Skip to main content
Log in

Glioma-like proliferation in a cortical hamartoma of tuberous sclerosis complex

  • Letter to the Editor
  • Published:
Brain Tumor Pathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Lopes MBS, Wiestler OD, Stemmer-Rachamimov AO, Sharma MC (2007) Tuberous sclerosis complex and subependymal giant cell astrocytoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system. IARC, Lyon, pp 218–221

    Google Scholar 

  2. Fischer I, Cunliffe C, Bollo RJ, Weiner HL, Devinsky O, Ruiz-Tachiquin ME, Venuto T, Pearlman A, Chiriboga L, Schneider RJ, Ostrer H, Miller DC (2008) Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex. Acta Neuropathol 116:67–77

    Article  CAS  PubMed  Google Scholar 

  3. Blümcke I, Luyken C, Urbach H, Schramm J, Wiestler OD (2004) An isomorphic subtype of long-term epilepsy-associated astrocytomas associated with benign prognosis. Acta Neuropathol 107:381–388

    Article  PubMed  Google Scholar 

  4. Paulus W (2009) GFAP, Ki67 and IDH1: perhaps the golden triad of glioma immunohistochemistry. Acta Neuropathol 118:603–604

    Article  PubMed  Google Scholar 

  5. Liu XY, Gerges N, Korshunov A, Sabha N, Khuong-Quang DA, Fontebasso AM, Fleming A, Hadjadj D, Schwartzentruber J, Majewski J, Dong Z, Siegel P, Albrecht S, Croul S, Jones DT, Kool M, Tonjes M, Reifenberger G, Faury D, Zadeh G, Pfister S, Jabado N (2012) Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol 124:615–625

    Article  CAS  PubMed  Google Scholar 

  6. Cunliffe CH, Fischer I, Monoky D, Law M, Revercomb C, Elrich S, Kopp MJ, Zagzag D (2009) Intracranial lesions mimicking neoplasms. Arch Pathol Lab Med 133:101–123

    PubMed  Google Scholar 

  7. Annovazzi L, Mellai M, Caldera V, Valente G, Tessitore L, Schiffer D (2009) mTOR, S6 and AKT expression in relation to proliferation and apoptosis/autophagy in glioma. Anticancer Res 29:3087–3094

    CAS  PubMed  Google Scholar 

  8. Mueller S, Phillips J, Onar-Thomas A, Romero E, Zheng S, Wiencke JK, McBride SM, Cowdrey C, Prados MD, Weiss WA, Berger MS, Gupta N, Haas-Kogan DA (2012) PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome. Neuro Oncol 14:1146–1152

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Al-Saleem T, Wessner LL, Scheithauer BW, Patterson K, Roach ES, Dreyer SJ, Fujikawa K, Bjornsson J, Bernstein J, Henske EP (1998) Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex. Cancer 83:2208–2216

    Article  CAS  PubMed  Google Scholar 

  10. Padmalatha C, Harruff RC, Ganick D, Hafez GB (1980) Glioblastoma multiforme with tuberous sclerosis. Report of a case. Arch Pathol Lab Med 104:649–650

    CAS  PubMed  Google Scholar 

  11. Stenzel W, Franitza M, Becker AJ, Montesinos-Rongen M, Lohr M, Lee JY, Rohn G, Miletic H, Deckert M (2007) A 30-year-old patient with tuberous sclerosis. Brain Pathol 17:333–334

    Article  PubMed  Google Scholar 

  12. Eren S, Polat P, Erman Z (2002) An unusual tuberous sclerosis case presenting with fibrillary astrocytoma. Pediatr Neurosurg 37:118–121

    Article  PubMed  Google Scholar 

  13. Thom M, Blumcke I, Aronica E (2012) Long-term epilepsy-associated tumors. Brain Pathol 22:350–379

    Article  PubMed  Google Scholar 

  14. Crino PB (2004) Molecular pathogenesis of tuber formation in tuberous sclerosis complex. J Child Neurol 19:716–725

    PubMed  Google Scholar 

  15. Crino PB (2013) Evolving neurobiology of tuberous sclerosis complex. Acta Neuropathol 125:317–332

    Article  PubMed  Google Scholar 

  16. Kotulska K, Borkowska J, Jozwiak S (2013) Possible prevention of tuberous sclerosis complex lesions. Pediatrics 132:e239–e242

    Article  PubMed  Google Scholar 

  17. Tillema JM, Leach JL, Krueger DA, Franz DN (2012) Everolimus alters white matter diffusion in tuberous sclerosis complex. Neurology 78:526–531

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ekkehard Hewer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hewer, E., Mariani, L. & Vajtai, I. Glioma-like proliferation in a cortical hamartoma of tuberous sclerosis complex. Brain Tumor Pathol 32, 76–78 (2015). https://doi.org/10.1007/s10014-014-0185-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10014-014-0185-1

Keywords

Navigation