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Electrocatalytic oxidation of the antiviral drug acyclovir on a copper nanoparticles-modified carbon paste electrode

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Abstract

The electrocatalytic oxidation of acyclovir (Zovirax) on two different copper-based electrodes: copper microparticles- and copper nanoparticles-modified carbon paste electrodes (denoted as micro-CPE and nano-CPE, respectively) was voltammetrically investigated. In the voltammogram recorded using micro-CPE, a single anodic oxidation peak appeared, while nano-CPE resulted in two overlapped anodic peaks. The anodic currents were related to the electrocatalytic oxidation of acyclovir via the electrogenerated active species of Cu(III) with an EC’ mechanism. Acyclovir was oxidized with higher rates at low potentials on nano-CPE compared to micro-CPE. This was related to the nanosize effect of copper nanoparticles. The constants of the electrocatalytic oxidation process and the diffusion coefficient of acyclovir were reported. A sensitive and time-saving determination procedure was developed for the analysis of acyclovir and the corresponding analytical parameters were reported. The proposed amperometric method was applied to the analysis of commercial pharmaceutical products (tablets and topical cream) and the results were in good agreement with the declared values.

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Acknowledgments

The financial support of the Iran National Science Foundation (INSF) and the Research Council of University of Tehran are gratefully acknowledged.

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Authors and Affiliations

  1. Institute of Biochemistry and Biophysics, University of Tehran, P. O. Box: 13145-1384, Tehran, Iran

    H. Heli & A. A. Moosavi-Movahedi

  2. Department of Chemistry, Razi University, Kermanshah, Iran

    H. Heli

  3. Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran

    M. Zarghan & A. Jabbari

  4. Sobhan Chemotherapeutics Co., Tehran, Iran

    A. Parsaei

  5. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

    A. A. Moosavi-Movahedi

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  1. H. Heli
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  2. M. Zarghan
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  5. A. A. Moosavi-Movahedi
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Correspondence to H. Heli.

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Heli, H., Zarghan, M., Jabbari, A. et al. Electrocatalytic oxidation of the antiviral drug acyclovir on a copper nanoparticles-modified carbon paste electrode. J Solid State Electrochem 14, 787–795 (2010). https://doi.org/10.1007/s10008-009-0846-x

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  • DOI: https://doi.org/10.1007/s10008-009-0846-x

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