Abstract
Purpose
One-third of patients presenting with inguinal hernia are asymptomatic and the best treatment for these patients is unclear. The aim of this study was to assess the feasibility of applying a watchful waiting strategy for asymptomatic or minimally symptomatic inguinal hernia in men.
Methods
PubMed, EMBASE, and Cochrane Library were searched from database inception to May 14, 2020. Included were all types of original data written in English, German, Danish, Swedish, or Norwegian involving ≥ 5 male patients aged ≥ 18 years old with asymptomatic or minimally symptomatic inguinal hernia and undergoing watchful waiting. This review was reported according to the PRISMA guideline.
Results
A total of nine studies were included; three randomized controlled trials, three prospective cohort studies, and three retrospective cohort studies. Data on a total of 858 unique patients following a watchful waiting strategy were included. Approximately one-third of patients crossed over from watchful waiting to surgery after 3 years increasing to more than two-thirds after 10 years. The most frequent reason for crossover was hernia-related pain (median 79%, range 48–91%). The rate of acute hernia-related operations was low (2–3%), and watchful waiting was not associated with increased mortality or postoperative complications. Levels of pain and discomfort after randomization were similar over time between patients undergoing elective repair or watchful waiting.
Conclusion
Applying a watchful waiting strategy to men with asymptomatic or minimally symptomatic inguinal hernia was safe, but two-thirds of patients crossed over to surgical repair within 10 years mainly due to pain.
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References
Primatesta P, Goldacre MJ (1996) Inguinal hernia repair: incidence of elective and emergency surgery, readmission and mortality. Int J Epidemiol 25:835–839. https://doi.org/10.1093/ije/25.4.835
Bay-Nielsen M, Kehlet H, Strand L, Malmstrøm J, Andersen FH, Wara P et al (2001) Quality assessment of 26,304 herniorrhaphies in Denmark: a prospective nationwide study. Lancet 358:1124–1128. https://doi.org/10.1016/S0140-6736(01)06251-1
HerniaSurge Group (2018) International guidelines for groin hernia management. Hernia 22:1–165. https://doi.org/10.1007/s10029-017-1668-x
Poobalan AS, Bruce J, Smith WC, King PM, Krukowski ZH, Chambers WA (2003) A review of chronic pain after inguinal herniorrhaphy. Clin J Pain 19:48–54. https://doi.org/10.1097/00002508-200301000-00006
Lundström KJ, Holmberg H, Montgomery A, Nordin P (2018) Patient-reported rates of chronic pain and recurrence after groin hernia repair. Br J Surg 105:106–112. https://doi.org/10.1002/bjs.10652
Grant AM, Scott NW, O’Dwyer PJ, MRC Laparoscopic Groin Hernia Trial Group (2004) Five-year follow-up of a randomized trial to assess pain and numbness after laparoscopic or open repair of groin hernia. Br J Surg 91:1570–1574. https://doi.org/10.1002/bjs.4799
Aasvang E, Kehlet H (2005) Chronic postoperative pain: the case of inguinal herniorrhaphy. Br J Anaesth 95:69–76. https://doi.org/10.1093/bja/aei019
Bay-Nielsen M, Perkins FM, Kehlet H, Database DH (2001) Pain and functional impairment 1 year after inguinal herniorrhaphy: a nationwide questionnaire study. Ann Surg 233:1–7. https://doi.org/10.1097/00000658-200101000-00001
Fränneby U, Sandblom G, Nordin P, Nyrén O, Gunnarsson U (2006) Risk factors for long-term pain after hernia surgery. Ann Surg 244:212–219. https://doi.org/10.1097/01.sla.0000218081.53940.01
Bay-Nielsen M, Nilsson E, Nordin P, Kehlet H, Base SHD, Base DHD (2004) Chronic pain after open mesh and sutured repair of indirect inguinal hernia in young males. Br J Surg 91:1372–1376. https://doi.org/10.1002/bjs.4502
Hair A, Paterson C, Wright D, Baxter JN, O’Dwyer PJ (2001) What effect does the duration of an inguinal hernia have on patient symptoms? J Am Coll Surg 193:125–129. https://doi.org/10.1016/S1072-7515(01)00983-8
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336–341. https://doi.org/10.1016/j.ijsu.2010.02.007
PROSPERO (2020) Watchful waiting vs repair for asymptomatic or minimally symptomatic inguinal hernia in men: a systematic review. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=86571. Accessed 11 Jun 2020
