Skip to main content
SpringerLink
Log in

Simultaneous voltammetric detection of dopamine and uric acid in the presence of high concentration of ascorbic acid using multi-walled carbon nanotubes with methylene blue composite film-modified electrode

  • Original Paper
  • Published:
Journal of Solid State Electrochemistry Aims and scope Submit manuscript

Abstract

An electrochemically functional nanocomposite through the adsorption of methylene blue onto the multi-walled nanotubes (MB-MWNTs) was prepared, and a sensitive voltammetric sensor was fabricated. The modified electrode showed excellent electrocatalytic activity toward dopamine (DA) and uric acid (UA) in 0.1 M phosphate solution medium (pH 3.0). Compared to the bare electrode, the MB-MWNTs film-modified electrode not only remarkably enhanced the anodic peak currents of DA and UA, i.e., shifted the anodic peak potential of DA negatively, but also avoided the overlapping of the anodic peaks of DA and UA. The interference of ascorbic acid (AA) was eliminated. Under the optimized conditions, the peak separation between AA and DA and between DA and UA was 219 and 174 mV, respectively. In the presence of 1.0 mM AA and 10.0 μM UA, the anodic peak current was linear to the concentration of DA in the range of 0.4–10.0 μM with a detection limit of 0.2 μM DA. The anodic peak current of UA was linear to the concentration in the range of 2.0–20.0 and 20.0–200.0 μM with a lowest detection limit of 1.0 μM in the presence of 1.0 mM AA and 1.0 μM DA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13

Similar content being viewed by others

References

  1. Wightman RM, May LJ, Michael AC (1988) Anal Chem 60:769A

    Article  CAS  Google Scholar 

  2. Liu A, Honma I, Zhou HS (2005) Biosens Bioelectron 21:809

    Article  CAS  Google Scholar 

  3. Mo JW, Ogorevc B (2001) Anal Chem 73:1196

    Article  CAS  Google Scholar 

  4. Zen JM, Jou JJ, Ilangovan G (1998) Analyst 123:1345

    Article  CAS  Google Scholar 

  5. Liu AH, Honma I, Zhou HS (2007) Biosens Bioelectron 23:74

    Article  Google Scholar 

  6. Lin XQ, Kang GF, Lu LP (2007) Bioelectrochemistry 70:235

    Article  CAS  Google Scholar 

  7. Kang GF, Lin XQ (2006) Electroanalysis 18:2458

    Article  CAS  Google Scholar 

  8. Zhang YZ, Pan Y, Su S, Zhang LP, Li SP, Shao MW (2007) Electroanalysis 19:1695

    Article  CAS  Google Scholar 

  9. Wang GF, Sun JG, Zhang W, Jiao SF, Fang B (2009) Microchim Acta 16:4357

    Google Scholar 

  10. Zhu SY, Li HJ, Niu WX, Xua GB (2009) Biosens Bioelectron 25:940

    Article  CAS  Google Scholar 

  11. Yao H, Sun YY, Lin XH, Tang YH, Huang LY (2007) Electrochim Acta 52:6165

    Article  CAS  Google Scholar 

  12. Kalimuthu P, John SA (2009) Bioelectrochem 77:13

    Article  CAS  Google Scholar 

  13. Ensafi AA, Khayamian MTT (2009) J Electroanal Chem 633:212

    Article  CAS  Google Scholar 

  14. Zhang R, Jin GD, Chen D, Hu XY (2009) Sens Actuators B 138:174

    Article  Google Scholar 

  15. Li YX, Lin XQ (2006) Sens Actuators B 115:134

    Article  Google Scholar 

  16. Zare HR, Rajabzadeh N, Nasirizadeh N, Ardakani MM (2006) J Electroanal Chem 589:60

    Article  CAS  Google Scholar 

  17. Zheng D, Ye JS, Zhou L, Zhang Y, Yu CZ (2009) J Electroanal Chem 625:82

    Article  CAS  Google Scholar 

  18. Cao XM, Xu YH, Luo LQ, Ding YP, Zhang Y (2010) J Solid State Electrochem 14:829

    Article  CAS  Google Scholar 

  19. Iijima S (1991) Nature 354:56

    Article  CAS  Google Scholar 

  20. Ajayan PM (1999) Chem Rev 99:1787

    Article  CAS  Google Scholar 

  21. Yao H, Li N, Xu S, Xu JZ, Zhu JJ, Chen HY (2005) Biosens Bioelectron 21:372

    Article  CAS  Google Scholar 

  22. Liu CY, Hu JF, Hu JM, Tanga HW (2006) Electroanalysis 18:478

    Article  CAS  Google Scholar 

  23. Xian YZ, Liu F, Xian Y, Zhou YY, Jin LT (2006) Electrochim Acta 51:6527

    Article  CAS  Google Scholar 

  24. Xiao MW, Wang LS, Wu YD, Huang XJ, Dang Z (2008) J Solid State Electrochem 12:1159

    Article  CAS  Google Scholar 

  25. Yan YM, Zhang MN, Gong KP, Su L, Guo ZX, Mao LQ (2005) Chem Mater 17:3463

    Google Scholar 

  26. Yogeswaran U, Chen SM (2008) Sens Actuators B 130:739

    Article  Google Scholar 

  27. Li Q, Zhang J, Yan H, He M, Liu Z (2004) Carbon 42:287

    Article  CAS  Google Scholar 

  28. Zhang J, Lee JK, Wu Y, Murray RW (2003) Nano Lett 3:403

    Article  CAS  Google Scholar 

  29. Zhang M, Gong K, Zhang H, Mao L (2005) Biosens Bioelectron 20:1270

    Article  CAS  Google Scholar 

  30. Chen RJ, Zhang Y, Wang D, Dai H (2001) J Am Chem Soc 123:3838

    Article  CAS  Google Scholar 

  31. Sagara T, Niki K (1993) Langmuir 9:831

    Article  CAS  Google Scholar 

  32. Mozhgan KM, Aboozar T (2010) Talanta 80:1657

    Article  Google Scholar 

  33. Yogeswaran U, Chen SM (2007) Electrochim Acta 52:5985

    Article  CAS  Google Scholar 

  34. Mohammad MA, Hadi B, Bahram G, Hossein N, Maryam N (2009) Bioelectrochemistry 75:1

    Article  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge the support of this work by the National Natural Science Foundation of China (no. 20472076) and the Natural Science Foundation of Henan Province in China (no. 0512001400).

Author information

Authors and Affiliations

  1. Department of Chemistry, Zhengzhou University, Zhengzhou, 450001, People’s Republic of China

    Suling Yang, Ran Yang, Miaomiao Xia & Lingbo Qu

  2. College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455002, People’s Republic of China

    Gang Li & Lingbo Qu

  3. Chemistry and Chemical Engineering School, Henan University of Technology, Zhengzhou, 450001, People’s Republic of China

    Lingbo Qu

Authors
  1. Suling Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ran Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Miaomiao Xia
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lingbo Qu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lingbo Qu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, S., Li, G., Yang, R. et al. Simultaneous voltammetric detection of dopamine and uric acid in the presence of high concentration of ascorbic acid using multi-walled carbon nanotubes with methylene blue composite film-modified electrode. J Solid State Electrochem 15, 1909–1918 (2011). https://doi.org/10.1007/s10008-010-1210-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10008-010-1210-x

Keywords

Search

Navigation