Skip to main content
SpringerLink
Log in

Epoxy resin bioactive dental implant capped with hydroxyapatite and curcumin nanoparticles: a novel approach

  • Research
  • Published:
Oral and Maxillofacial Surgery Aims and scope Submit manuscript

Abstract

Objective

In this study, the developed bioactive dental implant (BDI) from epoxy resin (ER), hydroxyapatite (HA), and curcumin nanoparticles (CUNPs).

Materials and methods

The prepared BDI were characterized using their physicochemical, mechanical, antimicrobial, bioactive, and biocompatibility study. The scanning electron microscopy (SEM) morphology of the BDI was observed HA mineralized crystal layer after being immersed in the stimulated body fluids (SBF) solution.

Results

The mechanical properties of the BDI exhibited tensile strength (250.61 ± 0.43 MPa), elongation at break (215.66 ± 0.87%), flexural modulus (03.90 ± 0.12 GPa), water absorption (05.68 ± 0.15%), and water desorption (06.42 ± 0.14%). The antimicrobial activity of BDI was observed in excellent zone of inhibition against the gram-negative (15.33 ± 0.04%) and gram- positive (15.98 ± 0.07%) bacteria. The biocompatibility study of BDI on osteoblasts cell line (MG-63) was analyzed using MTT (3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results were observed 85% viable cells present in the BDI compared to the control (only ER) samples.

Conclusions

Based on the research outcome, the BDI could be used for biomaterials application, particularly tooth dental implantation.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Data availability

No datasets were generated or analysed during the current study.

References

  1. Atsuomi S, Satoru Y, Keiji T (2022) Network formation and physical properties of Epoxy resins for future practical applications. J Am Chem Soc 2:1522–1542

    Google Scholar 

  2. Pratap B, Gupta RK, Bhardwaj B, Nag M (2019) Resin based restorative dental materials: characteristics and future perspectives. Japan Dent Sci Rev 55:126–138

    Article  Google Scholar 

  3. Viguie G, Malquarti G, Vincent B, Bourgeois D (1994) Epoxy/carbon composite resins in dentistry: mechanical properties related to fiber reinforcement. J Prosthet Dent 72:245–249

    Article  CAS  PubMed  Google Scholar 

  4. Badami V, Ahuja B (2014) Biosmart materials: breaking new ground in dentistry. Sci World J 98:6912

    Google Scholar 

  5. Sodagar A, Bahador A, Pourhajibagher M, Ahmadi B, Baghaeian P (2016) Effect of Addition of Curcumin nanoparticles on Antimicrobial Property and Shear Bond Strength of Orthodontic Composite to bovine enamel. J Dent (Tehran) 13:373–382

    PubMed  Google Scholar 

  6. Moraes G, Zambom C, Siqueira WL (2021) Nanoparticles in Dentistry: a Comprehensive Review. Pharmaceuticals (Basel) 14:752

    Article  CAS  PubMed  Google Scholar 

  7. Hamilton AE, Gilbert RJ (2023) Curcumin Release from Biomaterials for enhanced tissue regeneration following Injury or Disease. Bioeng 10:262

    CAS  Google Scholar 

  8. Yallapu MM, Nagesh PK, Jaggi M, Chauhan SC (2015) Therapeutic applications of Curcumin Nanoformulations. AAPS Pharm Sci 17:1341–1356

    CAS  Google Scholar 

  9. Monika N, Shaveta S (2013) Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med 4:3–7

    Article  Google Scholar 

  10. Meredith N (1998) Assessment of implant stability as a prognostic determinant. Int J Prosthodont 11:491–501

    CAS  PubMed  Google Scholar 

  11. Andreotti AM, Goiato MC, Nobrega AS, Freitas da Silva EV, Filho HG, Pellizzer EP, Micheline Dos Santos D (2017) Relationship between Implant Stability measurements obtained by two different devices: a systematic review. J Periodontol 88:281–288

    Article  PubMed  Google Scholar 

  12. Pawar HA, Gavasane AJ, Choudhary PD (2018) A novel and simple Approach for extraction and isolation of Curcuminoids from Turmeric rhizomes. Adv Recycl Waste Manag 6:2

    Google Scholar 

  13. Sandhuli SH, Shashiprabha PD, Asiri ND, Gamini Rajapakse RM (2021) Synthesis of curcumin nanoparticles from raw turmeric rhizome. ACS Omega 6:8246–8252

    Article  Google Scholar 

  14. De Rosa IM, Santulli C, Sarasini F (2010) Mechanical and thermal characterization of epoxy composites reinforced with random and quasi-unidirectional untreated Phormium tenax leaf fibers. Mater Des 31:2397–2405

    Article  Google Scholar 

  15. Reinhart TJ (1990) Engineered materials handbook composites. In: McCarvill William T, Scardino Weldon M, editors. Wet lay-up resins and adhesives specifications, vol. 1. Ohio: ASM International 132–4, 689–701

