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Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial

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Abstract

Objective

This study evaluated the efficacy of Valeriana officinalis L. and Passiflora incarnata L. to control anxiety, surgical discomfort, and changes in vital signs of patients undergoing extraction of two unilateral third molars.

Materials and methods

This study is a randomized, triple-blinded clinical trial. Fifty-four patients were allocated into three groups (Valeriana officinalis L., Passiflora incarnata L., and placebo). Anxiety levels were assessed using the State-Trace Anxiety Inventory (STAI) index, surgical discomfort using the QCirDental, and through the measurement of vital signs. The surgical times evaluated were before (T0), during (T1), and after surgery (T2).

Results

There was evidence that both Valeriana officinalis L. and Passiflora incarnata L., reduced STAY-S scores between T0 and T2 (p < .05), unlike placebo (p = .129). There was no change in surgical discomfort in all groups over time, and vital signs presented variable results.

Conclusion

Phytotherapy drugs showed a reduction in anxiety state compared to the placebo group during third molar extraction procedure. 

Clinical trial registration

klRBR-6kcxvrc, March 10, 2022.

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Data availability

No datasets were generated or analysed during the current study.

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Acknowledgements

We would like to thank the Pharmacy School of UFPR for their contribution.

Funding

The following work was funded by CAPES program number: 40001016065P8.

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Authors and Affiliations

  1. Department of Stomatology, Federal University of Parana, 632 Prefeito Lothario Meissner Avenue, Curitiba, PR, 80210-170, Brazil

    Amalia Celsy Abregu Velasquez, Mayumi Tsuji, Lidiana dos Santos Cordeiro & Maria Fernanda Pivetta Petinati

  2. Department of Stomatology, Federal University of Parana, 632 Prefeito Lothario Meissner Avenue, Curitiba, PR, 80210-170, Brazil

    Nelson Luis Barbosa Rebellato, Aline Monise Sebastiani, Delson João da Costa & Rafaela Scariot

Authors
  1. Amalia Celsy Abregu Velasquez
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  2. Mayumi Tsuji
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  3. Lidiana dos Santos Cordeiro
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  4. Maria Fernanda Pivetta Petinati
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  5. Nelson Luis Barbosa Rebellato
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  6. Aline Monise Sebastiani
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  7. Delson João da Costa
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  8. Rafaela Scariot
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Contributions

All authors contributed to the study's conception and design. Material preparation, data collection and analysis were performed by Amalia Celsy Abregu Velasquez, Mayumi Tsuji, Lidiana dos Santos Cordeiro, Maria Fernanda Pivetta Petinati and Rafaela Scariot. The first draft of the manuscript was written by Amalia Celsy Abregu Velasquez and all authors, including Nelson Luis Barbosa Rebellato, Aline Monise Sebastiani and Delson João da Costa, participated in the Review & Editing, Formal analysis, validation and commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Rafaela Scariot.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Research Ethics Committee of the University Federal of Paraná (protocol #39827620.4.0000.0102 and # 4.511.8201) on, January 27, 2021. It was also approved in the REBEC platform (No. RBR-6KCXVRC).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Velasquez, A.C.A., Tsuji, M., dos Santos Cordeiro, L. et al. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial. Oral Maxillofac Surg (2024). https://doi.org/10.1007/s10006-024-01259-6

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