Brain Tumor Pathology

, Volume 35, Issue 1, pp 36–40 | Cite as

Enchondromatosis-associated oligodendroglioma: case report and literature review

  • Takamune Achiha
  • Hideyuki AritaEmail author
  • Naoki Kagawa
  • Tsuyoshi Murase
  • Jun-ichiro Ikeda
  • Eiichi Morii
  • Yonehiro Kanemura
  • Yasunori Fujimoto
  • Haruhiko Kishima
Case Report


Enchondromatosis is a rare skeletal disorder characterized by the development of multiple enchondromas, which can also manifest non-cartilage tumors including gliomas. Here, we describe a genetic analysis of a low-grade glioma that developed in an enchondromatosis case. A 32-year-old man with a long history of enchondromatosis developed a left frontal tumor. The histopathological findings of his surgical specimen revealed characteristics of a low-grade glioma with an IDH1 c.395G>A (R132H) mutation and 1p/19q codeletion, which led to a definitive diagnosis of oligodendroglioma. A common point mutation in IDH1 (R132H) was detected in the patient’s enchondroma and glioma-matched pair specimens. To the best of our knowledge, this is the first case of molecularly confirmed oligodendroglioma associated with enchondromatosis. Furthermore, identification of a common IDH1 mutation in enchondroma and oligodendroglioma-matched pair specimens supports the hypothesis that IDH1/2 mosaicism initiates tumorigenesis.


Enchondromatosis Oligodendroglioma 1p/19q codeletion IDH1/2 mosaicism 



This work was supported by JSPS KAKENHI Grant Number 16K20006 (H.A.). The authors thank Ms. Ema Yoshioka, Mr. Daisuke Kanematsu, and Ms. Tomoko Shofuda (Institute for Clinical Research, Osaka National Hospital) for generous assistance in genetic tests.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Japan Society of Brain Tumor Pathology 2017

Authors and Affiliations

  • Takamune Achiha
    • 1
  • Hideyuki Arita
    • 1
    Email author
  • Naoki Kagawa
    • 1
  • Tsuyoshi Murase
    • 2
  • Jun-ichiro Ikeda
    • 3
  • Eiichi Morii
    • 3
  • Yonehiro Kanemura
    • 4
    • 5
  • Yasunori Fujimoto
    • 1
  • Haruhiko Kishima
    • 1
  1. 1.Department of NeurosurgeryOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Department of Orthopedic SurgeryOsaka University Graduate School of MedicineOsakaJapan
  3. 3.Department of PathologyOsaka University Graduate School of MedicineOsakaJapan
  4. 4.Division of Regenerative Medicine, Institute for Clinical ResearchOsaka National Hospital, National Hospital OrganizationOsakaJapan
  5. 5.Kansai Molecular Diagnosis Network for Central Nervous System TumorsOsakaJapan

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