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Polyethyleneimine-AuNPs-copper protoporphyrin nanocomposite: a novel biosensor for sensitive detection of hydrogen peroxide in human serum

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Abstract

The detection of hydrogen peroxide (H2O2) is essential due to its extensive application in bio-medical and environment. Herein, we synthesized a novel polyethyleneimine-Au nanoparticle-copper protoporphyrin (PEI-AuNPs-CuPP) nanocomposite toward H2O2 detection. Ultraviolet-visible spectrometry (UV-vis), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR) were used to characterize this nanomaterial. Analytical performance of this proposed sensor was evaluated through differential pulse voltammetry (DPV) and cyclic voltammetry (CV). It was found surprisingly that the PEI-AuNPs-CuPP-based sensor exhibited sensing for H2O2 with a detection limit of 91.74 aM. In addition, this sensor displayed superb selectivity in the presence of dopamine (DA), ascorbic acid (AA), uric acid (UA), and glucose (Glu), which held satisfactory analytical performance for the detection of H2O2 in human serum samples, indicating a promising application in biological sample analysis.

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References

  1. Tian Z, Huang W, Xu BR, Li XL, Mei YF (2018) Nano Lett 18(6):3688–3694

    Article  CAS  PubMed  Google Scholar 

  2. Kong JM, Yu XH, Hu WW, Hu Q, Shui SL, Li LZ, Han XJ, Xie HF, Zhang XJ, Wang TH (2015) Analyst 140(22):7792–7798

    Article  CAS  PubMed  Google Scholar 

  3. Haugner JC, Seelig B (2013) Chem Commun 49(66):7322–7324

    Article  CAS  Google Scholar 

  4. Shahamirifard SA, Ghaedi M, Razmi Z, Hajati S (2018) Biosens Bioelectron 114:30–36

    Article  CAS  PubMed  Google Scholar 

  5. Gao XH, He SJ, Zhang CM, Du C, Chen X, Xing W, Chen SL, Clayborne AD, Chen W (2016) Adv Sci 3:1–7

    Google Scholar 

  6. Liu MM, Liu R, Chen W (2013) Biosens. Bioelectron 45:206–212

    Article  CAS  PubMed  Google Scholar 

  7. Reed JH, Shi YL, Zhu QH, Chakraborty S, Mirts EN, Petrik ID, Bhagi-Damodaran A, Ross M, Moenne-Loccoz P, Zhang Y, Lu Y (2017) J Am Chem Soc 139(35):12209–12218

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Li JF, Peng Q, Oliver AG, Alp EE, Hu MY, Zhao JY, Sage JT, Scheidt WR (2014) J Am Chem Soc 136(52):18100–18110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gottfried JM (2015) Surf Sci Rep 70(3):259–379

    Article  CAS  Google Scholar 

  10. Buchler JW, Smith PD (1974) Angew Chem 13(11):745–745

    Article  CAS  Google Scholar 

  11. Barnett BR, Evans AL, Roberts CC, Fritsch JM (2011) Chemosphere 82(4):592–596

    Article  CAS  PubMed  Google Scholar 

  12. Collman JP, Kaplun M, Decreau RA (2006) Dalton Trans 4:554–559

    Article  Google Scholar 

  13. Apaydin DH, Seelajaroen H, Pengsakul O, Thamyongkit P, Sariciftci NS, Kunze-Liebhauser J, Portenkirchner E (2018) ChemCatChem 10(8):1793–1797

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Walkey C, Das S, Seal S, Erlichman J, Heckman K, Ghibelli L, Traversa E, McGinnis JF, Self WT (2015) Environ Sci Nano 2(1):33–53

    Article  CAS  PubMed  Google Scholar 

  15. Ju J, Chen W (2015) Anal. Chem 87(3):1903–1910

    Article  CAS  PubMed  Google Scholar 

  16. de la Rica R, Stevens MM (2012) Nat Nanotechnol 7(12):821–824

    Article  CAS  PubMed  Google Scholar 

  17. Hu M, Tian J, Lu HT, Weng LX, Wang LH (2010) Talanta 8:997–1002

    Article  CAS  Google Scholar 

  18. Mvango S, Mashazi P (2019) Mat Sci Eng C-Mater 96:814–823

    Article  CAS  Google Scholar 

  19. Zhang CM, Li L, Ju J, Chen W (2016) Electrochim Acta 210:181–189

    Article  CAS  Google Scholar 

  20. Dos Santos Pereira T, Mauruto de Oliveira GC, Santos FA, Raymundo-Pereira PA, Oliveira ONJ, Janegitz BC (2019) Talanta 194:737–744

