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Takayasu's Arteritis Coexisting with Wegener's Granulomatosis in a Teenager with Renal Insufficiency: Case Report

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A case of Wegener's granulomatosis (WG) coexisting with Takayasu's arteritis (TA) in a 12-year-old girl is presented. She presented with fulminant and severe renal insufficiency due to crescentic glomerulonephritis. At autopsy, aortic lesions of Takayasu's arteritis coexisted with pulmonary and renal findings of WG, and the patient's serum at autopsy had an elevated level of antineutrophil cytoplasmic antibodies (ANCA). Both forms of vasculitis have been thought to be triggered by infectious agents and it is postulated that this occurrence accounts for the coexistence of the two forms of vasculitis in this case.

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Received February 20, 1998; accepted August 31, 1998.

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Mejia-Hernandez, C., Alvarez-Mendoza, A. & DeLeon-Bojorge, B. Takayasu's Arteritis Coexisting with Wegener's Granulomatosis in a Teenager with Renal Insufficiency: Case Report. Pediatr. Dev. Pathol. 2, 385–388 (1999). https://doi.org/10.1007/s100249900139

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  • DOI: https://doi.org/10.1007/s100249900139

  • Key words: Takayasu's arteritis, Wegener's granulomatosis, overlap syndrome, crescentic glomerulonephritis