ABSTRACT
Tissue and cellular elements generally attributed to the central nervous system (CNS) are infrequently found in areas outside the CNS proper. Most of these lesions contain predominantly glial tissue. In rare instances, heterotopic CNS tissue is found in the scalp, many associated with an intracranial connection and overlying skin and hair anomalies. In follow-up of these patients, development is normal. We present a case of a temporal scalp mass in a 19-month-old girl with a seizure disorder beginning at about age 1 year. At the time of excision, the mass was not associated with intracranial connection or overlying cutaneous abnormalities and demonstrated abundant neuronal and glial elements with features of dysplastic CNS tissue. We speculate that, in certain circumstances, aberrantly localized CNS tissue may be related to abnormal CNS development.
References
Ofodile FA, Aghadiuno PU, Oyemade O, Adebonojo T. Heterotopic brain in the tongue. Plast Reconstr Surg 1982;69:120–124
Ibekwe AO, Ikerionwu SE. Heterotopic brain tissue in the palate. J Laryngol Otol 1982;96:1155–1158
Okulski EG, Biemer JJ, Alonso WA. Heterotopic pharyngeal brain. Arch Otolaryngol 1981;107:385–386
Faerber EN, Swartz JD. Heterotopic pharyngeal brain. AJNR 1983;4:989–990
Madjidi A, Couly G. Heterotopic neuroglial tissue of the face. Report of six cases and review of the literature. Oral Surg Oral Med Oral Pathol 1993;76:284–288
Zook EG, Nickey WM, Pribaz JJ. Heterotopic brain tissue in the scalp. Plast Reconstr Surg 1984;73:660–663
Van Geertruyden JP, Fourez TJ, Hansen P, Heimann PE, Brion JP. Heterotopic brain tissue in the scalp. Br J Plast Surg 1995;48:332–334
Tanii T, Hamada T. A variant of encephalomeningocele: heterotopic brain tissue on the scalp. Dermatologica 1984;169:354–358
Pryce DW, Khine M, Verbov JL, Van Velzen D. Scalp cyst with heterotopic brain tissue. Br J Dermatol 1993;129:183–185
McGarr PL, Ramdial PK, Madaree A. Heterotopic brain tissue in the scalp. Plast Reconstr Surg 2001;107:497–500
Drolet BA, Clowry L Jr, McTigue MK, Esterly NB. The hair collar sign: marker for cranial dysraphism. Pediatrics 1995;96:309–313
Commens C, Rogers M, Kan A. Heterotropic brain tissue presenting as bald cysts with a collar of hypertrophic hair. The ‘hair collar’ sign. Arch Dermatol 1989;125:1253–1256
Ellison D. Neuropathology. London: Mosby, 1998
Antel SB, Bernasconi A, Bernasconi N et al. Computational models of MRI characteristics of focal cortical dysplasia improve lesion detection. Neuroimage 2002;17:1755–1760
Choi BH, Matthias SC. Cortical dysplasia associated with massive ectopia of neurons and glial cells within the subarachnoid space. Acta Neuropathol (Berl) 1987;73:105–109
Golden JA. Cell migration and cerebral cortical development. Neuropathol Appl Neurobiol 2001;27:22–28
Blatt J, Hamilton RL. Neurodevelopmental anomalies in children with neuroblastoma. Cancer 1998;82:1603–1608
Hendrickson M, Faye-Petersen O, Johnson DG. Cystic and solid heterotopic brain in the face and neck: a review and report of an unusual case. J Pediatr Surg 1990;25:766–768
Theaker JM, Fletcher CD. Heterotopic glial nodules: a light microscopic and immunohistochemical study. Histopathology 1991;18:255–260
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Ozolek, J.A., Losee, J.E., Lopes, T.C. et al. Temporal Soft Tissue Glioneuronal Heterotopia in a Child with a Seizure Disorder: Case Report and Review of the Literature. Pediatr Dev Pathol 8, 673–679 (2005). https://doi.org/10.1007/s10024-005-0007-x
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DOI: https://doi.org/10.1007/s10024-005-0007-x