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The clinicopathological features of liponeurocytoma

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Abstract

To discuss the clinicopathological features of liponeurocytoma, we retrospectively reviewed three liponeurocytoma cases and compared their immunophenotypes and genotypes with those of similar tumors. Furthermore, we reviewed the literature and compared the similarities and differences between cerebellar and intraventricular liponeurocytomas. Two cerebellar and one intraventricular liponeurocytomas were included in the present study. The liponeurocytomas comprised small tumor cells and lipomatous cells. The tumor cells expressed SYN, MAP-2, and NeuN. One case showed atypical histological features. By reviewing the literature, we found that cerebellar liponeurocytoma tended to be more common in females, whereas the converse was true for intraventricular liponeurocytoma. Compared with cerebellar liponeurocytoma, intraventricular liponeurocytoma was more commonly noted in younger adult patients. A high MIB-1 index (>10%) and incomplete tumor resection might represent adverse prognostic factors in patients with liponeurocytoma. We suggest that ‘central liponeurocytoma’ should be used to include all putative liponeurocytoma sites. The present study identified several morphological, immunohistochemical, and genetic features that may aid in the differential diagnosis of liponeurocytoma. In addition, surgery should be the preferred treatment, and complete tumor resection should be the goal. Additional cases with long-term follow-up are needed to develop optimal management protocols for liponeurocytoma.

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References

  1. Bechtel JT, Patton JM, Takei Y (1978) Mixed mesenchymal and neuroectodermal tumor of the cerebellum. Acta Neuropathol 41:261–263

    Article  CAS  PubMed  Google Scholar 

  2. Horstmann S, Perry A, Reifenberger G et al (2004) Genetic and expression profiles of cerebellar liponeurocytomas. Brain Pathol 14:281–289

    Article  CAS  PubMed  Google Scholar 

  3. Kleihues P, Louis DN, Scheithauer BW et al (2002) The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61:215–229

    Article  PubMed  Google Scholar 

  4. Giangaspero F, Cenacchi G, Roncaroli F et al (1996) Medullocytoma (lipidized medulloblastoma). A cerebellar neoplasm of adults with favorable prognosis. Am J Surg Pathol 20:656–664

    Article  CAS  PubMed  Google Scholar 

  5. Alkadhi H, Keller M, Brandner S et al (2001) Neuroimaging of cerebellar liponeurocytoma. Case report. J Neurosurg 95:324–331

    Article  CAS  PubMed  Google Scholar 

  6. George DH, Scheithauer BW (2001) Central liponeurocytoma. Am J Surg Pathol 25:1551–1555

    Article  CAS  PubMed  Google Scholar 

  7. Jenkinson MD, Bosma JJ, Du Plessis D et al (2003) Cerebellar liponeurocytoma with an unusually aggressive clinical course: case report. Neurosurgery 53:1425–1428

    Article  PubMed  Google Scholar 

  8. Jouvet A, Lellouch-Tubiana A, Boddaert N et al (2005) Fourth ventricle neurocytoma with lipomatous and ependymal differentiation. Acta Neuropathol 109:346–351

    Article  PubMed  Google Scholar 

  9. Kleihues P, Chimelli L, Giangaspero F et al (2007) Cerebellar liponeurocytoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO Classification of Tumors of the Central Nervous System. IARC, Lyon, pp 110–112

    Google Scholar 

  10. Wang KE, Ni M, Wang L, et al (2016) Cerebellar liponeurocytoma: a case report and review of the literature. Oncol Lett 11:1061–1064

    CAS  PubMed  Google Scholar 

  11. Oudrhiri MY, Raouzi N, El Kacemi I, et al (2014) Understanding cerebellar liponeurocytomas: case report and literature review. Case Rep Neurol Med 2014:186826

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Fung KM, Fang W, Norton RE et al (2003) Cerebellar central liponeurocytoma. Ultrastruct Pathol 27:109–114

    Article  PubMed  Google Scholar 

  13. Hortobágyi T, Bódi I, Lantos PL (2007) Adult cerebellar liponeurocytoma with predominant pilocytic pattern and myoid differentiation. Neuropathol Appl Neurobiol 33:121–125

    Article  PubMed  Google Scholar 

  14. Takami H, Mukasa A, Ikemura M et al (2015) Findings from positron emission tomography and genetic analyses for cerebellar liponeurocytoma. Brain Tumor Pathol 32:210–215

    Article  PubMed  Google Scholar 

  15. Ben Nsir A, Ben Said I, Hammami N et al (2014) Cerebellar liponeurocytoma with extracranial extension: case report. Neurol Neurochir Pol 48:458–462

    CAS  PubMed  Google Scholar 

  16. Kakkar A, Sable M, Suri V et al (2015) Cerebellar liponeurocytoma, an unusual tumor of the central nervous system–ultrastructural examination. Ultrastruct Pathol 39:419–423

    Article  PubMed  Google Scholar 

  17. Konovalov AN, Konovalov NA, PronIN IN, et al (2015) Multiple primary liponeurocytoma of the central nervous system. Zh Vopr Neirokhir Im N N Burdenko 79:87–96 (Article in Russian)

    Article  CAS  PubMed  Google Scholar 

  18. Scoppetta TL, Brito MC, Prado JL et al (2015) Multifocal cerebellar liponeurocytoma. Neurology 85:1912

    Article  PubMed  Google Scholar 

  19. Wolf A, Alghefari H, Krivosheya D et al (2016) Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report. J Neurosurg 125:57–61

