Testicular Mixed Germ Cell Tumor With Polyembryoma Component in Brothers

Abstract

We report the case of a 17-year-old male with a testicular tumor and high serum levels of α-fetoprotein. The patient was treated with surgery followed by combination chemotherapy with bleomycin, etoposide, and cisplatin. Histologic examination showed features of a mixed germ cell tumor composed of mature teratoma, immature teratoma, embryonal carcinoma, yolk sac tumor, and polyembryoma. He is currently well, and his serum levels of α-fetoprotein have been normal more than 5 months after treatment. His brother, aged 17 years at the time, had a similar tumor removed from the right testicle 5 years previously.

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References

  1. 1.

    RW Evans (1957) ArticleTitleDevelopmental stages of embryo-like bodies in teratoma testis J Clin Pathol 10 31–39 Occurrence Handle1:STN:280:CyiD2M3jsFA%3D Occurrence Handle13406071

    CAS  PubMed  Google Scholar 

  2. 2.

    N Nakashima S Murakami T Fukatsu et al. (1988) ArticleTitleCharacteristic of “embryoid body” in human gonadal germ cell tumors Hum Pathol 19 1144–1154 Occurrence Handle1:STN:280:BiaD3cnmt1c%3D Occurrence Handle2844644

    CAS  PubMed  Google Scholar 

  3. 3.

    PJ Woodward A Heidenreich LHJ Looijenja et al. (2004) Tumours of the testis and paratesticular tissue JN Eble G Sauter JI Epstein IA Sesterhenn (Eds) Tumours of the Urinary System and Male Genital Organs. World Health Organization Classification of Tumours IARC Press Lyon 246–249

    Google Scholar 

  4. 4.

    A Cornet J Bultinck G Declercq (1985) ArticleTitlePolyembryoma of testis Acta Urol Belg 53 107–114 Occurrence Handle1:STN:280:BiqC1Mrns1E%3D Occurrence Handle2986435

    CAS  PubMed  Google Scholar 

  5. 5.

    TM Ulbright (1993) ArticleTitleGerm cell neoplasms of testis Am J Surg Pathol 17 1075–1091

    Google Scholar 

  6. 6.

    KP Dieckmann U Pichlmeier (1997) ArticleTitleThe prevalence of familial testicular cancer: an analysis of two patient populations, a review of the literature Cancer 80 1954–1960 Occurrence Handle1:STN:280:DyaK1c%2FjtFKhtA%3D%3D Occurrence Handle9366298

    CAS  PubMed  Google Scholar 

  7. 7.

    MG Leahy S Tonks JH Moses et al. (1995) ArticleTitleCandidate regions for a testicular cancer susceptibility gene Hum Mol Genet 4 1551–1555 Occurrence Handle1:CAS:528:DyaK2MXnvVensLg%3D Occurrence Handle8541838

    CAS  PubMed  Google Scholar 

  8. 8.

    EA Rapley GP Crockford D Teare et al. (2000) ArticleTitleLocalization to Xq27 of a susceptibility gene for testicular germ-cell tumours Nat Genet 24 197–200

    Google Scholar 

  9. 9.

    FK Mostofi (1973) ArticleTitleProceedings: testicular tumors Epidemiologic, etiologic and pathologic features. Cancer 32 1186–1201

    Google Scholar 

  10. 10.

    P Exelby (1980) ArticleTitleTesticular cancer in children Cancer 45 1803–1809

    Google Scholar 

  11. 11.

    HB Marsden JM Birch R Swindell (1981) ArticleTitleGerm cell tumours of childhood: a review of 137 cases J Clin Pathol 34 879–883 Occurrence Handle1:STN:280:Bi2D3cfit1A%3D Occurrence Handle6268666

    CAS  PubMed  Google Scholar 

  12. 12.

    FK Mostofi IA Sesterhenn CJ Davis SuffixJr (1988) ArticleTitleDevelopments in histopathology of testicular germ cell tumors Urology 00 171–188

    Google Scholar 

  13. 13.

    D Vugrin A Chen P Feigl et al. (1988) ArticleTitleEmbryonal carcinoma of the testis Cancer 61 2348–2352 Occurrence Handle1:STN:280:BieB3M%2FitFc%3D Occurrence Handle3365662

    CAS  PubMed  Google Scholar 

  14. 14.

    FK Mostofi IA Sesterhenn (1998) Histological Typing of Testis Tumours, 2nd ed. World Health Organization International Histological Classification of Tumours Springer-Verlag 1998 Berlin

    Google Scholar 

  15. 15.

    MN Peralta-Venturina Particlede JY Ro NG Ordonez AG Ayala (1994) ArticleTitleDiffuse embryoma of the testis. An immunohistochemical study of two cases Am J Clin Pathol 102 402–405 Occurrence Handle7524298

    PubMed  Google Scholar 

  16. 16.

    M Marin-Padilla (1965) ArticleTitleOrigin, nature and significance of the “embryoids” of human teratomas Virchows Arch Pathol Anat Physiol Klin Med 340 105–121

    Google Scholar 

  17. 17.

    LC Stevens (1960) ArticleTitleEmbryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse Dev Biol 2 285–297 Occurrence Handle1:STN:280:CC%2BB3crislE%3D Occurrence Handle13834544

    CAS  PubMed  Google Scholar 

  18. 18.

    M Takemori R Nishimura M Yamasaki Y Kawabe K Hasegawa (1998) ArticleTitleOvarian mixed germ cell tumor composed of polyembryoma and immature teratoma Gynecol Oncol 69 260–263 Occurrence Handle1:STN:280:DyaK1czht1Cjtw%3D%3D Occurrence Handle9648599

    CAS  PubMed  Google Scholar 

  19. 19.

    JS Beck HF Fulmer ST Lee (1969) ArticleTitleSolid malignant ovarian teratoma with “embryoid bodies” and tropoblastic differentiation J Pathol 99 67–73 Occurrence Handle1:STN:280:CS%2BD28%2FjslA%3D Occurrence Handle5359224

    CAS  PubMed  Google Scholar 

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Correspondence to Sevgi Bakarı ıs.

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Bakarı ıs, S., Resı ım, S. & Tunalı ı, N. Testicular Mixed Germ Cell Tumor With Polyembryoma Component in Brothers. Pediatr Dev Pathol 8, 92–97 (2005). https://doi.org/10.1007/s10024-004-2123-4

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Keywords

  • testicular cancer
  • mixed germ cell neoplasm
  • testicle
  • polyembryoma
  • histology