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Epithelioid inflammatory myofibroblastic sarcoma with VCL–ALK fusion of central nervous system: case report and brief review of the literature

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A Correction to this article was published on 04 January 2022

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Abstract

Epithelioid inflammatory myofibroblastic sarcomas are an aggressive variant of inflammatory myofibroblastic tumor described primarily in the abdomen and less commonly in pulmonary location. The anaplastic lymphoma kinase (ALK) fusion partners described in this tumor include RANB2, RRBP1 and EML4. While rare examples of inflammatory myofibroblastic tumors have been described in the central nervous system, the epithelioid variant has never been described. The ALK–VCL fusion has been described in renal cell carcinoma, high-grade glioma and epithelioid fibrous histiocytoma but has not been described in epithelioid inflammatory myofibroblastic sarcoma or even inflammatory myofibroblastic tumor. Herein, we report the first case of epithelioid inflammatory myofibroblastic sarcoma in the central nervous system as well as the first case with VCL as the fusion partner for ALK.

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Acknowledgements

The authors thank Kim-Ahn Vu for her assistance on Fig. 2.

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Authors and Affiliations

  1. Keck Medical Center, University of Southern California, Los Angeles, CA, USA

    Shefali Chopra

  2. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Nolan Maloney & Wei Lien Wang

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  1. Shefali Chopra
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  2. Nolan Maloney
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  3. Wei Lien Wang
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Contributions

SC: conceptualization and design, literature review, material collection, writing and editing the manuscript. NM: material collection, writing—editing the manuscript. W-LW: conceptualization, literature review, writing—editing the manuscript. All the authors have agreed with submission of this manuscript in present and subsequent form.

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Correspondence to Shefali Chopra.

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Chopra, S., Maloney, N. & Wang, W.L. Epithelioid inflammatory myofibroblastic sarcoma with VCL–ALK fusion of central nervous system: case report and brief review of the literature. Brain Tumor Pathol 39, 35–42 (2022). https://doi.org/10.1007/s10014-021-00416-z

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