Collagen in colon disease

Abstract

The pathophysiology of wound healing in the bowel wall suggests that collagen and matrix metalloproteinases (MMPs) have an important role in the changes of the bowel wall seen in several colonic diseases. Several recent studies suggest that disturbances of the collagen texture and the extracellular matrix (ECM) metabolism are major factors leading to the onset of diverticular disease. Changes of the ECM also play a role in the development of inflammatory bowel diseases. Regarding the permanent remodeling of the bowel wall, any imbalance of the ECM could support the onset of chronic inflammation and the development of fistula formation, such as that seen in patients with Crohn’s disease. Disturbances of the ECM play a role in the pathogenesis of anastomotic leakage after large bowel surgery and suggest the presence of a genetically defined risk population with disturbed wound healing mechanisms. This concept could explain the well known situation where an anastomotic breakdown is observed, despite the absence of other known risk factors and after a technically correct anastomosis.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Fleischmajer R, Perlish JS, Burgeson RE, Shaikh-Bahai F, Timpl R (1990) Type I and type III collagen interactions during fibrillogenesis. Ann N Y Acad Sci 580(1):161–175

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Sommerville RP, Oblander SA, Apte SS (2003) Matrix metalloproteinases: old dogs with new tricks. Genome Biol 4(6):216–222

    Article  Google Scholar 

  3. 3.

    Painter NS, Truelove SC, Ardran GM, Tuckey M (1965) Segmentation and the localization of intraluminal pressures in the human colon, with special reference to the pathogenesis of colonic diverticula. Gastroenterology 49:169–177

    PubMed  CAS  Google Scholar 

  4. 4.

    Schoetz DJ Jr (1999) Diverticular disease of the colon: a century-old problem. Dis Colon Rectum 42(6):703–709

    PubMed  Article  Google Scholar 

  5. 5.

    Whiteway J, Morson BC (1985) Elastosis in diverticular disease of the sigmoid colon. Gut 26(3):258–266

    PubMed  CAS  Google Scholar 

  6. 6.

    Watters DAK, Smith AN, Eastwood MA, Anderson KC, Elton RA, Mugerwa JW (1985) Mechanical properties of the colon: comparison of the features of the African and European colon in vitro. Gut 26(4):384–392

    PubMed  CAS  Google Scholar 

  7. 7.

    Wess L, Eastwood MA, Wess TJ, Busuttil A, Miller A (1995) Cross linking of collagen is increased in colonic diverticulosis. Gut 37(1):91–94

    PubMed  CAS  Google Scholar 

  8. 8.

    Hoffmann P, Layer P (1995) Pathogenesis and pathophysiology of sigmoid diverticulitis (in German). Chirurg 66(12):1169–1172

    PubMed  CAS  Google Scholar 

  9. 9.

    Stumpf M, Cao W, Klinge U, Klosterhalfen B, Kasperk R, Schumpelick V (2001) Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease. Int J Colorectal Dis 16(5):271–275

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Parra-Blanco A (2006) Colonic diverticular disease: pathophysiology and clinical picture. Digestion 73(Suppl 1):47–57

    PubMed  Article  Google Scholar 

  11. 11.

    Okabe N (2001) The pathogenesis of Crohn’s disease. Digestion 63(Suppl 1):52–59

    PubMed  Article  Google Scholar 

  12. 12.

    Brignola C, Belloli C, Ardizzone S, Astegiano M, Cottone M, Trallori G (2000) The relationship between heritability and smoking habits in Crohn’s disease. Italian Cooperative Study Group. Am J Gastroenterol 95(11):3171–3175

    PubMed  Article  CAS  Google Scholar 

  13. 13.

    Jorgensen LN, Kallehave F, Christensen E, Siana JE, Gottrup F (1998) Less collagen production in smokers. Br J Surg 123(4):450–455

    CAS  Google Scholar 

  14. 14.

