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Gene Therapy for Chronic Peripheral Arterial Disease: What Role for the Vascular Surgeon?

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Annals of Vascular Surgery

Abstract

The incidence of peripheral arterial disease is rising and despite advances in clinical management, many problems remain unsolved. Better knowledge of the mechanisms and consequences associated with chronic muscle ischemia has opened the way for development of new treatment strategies, including therapeutic angiogenesis. Therapeutic angiogenesis is a promising technique based on experimental studies showing that growth factors or genes able to increase capillary density can be used to reduce the impact of muscle ischemia and increase blood flow to ischemic tissue. Enthusiasm for this technique has prompted numerous clinical trials with encouraging results, but data are still inconclusive. Optimal indications for gene therapy must be defined and further experimental progress is needed to respond to ethical issues. Therapeutic angiogenesis should be viewed as an adjunct to rather than as a competitor of current surgical revascularization techniques.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Haut-Leveque Hospital, Pessac, France

    Laurent Barandon MD & Claude Deville MD

  2. Department of Cardiology and Vascular Diseases, Haut-Leveque Hospital, INSERM Unit, Pessac, France

    Lionel Leroux MD & Thierry Couffinhal PhD

  3. Department of Vascular Surgery, Pasteur Hospital, Langon, France

    Philippe Plagnol MD & Thierry Couffinhal PhD

  4. INSERM, Pessac, France

    Laurent Barandon MD, Pascale Dufourcq PhD, Cécile Duplaa PhD & Thierry Couffinhal PhD

Authors
  1. Laurent Barandon MD
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  2. Lionel Leroux MD
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  3. Pascale Dufourcq PhD
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  4. Philippe Plagnol MD
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  5. Claude Deville MD
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  6. Cécile Duplaa PhD
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  7. Thierry Couffinhal PhD
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Correspondence to Laurent Barandon MD.

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Barandon, L., Leroux, L., Dufourcq, P. et al. Gene Therapy for Chronic Peripheral Arterial Disease: What Role for the Vascular Surgeon?. Ann Vasc Surg 18, 758–765 (2004). https://doi.org/10.1007/s10016-004-0115-5

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  • DOI: https://doi.org/10.1007/s10016-004-0115-5

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