Abstract
Collagens belong to the most abundant proteins in the body. After tissue injury, a coordinated regulation of collagen gene expression guides the formation of a provisional matrix that subsequently evolves into a mature scar with tensile strength. In the following, knowledge regarding collagen gene regulation that may provide insight into how to specifically address the biological problem of soft tissue weakness and recurrent hernia disease is summarized.
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Acknowledgments
This work was supported by the Deutsche Forschungsgemeinschaft, DFG grant KL 1320/2-1 (U.K., P.R.M.) and JA 1123/1-1 (P.L.J., U.K., P.R.M., M.J.).
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Lynen Jansen, P., Klinge, U. & Mertens, P.R. Hernia disease and collagen gene regulation: are there clues for intervention?. Hernia 10, 486–491 (2006). https://doi.org/10.1007/s10029-006-0147-6
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DOI: https://doi.org/10.1007/s10029-006-0147-6