    Alexander AC, Irving MH (1990) Accumulation and pepsin solubility of collagens in the bowel of patients with Crohn’s disease. Dis Colon Rectum 33(11):956–962

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Stallmach A, Schuppan D, Riese HH, Metthes H, Riecken EO (1992) Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn’s disease. Gastroenterology 102(6):1920–1929

    PubMed  CAS  Google Scholar 

  16. 16.

    Stumpf M, Cao W, Klinge U, Klosterhalfen B, Junge K, Krones CJ, Schumpelick V (2005) Reduced expression of collagen type I and increased expression of matrix metalloproteinases 1 in patients with Crohn’s Disease. J Invest Surg 18(1):33–38

    PubMed  Article  Google Scholar 

  17. 17.

    Kjeldsen J, Schaffalitzky de Muckadell OB, Junker P (1995) Seromarkers of collagen I and III metabolism in active Crohn’s disease. Relation to disease activity and response to therapy. Gut 37(6):805–810

    PubMed  CAS  Google Scholar 

  18. 18.

    Louis E, Ribbens C, Godon A, Franchimont D, De Groote D, Hardy N, Boniver J, Belaiche J, Malaise M (2000) Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. Clin Exp Immunol 120(2):241–246

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    von Lampe B, Barthel B, Coupland SE, Riecken EO, Rosewicz S (2000) Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 47(1):63–73

    Article  Google Scholar 

  20. 20.

    McKaig BC, McWilliams D, Watson SA, Mahida YR (2003) Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am J Pathol 162(4):1355–1360

    PubMed  CAS  Google Scholar 

  21. 21.

    Matthiessen P, Hallbook O, Rutegard J, Sjjodahl R (2006) Population-based study of risk factors for postoperative death after anterior resection of the rectum. Br J Surg 93(4):498–503

    PubMed  Article  CAS  Google Scholar 

  22. 22.

    Alves A, Panis Y, Trancart D, Regimbeau JM, Pocard M, Valleur P (2002) Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients. World J Surg 26(4):499–502

    PubMed  Article  Google Scholar 

  23. 23.

    Stumpf M, Klinge U, Wilms A, Zabrocki R, Rosch R, Junge K, Krones CJ, Schumpelick V (2005) Changes of the extracellular matrix as a risk factor for anastomotic leakage after large bowel surgery. Surgery 137(2):229–234

    PubMed  Article  Google Scholar 

  24. 24.

    Baker EA, Leaper DJ (2003) The plasminogen activator and matrix metalloproteinase system in colorectal cancer: relationship to tumor pathology. Eur J Cancer 39:981–988

    PubMed  Article  CAS  Google Scholar 

  25. 25.

    Di Cholandrea T, Wang L, Wille J, D’Armiento J, Chada KK (1998) Epidermal expression of collagenase delays wound-healing in transgenic mice. J Invest Dermatol 111(6):1029–1033

    Article  Google Scholar 

  26. 26.

    Stumpf M, Cao W, Klinge U, Klosterhalfen B, Kasperk R, Schumpelick V (2002) Collagen distribution and expression of matrix metalloproteinases 1 and 13 in patients with anastomotic leakage after large-bowel surgery. Langenbecks Arch Surg 386(7):502–506

    PubMed  Article  Google Scholar 

  27. 27.

    Stumpf M, Klinge U, Mertens PR (2004) Anastomotic leakage in the gastrointestinal tract-repair and prognosis (in German). Chirurg 75(11):1056–1062

    PubMed  Article  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Michael Stumpf.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Stumpf, M., Krones, C.J., Klinge, U. et al. Collagen in colon disease. Hernia 10, 498–501 (2006). https://doi.org/10.1007/s10029-006-0149-4

Download citation

Keywords

  • Extracellular matrix
  • Bowel disease
  • MMPs
  • Anastomotic leakage
  • Diverticular diseases
  • Crohn’s disease