Covidence systematic review software (2020) Veritas Health Innovation, Melbourne, Australia. https://www.covidence.org. Accessed 11 Jun 2020
Cochrane Collaboration. Higgins JPT, Altman DG, Sterne JAC (eds) (2020) Assessing risk of bias in included studies. https://handbook-5-1.cochrane.org/chapter_8/8_assessing_risk_of_bias_in_included_studies.htm. Accessed 11 Jun 2020
Cochrane Collaboration. Reeves BC, Deeks JJ, Higgins JPT, Wells GA (eds) (2020) Including non-randomized studies. https://handbook-5-1.cochrane.org/chapter_13/13_including_non_randomized_studies.htm. Accessed 11 Jun 2020
Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al (2020) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. The Ottawa Hospital. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 11 Jun 2020
Fitzgibbons RJ, Giobbie-Hurder A, Gibbs JO, Dunlop DD, Reda DJ, McCarthy M et al (2006) Watchful waiting vs repair of inguinal hernia in minimally symptomatic men: a randomized clinical trial. JAMA 295:285–292. https://doi.org/10.1001/jama.295.3.285
Thompson JS, Gibbs JO, Reda DJ, McCarthy M, Wei Y, Giobbie-Hurder A et al (2008) Does delaying repair of an asymptomatic hernia have a penalty? Am J Surg 195:89–93. https://doi.org/10.1016/j.amjsurg.2007.07.021
Sarosi GA, Wei Y, Gibbs JO, Reda DJ, McCarthy M, Fitzgibbons RJ et al (2011) A clinicianʼs guide to patient selection for watchful waiting management of inguinal hernia. Ann Surg 253:605–610. https://doi.org/10.1097/sla.0b013e31820b04e9
Fitzgibbons RJ, Ramanan B, Arya S, Turner SA, Li X, Gibbs JO et al, Investigators of the Original Trial (2013) Long-term results of a randomized controlled trial of a nonoperative strategy (watchful waiting) for men with minimally symptomatic inguinal hernias. Ann Surg 258:508–515. https://doi.org/10.1097/sla.0b013e3182a19725
O’Dwyer PJ, Norrie J, Alani A, Walker A, Duffy F, Horgan P (2006) Observation or operation for patients with an asymptomatic inguinal hernia: a randomized clinical trial. Ann Surg 244:167–173. https://doi.org/10.1097/01.sla.0000217637.69699.ef
Chung L, Norrie J, O’Dwyer PJ (2011) Long-term follow-up of patients with a painless inguinal hernia from a randomized clinical trial. Br J Surg 98:596–599. https://doi.org/10.1002/bjs.7355
de Goede B, Wijsmuller AR, van Ramshorst GH, van Kempen BJ, Hop WCJ, Klitsie PJ et al (2018) Watchful waiting versus surgery of mildly symptomatic or asymptomatic inguinal hernia in men aged 50 years and older: a randomized controlled trial. Ann Surg 267:42–49. https://doi.org/10.1097/sla.0000000000002243
Aktimur R, Çetinkünar S, Yildirim K, Özdaş S, Aktimur SH, Çolak E et al (2014) Comparison of the outcomes of watchful waiting and surgery in 80 years of age and older comorbid and minimally symptomatic inguinal hernia patients. Turk Geriatri Derg 17:338–344
Patti R, Aiello P, Caruso AM, Cudia B, Di Vita G (2014) The improvement of quality of life a indication for elective surgery in elderly patients with minimally symptomatic inguinal hernia. Ann Ital Chir 85:136–142
Andresen K, Burcharth J, Fonnes S, Hupfeld L, Rothman JP, Deigaard S et al (2017) Chronic pain after inguinal hernia repair with the ONSTEP versus the Lichtenstein technique, results of a double- blinded multicenter randomized clinical trial. Langenbecks Arch Surg 402:213–218. https://doi.org/10.1007/s00423-016-1532-y
Langeveld HR, Klitsie P, Smedinga H, Eker H, Van’t Riet M, Weidema W et al (2015) Prognostic value of age for chronic postoperative inguinal pain. Hernia 19:549–555. https://doi.org/10.1007/s10029-014-1282-0
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This study received no financial support from extramural sources.
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All authors contributed to the idea and design of the study. HR performed the literature search. SF and HR conducted eligibility screening. HR drafted the manuscript. SF and JR critically revised the work. All authors read and approved the final manuscript and agreed to be accountable for the content of this manuscript.
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Reistrup, H., Fonnes, S. & Rosenberg, J. Watchful waiting vs repair for asymptomatic or minimally symptomatic inguinal hernia in men: a systematic review. Hernia 25, 1121–1128 (2021). https://doi.org/10.1007/s10029-020-02295-3
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DOI: https://doi.org/10.1007/s10029-020-02295-3