Artificial Life and Robotics

, Volume 24, Issue 1, pp 1–5 | Cite as

Optical examination of the efficacy of contact needle therapy for chemotherapy-induced peripheral neuropathy: integration of inspection in Kampo therapy with color spectrum information

  • Keiko Ogawa-OchiaiEmail author
  • Akiko Shirai
  • Masaki Tsuda
  • Norimichi Tsumura
Special Feature: Original Article


Cancer chemotherapy-induced peripheral neuropathy (CIPN) deteriorates the patient’s quality of life, often resulting in discontinuation of treatment with potentially effective chemotherapy. Contact needle therapy (CNT) is one of the traditional Japanese acupuncture methods based on the concept of Kampo (Japanese traditional) medicine. CNT on CIPN has been considered effective empirically, but an objective evaluation has proven difficult. We have focused on the oxygen saturation besides the symptom score. We have already proposed optical path-length matrix method (OPLM) for estimating oxygen saturation of the skin, which may help in locating peripheral tissue damage, including neuronal damage. Four patients with CIPN were treated with CNT. The severity of CIPN was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) ver. 4 and FACT/GOG-Ntx before and after CNT. We also measured oxygen saturation and hemoglobin concentration at the right toe-tip. Correlations among the values were calculated as correlation coefficients. There were significantly improvements in FACT/GOG-Ntx and hemoglobin post-CNT than in pre-CNT (p < 0.05). The oxygen saturation showed broad correlation (0.5 < |r| < 1) with hemoglobin. The oxygen saturation of skin reflects tissue injury and blood stagnation status, and can help in objective evaluation by measuring skin color spectrum. CNT might be considered as one of the safe and effective alternative therapeutic options for CIPN. Our method of evaluation using skin color spectrum information integrates, in a sense, the inspection in Kampo (Japanese traditional medicine) therapy and scientific methodology.


Japanese traditional (Kampo) medicine Oxygen saturation Skin color spectrum Chemotherapy-induced peripheral neuropathy (CIPN) Contact needle therapy (CNT) Acupuncture 


  1. 1.
    Quan D, Teener JW, Farrar JT (2002) Neuromuscular dysfunction and palliative care. In: Berger AM, Portenoy RK, Weissman DE (eds) Principles & practice of palliative care & supportive oncology, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, pp 545–554Google Scholar
  2. 2.
    Kaley TJ, Deangelis LM (2009) Therapy of chemotherapy-induced peripheral neuropathy. Br J Haematol 145(1):3–14CrossRefGoogle Scholar
  3. 3.
    Sioka C, Kyritsis AP (2009) Central and peripheral nervous system toxicity of common chemotherapeutic agents. Cancer Chemother Pharmacol 63(5):761–767CrossRefGoogle Scholar
  4. 4.
    Rowinsky EK, Donehower RC (1995) Paclitaxel (taxol). N Engl J Med 332(15):1004–1014CrossRefGoogle Scholar
  5. 5.
    LoMonaco M, Milone M, Batocchi AP, Padua L, Restuccia D, Tonali P (1992) Cisplatin neuropathy: clinical course and neurophysiological findings. J Neurol 239(4):199–204CrossRefGoogle Scholar
  6. 6.
    Pasetto LM, D’Andrea MR, Rossi E, Monfardini S (2006) Oxaliplatin-related neurotoxicity: how and why? Crit Rev Oncol Hematol 59(2):159–168CrossRefGoogle Scholar
  7. 7.
    Pachman DR, Barton DL, Watson JC, Loprinzi CL (2011) Chemotherapy-induced peripheral neuropathy: prevention and treatment. Clin Pharmacol Ther 90(3):377–387CrossRefGoogle Scholar
  8. 8.
    Schroeder S, Meyer-Hamme G, Epplée S (2012) Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography. Acupunct Med 30(1):4–7CrossRefGoogle Scholar
  9. 9.
    Ogawa K, Ogawa M, Nishijima K, Tsuda M, Nishimura G (2013) Efficacy of contact needle therapy for chemotherapy-induced peripheral neuropathy. Evid Based Complement Altern Med. Google Scholar
  10. 10.
    Yamamoto S, Fujiwara I, Yamauchi M, Tsumura N, Ogawa-Ochiai K (2012) Optical path-length matrix method for estimating skin spectrum. Opt Rev 19(6):361–365CrossRefGoogle Scholar
  11. 11.
    Sato Y, Hanawa T, Arai M et al (2005) Introduction to Kampo—Japanese traditional medicine. The Japan Society for Oriental Medicine. Elsevier, TokyoGoogle Scholar
  12. 12.
    Yamamoto S, Tsumura N, Nakaguchi T et al (2011) Regional image analysis of the tongue color spectrum. Int J Comput Assist Radiol Surg 6(1):143–152CrossRefGoogle Scholar
  13. 13.
    Yamamoto S, Tsumura N, Nakaguchi T et al (2011) Principal component vector rotation of the tongue color spectrum to predict “mibyou” (disease-oriented state). Int J Comput Assist Radiol Surg 6(2):209–215CrossRefGoogle Scholar
  14. 14.
    Yamamoto S, Ishikawa Y, Nakaguchi T et al (2012) Temporal changes in tongue color as criterion for tongue diagnosis in kampo medicine. Forsch Komplementmed 19(2):80–85CrossRefGoogle Scholar
  15. 15.
    Tsumura N, Kawabuchi M, Haneishi H, Miyake Y (2001) Mapping pigmentation in human skin from multi-channel visible spectrum image by inverse optical scattering technique. J Imaging Sci Technol 45(5):444–450Google Scholar
  16. 16.
    Akaho R, Hirose M, Tsumura N (2018) Evaluation of the robustness of estimating five components from a skin spectral image. Opt Rev 25(2):81–189Google Scholar
  17. 17.
    Colson K, Doss DS, Swift R, Tariman J, Thomas TE (2004) Bortezomib, a newly approved proteasome inhibitor for the treatment of multiple myeloma: nursing implications. Clin J Oncol Nurs 8:473–480CrossRefGoogle Scholar
  18. 18.
    Kanda Y (2013) Investigation of the freely available easy-to-use software EZR for medical statistics. Bone Marrow Transplant 48:452–458CrossRefGoogle Scholar
  19. 19.
    Yamamoto S, Tsumura N, Yoshizaki T, Ogawa K (2014) Oxygen saturation of skin reflects blood flow and stagnation. Artif Life Robot 19:170–175CrossRefGoogle Scholar

Copyright information

© ISAROB 2018

Authors and Affiliations

  • Keiko Ogawa-Ochiai
    • 1
    Email author
  • Akiko Shirai
    • 1
  • Masaki Tsuda
    • 1
    • 3
  • Norimichi Tsumura
    • 1
    • 2
  1. 1.Department of Japanese Traditional (Kampo) MedicineKanazawa University HospitalKanazawaJapan
  2. 2.Graduate School of EngineeringChiba UniversityChibaJapan
  3. 3.Mukeido Acupuncture and Moxibustion officeToyamaJapan

Personalised recommendations