Journal of Human Genetics

, Volume 49, Issue 5, pp 227–231 | Cite as

Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia

  • Kazuya Iwamoto
  • Miki Bundo
  • Shinsuke Washizuka
  • Chihiro Kakiuchi
  • Tadafumi Kato
Original Article


We have previously reported the altered expressions of HSPF1 and LIM in the lymphoblastoid cell lines (LCLs) derived from Japanese patients with bipolar disorder (bipolar I disorder). The altered expression at the LCL level would be useful for developing diagnostic markers as well as a cellular model for bipolar disorder. In this study, we extended our previous study by measuring their expressions using the following samples: (1) larger number of LCLs from Japanese subjects, (2) LCLs from Caucasian subjects, and (3) LCLs from patients with bipolar II disorder or schizophrenia. We confirmed the increased expression of HSPF1 (P=0.009) and decreased expression of LIM (P=0.001) in the LCLs from patients with Japanese bipolar I disorder. These altered expressions were also observed in those from patients with Japanese bipolar II disorder (P=0.002 for HSPF1 and P=0.072 for LIM). We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P=0.001).


Lymphoblastoid cells Heat shock protein (HSP) LIM Mental disorder 



The authors thank the individuals with bipolar disorder and unaffected volunteers who participated in this study. The authors thank Mizuho Ishiwata and Mizue Kametani for their technical assistance. Data and biomaterials of the NIMH pedigrees were collected in four projects that participated in the NIMH Bipolar Disorder Genetics Initiative. From 1991 to 1998, the principal investigators and coinvestigators were: Indiana University, Indianapolis, IN, USA, U01MH46282, J. Nurnberger, M. Miller, and E. Bowman; Washington University, St Louis, MO, USA, U01 MH46280, T. Reich, A. Goate, and J. Rice; Johns Hopkins University, Baltimore, MD, USA, U01 MH46274, J. R. DePaulo Jr, S. Simpson, and C. Stine; NIMH Intramural Research Program, Clinical Neurogenetics Branch, Bethesda, MD, USA, E. Gershon, D. Kazuba, and E. Maxwell.


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Copyright information

© The Japan Society of Human Genetics and Springer-Verlag 2004

Authors and Affiliations

  • Kazuya Iwamoto
    • 1
  • Miki Bundo
    • 1
  • Shinsuke Washizuka
    • 2
  • Chihiro Kakiuchi
    • 1
  • Tadafumi Kato
    • 1
  1. 1.Laboratory for Molecular Dynamics of Mental Disorders, Brain Science InstituteRIKENWakoJapan
  2. 2.Department of Psychiatry, Faculty of MedicineShinshu UniversityMatsumotoJapan

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