Skip to main content
Log in

Zimmermann-Laband Syndrome in an Infant With an Atypical Histologic Finding

Pediatric and Developmental Pathology

Abstract

Zimmermann-Laband syndrome is an inherited disorder that is characterized by abnormalities of the head, face, hands, and feet. Most children with this disorder have generalized hypertrichosis, large gingivae, and hypoplasia of the fingernails and toenails. We report a male infant who exhibited typical features of Zimmermann-Laband syndrome with an unusual histopathologic finding. Excised tissue from the infant’s gingivae showed papillary projections that were composed of hyperplastic stratified squamous epithelium with different amounts of keratinization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Stefanova M, Atanassov D, Krastev T, Fuchs S, Kutsche K. Zimmermann-Laband syndrome associated with a balanced reciprocal translocation t(3;8)(p21.2;q24.3) in mother and daughter: molecular cytogenetic characterization of the breakpoint regions. Am J Med Genet 2003;117:289–294

    Google Scholar 

  2. Lacombe D, Bioulac-Sage P, Sibout M, Daussac E, Lesure F, Manchart JP, Battin J. Congenital marked hypertrichosis and Laband syndrome in a child: overlap between the gingival fibromatosis-hypertrichosis and Laband syndromes. Genet Couns 1994;5:251–256

    PubMed  CAS  Google Scholar 

  3. Robertson SP, Lipp H, Bankier A. Zimmermann-Laband syndrome in an adult. Long-term follow-up of a patient with vascular and cardiac complications. Am J Med Genet 1998;78:160–164

    Article  PubMed  CAS  Google Scholar 

  4. Van Buggenhout GJ, Brunner HG, Trommelen JC, Hamel BC. Zimmermann-Laband syndrome in a patient with severe mental retardation. Genet Couns 1995;4:321–327

    Google Scholar 

  5. Bakaeen G, Scully C. Hereditary gingival fibromatosis in a family with the Zimmermann-Laband syndrome. J Oral Pathol Med 1991;20:457–459

    PubMed  CAS  Google Scholar 

  6. Dumic M, Crawford C, Ivkovic I, Cvitanovic M, Batinica S. Zimmerman-Laband syndrome: an unusually early presentation in a newborn girl. Croat Med J 1999;40:102–103

    PubMed  CAS  Google Scholar 

  7. Holzhausen M, Goncalves D, Correa Fde O, Spolidorio LC, Rodrigues VC, Orrico SR. A case of Zimmermann-Laband syndrome with supernumerary teeth. J Periodontol 2003;74:1225–1230

    Article  PubMed  Google Scholar 

  8. Witkop CJ Jr. Heterogeneity in gingival fibromatosis. Birth Defects Orig Article Ser 1971;7:210–221

    Google Scholar 

  9. Laband PF, Habib G, Humphreys GS. Hereditary gingival fibromatosis.Report of an affected family with associated splenomegaly and skeletal and soft-tissue abnormalities. Oral Surg 1964;31:691–695

    Google Scholar 

  10. Alavander G. Elephantiasis gingivae: report of an affected family with associated hepatomegaly, soft tissue and skeletal abnormalities. J All India Dent Assoc 1965;37:349–353

    Google Scholar 

  11. Pfeifer RA, Seemanova E, Suss J, Mussig D, Tietze HU. Das Syndrom von Zimmermann-Laband. Klin Pediatr 1992;204:1–5

    Article  Google Scholar 

  12. Chadwich B, Hunter B, Hunter L, Aldred M, Wilkie A. Laband syndrome. Report on two cases, review of the literature, and identification of additional manifestations. Oral Surg Oral Med Oral Pathol 1994;78:57–63

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mehmet Emre Atabek.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Atabek, M.E., Pirgon, O., Sert, A. et al. Zimmermann-Laband Syndrome in an Infant With an Atypical Histologic Finding. Pediatr Dev Pathol 8, 654–657 (2005). https://doi.org/10.1007/s10024-005-0048-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10024-005-0048-1

Keywords

Navigation