    Article  CAS  PubMed  Google Scholar 

  21. Giorgio M, Trinei M, Migliaccio E, Pelicci PG (2007) Nat Rev Mol Cell Biol 8(9):722–728

    Article  CAS  PubMed  Google Scholar 

  22. Laloi C, Apel K, Danon A (2004) Curr Opin Plant Biol 7(3):323–328

    Article  CAS  PubMed  Google Scholar 

  23. Dehhaghi M, Tan V, Heng B, Mohammadipanah F, Guillemin GJ (2018) Neuroscience 399:1–11

    Article  CAS  PubMed  Google Scholar 

  24. Rao MS, Rao AR, Ramana KV, Sagi SR (1990) Talanta 37(7):753–755

    Article  CAS  PubMed  Google Scholar 

  25. Mori I, Takasaki K, Fujita Y, Matsuo T (1998) Talanta 47(3):631–637

    Article  CAS  PubMed  Google Scholar 

  26. Jie N, Yang J, Huang X, Zhang R, Song Z (1995) Talanta 42(11):1575–1579

    Article  CAS  PubMed  Google Scholar 

  27. Li LL, Wang YQ, Pan LJ, Shi Y, Cheng W, Shi Y, Yu GH (2015) Nano Lett 15(2):1146–1151

    Article  CAS  PubMed  Google Scholar 

  28. Tolstoy VP, Gulina LB, Golubeva AA, Ermakov SS, Gurenko VE, Navolotskaya DV, Vladimirova NI, Koroleva AV (2019) J Solid State Electrochem 23(2):573–582

    Article  CAS  Google Scholar 

  29. Nikolaev KG, Maybeck V, Neumann E, Ermakov SS, Ermolenko YE, Offenhausser A, Mourzina YG (2018) J Solid State Electrochem 22(4):1023–1035

    Article  CAS  Google Scholar 

  30. Yu Z, Park Y, Chen L, Zhao B, Jung YM, Cong Q (2015) ACS Appl Mater Interfaces 7(42):23472–23480

    Article  CAS  PubMed  Google Scholar 

  31. Cheng CF, Zhang CM, Gao XH, Zhuang ZH, Du C, Chen W (2018) Anal Chem 90(3):1983–1991

    Article  CAS  PubMed  Google Scholar 

  32. Zhang CM, Zhang RZ, Gao XH, Cheng CF, Hou L, Li XK, Chen W (2018) ACS Omega 3(1):96–105

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Kadiyala NK, Mandal BK, Ranjan S, Dasgupta N (2018) Mat Sci Eng C-Mater 93:191–205

    Article  CAS  Google Scholar 

  34. Kohout C, Santi C, Polito L (2018) Int J Mol Sci 19(11):3385

    Article  CAS  PubMed Central  Google Scholar 

  35. Otero TF, Martinez Soria LX, Schumacher J, Valero L, Pascual VH (2017) Chem Open 6(1):25–32

    CAS  Google Scholar 

  36. Tasbandi A, Koushki E, Eshghi H (2017) Opt Quant Electron 49:124–134

    Article  CAS  Google Scholar 

  37. Panwar V, Jain SL (2019) Am J Mater Sci Eng 99:191–201

    Article  CAS  Google Scholar 

  38. Ravichandran S, Nagarajan S, Kokil A, Ponrathnam T, Bouldin RM, Bruno FF, Samuelson L, Kumar J, Nagarajan R (2012) Langmuir 2:13380–13386

    Article  CAS  Google Scholar 

  39. Zou J, Zhao GQ, Teng J, Liu Q, Jiang XY, Jiao FP, Yu JG (2019) Microchem 145:693–702

    Article  CAS  Google Scholar 

  40. Fagadar-Cosma E, Sebarchievici I, Lascu A, Creanga I, Palade A, Birdeanu M, Fagadar-Cosma G (2016) J Alloys Compd 686:896–904

    Article  CAS  Google Scholar 

  41. Zhang GY, Deng SY, Zhang XJ, Shan D (2016) Electrochim Acta 190:64–68

    Article  CAS  Google Scholar 

  42. Balamurugan J, Thanh TD, Karthikeyan G, Kim NH, Lee JH (2017) Biosens Bioelectron 89:970–977

    Article  CAS  PubMed  Google Scholar 

  43. Ran G, Yi WJ, Li Y, Luo HQ, Li NB (2012) Methods 4:2929–2934

    CAS  Google Scholar 

Download references

Funding

This work was supported by two funds: the National Natural Science Foundation of China (21575066) and Science and Technology Research Projects of Henan province (no. 162102310462).

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Authors and Affiliations

  1. Pharmacy College, Henan University of Chinese Medicine, Zhengzhou, 450046, People’s Republic of China

    Yanju Liu, Zhuangzhuang Guo, Lulu Hao, Xinchang Shi & Huaixia Yang

  2. Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, People’s Republic of China

    Shuxun Yan

Authors
  1. Yanju Liu
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  2. Zhuangzhuang Guo
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  3. Lulu Hao
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  4. Xinchang Shi
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  5. Shuxun Yan
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  6. Huaixia Yang
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Correspondence to Shuxun Yan or Huaixia Yang.

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Liu, Y., Guo, Z., Hao, L. et al. Polyethyleneimine-AuNPs-copper protoporphyrin nanocomposite: a novel biosensor for sensitive detection of hydrogen peroxide in human serum. J Solid State Electrochem 23, 2551–2558 (2019). https://doi.org/10.1007/s10008-019-04322-5

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  • DOI: https://doi.org/10.1007/s10008-019-04322-5

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