Skip to main content
Log in

RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging

  • Letter to the Editor
  • Published:
Brain Tumor Pathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Ellison DW, Kocak M, Figarella-Branger D et al (2011) Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts. J Negat Results Biomed 10:7. doi:10.1186/1477-5751-10-7

    Article  PubMed  PubMed Central  Google Scholar 

  2. Pajtler KW, Witt H, Sill M et al (2015) Molecular classification of ependymal tumors across All CNS compartments, histopathological grades, and age groups. Cancer Cell 27:728–743. doi:10.1016/j.ccell.2015.04.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 131:803–820. doi:10.1007/s00401-016-1545-1

    Article  PubMed  Google Scholar 

  4. Kralik SF, Taha A, Kamer AP et al (2014) Diffusion imaging for tumor grading of supratentorial brain tumors in the first year of life. AJNR Am J Neuroradiol 35:815–823. doi:10.3174/ajnr.A3757

    Article  CAS  PubMed  Google Scholar 

  5. Yamasaki F, Kurisu K, Satoh K et al (2005) Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology 235:985–991. doi:10.1148/radiol.2353031338

    Article  PubMed  Google Scholar 

  6. Parker M, Mohankumar KM, Punchihewa C et al (2014) C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Nature 506:1–16. doi:10.1038/nature13109

    Article  Google Scholar 

  7. Kiefel H, Bondong S, Hazin J et al (2012) L1CAM: a major driver for tumor cell invasion and motility. Cell Adh Migr 6:374–384. doi:10.4161/cam.20832

    Article  PubMed  PubMed Central  Google Scholar 

  8. Merchant TE, Fouladi M (2005) Ependymoma: new therapeutic approaches including radiation and chemotherapy. J Neurooncol 75:287–299. doi:10.1007/s11060-005-6753-9

    Article  PubMed  Google Scholar 

  9. Yamasaki F, Takayasu T, Nosaka R et al (2017) Development of cystic malacia after high-dose cranial irradiation of pediatric CNS tumors in long-term follow-up. Childs Nerv Syst 33:957–964. doi:10.1007/s00381-017-3400-7

    Article  PubMed  Google Scholar 

  10. Takizawa D, Mizumoto M, Yamamoto T et al (2017) A comparative study of dose distribution of PBT, 3D-CRT and IMRT for pediatric brain tumors. Radiat Oncol 12:40. doi:10.1186/s13014-017-0775-2

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors thank Japan Children’s Cancer Group for providing a central diagnostic service supported by the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and development, AMED.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shumpei Onishi.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Onishi, S., Yamasaki, F., Nakano, Y. et al. RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging. Brain Tumor Pathol 35, 41–45 (2018). https://doi.org/10.1007/s10014-017-0301-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10014-017-0301-0

Navigation