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Primary CNS lymphoma arising in the region of the optic nerve presenting as loss of vision: 2 case reports, including a patient with a massive intracerebral hemorrhage

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Abstract

We report 2 cases of primary central nervous system (CNS) lymphoma arising in the region of the optic nerve. For both patients, diagnosis of lymphoma was impossible without histological examination because of the rarity of the lymphoma location. The first case involved an 84-year-old woman who developed loss of vision and hypopituitarism. Intraoperative finding was optic glioma; histological diagnosis was diffuse large B cell lymphoma, however. The second case involved a 67-year-old man who developed loss of vision. The pre-surgical diagnosis was optic nerve neuritis; this was then revised to granuloma. The tumor arose in the optic nerve. Methotrexate and rituximab were administered and the patient remained in complete remission for 3 years. However, a sudden intratumoral hemorrhage occurred. Although most of the lymphoma cells obtained from the initial surgery were negative for vascular endothelial growth factor (VEGF) immunoreactivity, high levels of VEGF immunoreactivity in lymphoma cells was detected in the specimen obtained after intratumoral bleeding at recurrence, and correlation between VEGF reactivity and tumor recurrence was suggested. To date, primary CNS lymphomas with intracerebral hemorrhage have been reported in 3 cases only, and a correlation between intratumoral hemorrhage and the degree of VEGF expression has been suggested. VEGF also might have predictive significance for recurrence.

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Acknowledgment

The authors thank Drs. T. Matsushima, S. Nishimura, K. Kubota, S. Okuyama, M. Tomii, J. Mizuno, Department of Neurosurgery, Southern Tohoku General Hospital for their cooperation of immunohistochemical staining.

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Author notes

  1. Junko Matsuyama

    Present address: Department of Neurosurgery, Southern Tohoku General Hospital, 1-2-5, Satonomori, Iwanuma, Miyagi, 989-2423, Japan

Authors and Affiliations

  1. Department of Neurosurgery, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan

    Junko Matsuyama, Masahiro Ichikawa, Taku Sato, Yugo Kishida, Keiko Oda, Takuya Maeda, Masayuki Yamada, Yosuke Kuromi, Yuka Matsumoto, Hitoshi Ando, Jun Sakuma & Kiyoshi Saito

  2. Department of Neurosurgery, Minamisoma City General Municipal Hospital, 2-54-6, Takami, Haramachi, Minamisoma, 975-0033, Japan

    Junko Matsuyama & Tomoyoshi Oikawa

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  1. Junko Matsuyama
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  2. Masahiro Ichikawa
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Correspondence to Junko Matsuyama.

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Matsuyama, J., Ichikawa, M., Oikawa, T. et al. Primary CNS lymphoma arising in the region of the optic nerve presenting as loss of vision: 2 case reports, including a patient with a massive intracerebral hemorrhage. Brain Tumor Pathol 31, 222–228 (2014). https://doi.org/10.1007/s10014-013-0159-8

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  • DOI: https://doi.org/10.1007/s10014-013-0159-8

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