    Article  PubMed  Google Scholar 

  20. Pikis S, Fellig Y, Margolin E (2016) Cerebellar liponeurocytoma in two siblings suggests a possible familial predisposition. J Clin Neurosci 32:154–156

    Article  PubMed  Google Scholar 

  21. Karabagli P, Sav A, Pamir N (2014) Does “cerebellar liponeurocytoma” always reflect an expected site? An unusual case with a review of the literature. Folia Neuropathol 52:101–105

    Article  PubMed  Google Scholar 

  22. Owler BK, Makeham JM, Shingde M et al (2005) Cerebellar liponeurocytoma. J Clin Neurosci 12:326–329

    Article  PubMed  Google Scholar 

  23. Soylemezoglu F, Soffer D, Onol B et al (1996) Lipomatous medulloblastoma in adults. A distinct clinicopathological entity. Am J Surg Pathol 20:413–418

    Article  CAS  PubMed  Google Scholar 

  24. Alleyne CH Jr, Hunter S, Olson JJ et al (1998) Lipomatous glioneurocytoma of the posterior fossa with divergent differentiation: case report. Neurosurgery 42:639–643

    Article  PubMed  Google Scholar 

  25. Elshihabi S, Husain M, Linskey M (2003) Lipomatous medulloblastoma: a rare adult tumor variant with a uniquely favorable prognosis. Surg Neurol 60:566–570

    Article  PubMed  Google Scholar 

  26. Patel N, Fallah A, Provias J et al (2009) Cerebellar liponeurocytoma. Can J Surg 52:E117–E119

    PubMed  PubMed Central  Google Scholar 

  27. Aker FV, Ozkara S, Eren P et al (2005) Cerebellar liponeurocytoma/lipidized medulloblastoma. J Neurooncol 71:53–59

    Article  PubMed  Google Scholar 

  28. Chung SB, Suh YL, Lee JI (2012) Cerebellar liponeurocytoma with an unusually aggressive histopathology: case report and review of the literature. J Korean Neurosurg Soc 52:250–253

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kachhara R, Bhattacharya RN, Nair S et al (2003) Liponeurocytoma of the cerebellum–a case report. Neurol India 51:274–276

    CAS  PubMed  Google Scholar 

  30. Rajesh LS, Vasishta RK, Chhabra R et al (2003) Case report: central liponeurocytoma. Neuropathol Appl Neurobiol 29:511–513

    Article  CAS  PubMed  Google Scholar 

  31. Chakraborti S, Mahadevan A, Govindan A et al (2011) Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature. J Neurooncol 103:121–127

    Article  PubMed  Google Scholar 

  32. Pankaj R, Jindal A, Banerjee AK (2010) Liponeurocytoma of lateral ventricle. Neurol India 58:805–806

    Article  PubMed  Google Scholar 

  33. Montagna N, Moreira D, Vaz LC et al (2002) Cerebellar liponeurocytoma: a newly recognized clinico-pathological entity. Arq Neuropsiquiatr 60(3–B):725–729

    Article  PubMed  Google Scholar 

  34. Pasquale G, Maria BA, Vania P et al (2009) Cerebellar liponeurocytoma: an updated follow-up of a case presenting histopathological and clinically aggressive features. Neurol India 57:194–196

    Article  PubMed  Google Scholar 

  35. Louis DN, Ohgaki H, Wiestler OD et al (eds) (2016) WHO classification of tumors of the central nervous system (revised 4th edn). IARC, Lyon

  36. Ellison DW, Zygmunt SC, Weller RO (1993) Neurocytoma/lipoma (neurolipocytoma) of the cerebellum. Neuropathol Appl Neurobiol 19:95–98

    Article  CAS  PubMed  Google Scholar 

  37. Limaiem F, Bellil S, Chelly I et al (2009) Recurrent cerebellar liponeurocytoma with supratentorial extension. Can J Neurol Sci 36:662–665

    Article  PubMed  Google Scholar 

  38. Anghileri E, Eoli M, Paterra R et al (2012) FABP4 is a candidate marker of cerebellar liponeurocytomas. J Neurooncol 108:513–519

    Article  CAS  PubMed  Google Scholar 

  39. Cacciola F, Conti R, Taddei GL et al (2002) Cerebellar liponeurocytoma. Case report with considerations on prognosis and management. Acta Neurochir (Wien) 144:829–833

    Article  CAS  Google Scholar 

  40. Châtillon CE, Guiot MC, Roberge D, LeBlanc R (2009) Cerebellar liponeurocytoma with high proliferation index: treatment options. Can J Neurol Sci 36:658–661

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by Grants from the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03) and Beijing Institute for Brain Disorders (BIBD-PXM2013_014226_07_000084).

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Authors and Affiliations

  1. Department of Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Brain Tumor, Beijing, 100050, China

    Li Xu, Jiang Du, Junmei Wang, Jingyi Fang, Zhaoxia Liu, Yanjiao He & Guilin Li

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  1. Li Xu
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  2. Jiang Du
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  3. Junmei Wang
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  7. Guilin Li
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Correspondence to Guilin Li.

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Xu, L., Du, J., Wang, J. et al. The clinicopathological features of liponeurocytoma. Brain Tumor Pathol 34, 28–35 (2017). https://doi.org/10.1007/s10014-017-0279-7

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