Pilun Kim
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  4. Jaeryung Oh
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  5. Seong-Woo Kim
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  6. Kwangtae Kim
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  7. Beop-Min Kim
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  8. Mansik Jeon
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  9. Jeehyun Kim
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Correspondence to Mansik Jeon.

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Wijesinghe, R.E., Park, K., Kim, P. et al. Optically deviated focusing method based high-speed SD-OCT for in vivo retinal clinical applications. Opt Rev 23, 307–315 (2016). https://doi.org/10.1007/s10043-015-0154-x

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  • DOI: https://doi.org/10.1007/s10043-015-0154-x

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