  16. Basniwal RK, Buttar HS, Jain VK, Jain N (2011) Curcumin nanoparticles: Preparation, characterization, and Antimicrobial Study. J Agri Food Chem 59:2056–2061

    Article  Google Scholar 

  17. Ferraz MP (2004) Hydroxyapatite nanoparticles: a review of preparation methodology. J Appl Biomater Biomech 2:74–80

    CAS  PubMed  Google Scholar 

  18. Albasarah S, Al Abdulghani H, Alaseef N, Al-Qarni FD, Akhtar S, Khan SQ, Ateeq IS, Gad MM (2021) Impact of ZrO2 nanoparticles addition on flexural properties of denture base resin with different thickness. J Adv Prosthodont 13:226–236

    Article  PubMed Central  PubMed  Google Scholar 

  19. Darwish MSA, Mostafa MH, Al-Harbi LM (2022) Polymeric nanocomposites for Environmental and Industrial Applications. Int J Mol Sci 23:1023

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Fadilah NIM, Isa ILM, Zaman WSWK, Tabata Y, Fauzi MP (2022) The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: a systematic review. Polym 14:476

    Article  CAS  Google Scholar 

  21. Zhang Z, Lu W, Tony KFC, Zigui C, Margaret IP, Paul KSC, Joseph JYS, Li Z (2022) Micro-/Nanorobots in antimicrobial applications: recent progress, challenges, and opportunities. Adv Healthc Mater 11:2101991

    Article  CAS  Google Scholar 

  22. Pinto RM, Soares FA, Reis S, Nunes C, Van Dijck P (2020) Innovative strategies toward the Disassembly of the EPS Matrix in Bacterial Biofilms. Front Microbiol 11:952

    Article  PubMed Central  PubMed  Google Scholar 

  23. Jerri Al-Bakhsh BA, Shafiei F, Pour Hajibagher M, Shekofteh K, Hashemian A, Behroozi Bakhsh M (2019) The antibacterial activity of an epoxy resin-based dental sealercontaining bioactive glass, hydroxyapatite, and fluorohydroxyapatite nanoparticles against enterococcus faecalis and streptococcus mitis. Nanomed J. ; 6(3)

  24. El-Nashar DE, Rozik NN, Soliman AM, Helaly F (2016) Study the release kinetics of curcumin released from PVA/Curcumin composites and its evaluation towards hepatocarcinoma. J Appl Pharm Sci 6:67–72

    Article  CAS  Google Scholar 

  25. Senthil R, Çakır S (2023) Nano apatite growth on demineralized bone matrix capped with curcumin and silver nanoparticles: Dental implant mechanical stability and optimal cell growth analysis. J Oral Biosci. https://doi.org/10.1016/j.job.2023.12.004

    Article  PubMed  Google Scholar 

  26. Senthil R, Sinem Ç, Batıkan Kavukcu S, Wilson Aruni A (2022) Fabrication of cylindrical bone graft substitute supported by reduced graphene-oxide and nanocurcumin to promotes the bone tissue development. Mater Lett 322:132475

    Article  CAS  Google Scholar 

  27. Mondschein RJ, Kanitkar A, Williams CB, Verbridge SS, Long TE (2017) Polymer structure-property requirements for stereolithographic 3D printing of soft tissue engineering scaffolds. Biomater 140:170–188

    Article  CAS  Google Scholar 

  28. Leonhardt S, Klare M, Scheer M, Fischer T, Cordes B, Eblenkamp M (2016) Biocompatibility of photopolymers for additive manufacturing. Curr Dir Biomed Eng 2:113–116

    Article  Google Scholar 

  29. Frasheri I, Aumer K, Keßler A, Miosge N, Folwaczny M (2022) Effects of resin materials dedicated for additive manufacturing of temporary dental restorations on human gingival keratinocytes. J Esthet Restor Dent 34:1105–1112

    Article  PubMed  Google Scholar 

  30. Baqain ZH, Moqbel WY, Sawair FA (2012) Early dental implant failure: risk factors. Br J Oral Maxillofac Surg 50:239–243

    Article  PubMed  Google Scholar 

  31. Le Guéhennec L, Soueidan A, Layrolle P, Amouriq Y (2007) Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater 23:844–854

    Article  Google Scholar 

Download references

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Dental College and Hospitals, Saveetha University, Chennai, 600 077, Tamilnadu, India

    Rethinam Senthil

Authors
  1. Rethinam Senthil
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Rethinam Senthil – Methodology, Characterization, Formal analysis, writing the original draft, and revision.

Corresponding author

Correspondence to Rethinam Senthil.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed.

by author.

Clinical trial number in the manuscript

Not Applicable.

Consent to participate

Not Applicable.

Consent to publish

Not Applicable.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Senthil, R. Epoxy resin bioactive dental implant capped with hydroxyapatite and curcumin nanoparticles: a novel approach. Oral Maxillofac Surg (2024). https://doi.org/10.1007/s10006-024-01252-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10006-024-01252-z

Keywords

Search

Navigation