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TiO2/CeO2-CePO4-decorated enzymatic glucose biosensors operating in oxygen-restrictive environments

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Abstract

The detection of glucose plays an important role in monitoring and controlling diabetes as well as its complications caused by high blood glucose levels. There have been a lot of research on glucose sensors and integrated flexible sensing platforms; however, the detection in oxygen-restrictive environments is few reported. Herein, we described the use of a novel system made up of TiO2 and ceria-cerium phosphate (CeO2-CePO4) composite nanostructures synthesized by a simple procedure to address the oxygen dependence problem confronted in the first-generation amperometric glucose biosensors. The enzymatic activity of sensors was tested in both oxygen-rich and restrictive environments. Our results showed that the resulting composites present good electro-catalytic activity towards glucose oxidation. The electrodes decorated by TiO2/CeO2-CePO4 showed a wide linear range from 0.1 to 1.7 mM with a low detection limit of 17.1 μM while the CeO2-CePO4 showed the linear range of 0.1–2.5 mM with limit of detection of 58.0 μM in oxygen-rich environment. Two types of decorated electrodes both responded to glucose well under the oxygen-restrictive environment but former showed better response performance. The as-fabricated electrodes also owned the good anti-interference, stability, and reproducibility. This strategy promises for increasing the sensitivity of glucose biosensors and provides more opportunities for operation in oxygen-restrictive conditions.

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Funding

This work was supported by the National Key Research and Development Program of China (Grant 2018YFC1901202), NSF of China (81771976), Fundamental Research Funds for the Central Universities, and the joint fund of Southeast University and Nanjing Medical University.

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Authors and Affiliations

  1. Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China

    Jiawei Xu, Ke Yang, Xuezhong Zhang, Yunfeng Lei, Xiangyu Meng & Zhifei Wang

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  1. Jiawei Xu
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  2. Ke Yang
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  3. Xuezhong Zhang
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  4. Yunfeng Lei
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  5. Xiangyu Meng
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  6. Zhifei Wang
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by JX and KY. The first draft of the manuscript was written by JX and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Zhifei Wang.

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Xu, J., Yang, K., Zhang, X. et al. TiO2/CeO2-CePO4-decorated enzymatic glucose biosensors operating in oxygen-restrictive environments. J Solid State Electrochem 25, 1937–1947 (2021). https://doi.org/10.1007/s10008-021-04956-4

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