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Use of ozone therapy in Implant Dentistry: a systematic review

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Abstract

Purpose

Ozone is a potent antioxidant agent which presents an important antimicrobial action and many other biological effects. Although ozone therapy has been widely described and summarized in several other Dentistry areas recently, the studies concerning Dental Implantology have not been systematically compiled and evaluated. Thus, the present study aimed to evaluate the effectiveness of ozone therapy in dental implant procedures.

Methods

MEDLINE (via PUBMED), Cochrane Central Register of Controlled Trials (CENTRAL), and OpenGrey databases were searched (up to, and including, January 23, 2023) for studies in the English language. In addition, the reference lists of the articles were manually examined. Only interventional studies (controlled clinical trials, randomized or not) were considered eligible for inclusion. The risk of bias in each included study was assessed using the Cochrane tool for assessing risk of bias in randomized trials – version 2.

Results

71 potentially eligible records were retrieved but only 5 articles were evaluated and considered eligible for inclusion. Among the studies, 2 addressed clinical situations related to implant insertion, and 3 involved pathological conditions affecting implants in function. Furthermore, only one randomized clinical trial was categorized as low risk of bias.

Conclusion

The adjuvant use of ozone therapy may positively affect some outcomes in Implant Dentistry, both in treating pathological conditions and conducting rehabilitation (implant installation, secondary implant stability). However, as most studies have a high risk of bias and high heterogeneity, a definitive conclusion cannot be drawn.

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Author information

Authors and Affiliations

  1. Specialization Course in Oral Implantology, Faculdade CTA, São Paulo, SP, Brazil

    Cristhye Jane Randi & Clovis Marinho Carvalho Heiderich

  2. Graduate Dentistry Program, Ibirapuera University, São Paulo, SP, Brazil

    Rafael Verardi Serrano

  3. School of Dentistry, Department of Orthodontics and Pediatric Dentistry, University of São Paulo, São Paulo, SP, Brazil

    Susana Morimoto

  4. Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, SP, Brazil

    Luís Otávio Carvalho de Moraes

  5. Graduate Program in Implantology, School of Dentistry, University of Santo Amaro, São Paulo, SP, Brazil

    Luana Campos

  6. Department of Pathology, Federal University of São Paulo, São Paulo, SP, Brazil

    Luiz Felipe Palma

Authors
  1. Cristhye Jane Randi
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  2. Clovis Marinho Carvalho Heiderich
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  3. Rafael Verardi Serrano
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  4. Susana Morimoto
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  5. Luís Otávio Carvalho de Moraes
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  6. Luana Campos
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  7. Luiz Felipe Palma
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Contributions

Cristhye Jane Randi—Conceptualization, Methodology, Data Analysis, Writing—Original draft preparation.

Clovis Marinho Carvalho Heiderich—Conceptualization, Methodology, Data Analysis, Writing—Original draft preparation.

Rafael Verardi Serrano—Conceptualization, Methodology, Writing—Reviewing and Editing.

Susana Morimoto—Conceptualization, Methodology, Writing—Reviewing and Editing.

Luís Otávio Carvalho Moraes—Conceptualization, Methodology, Writing—Reviewing and Editing.

Luana Campos—Conceptualization, Methodology, Writing—Reviewing and Editing.

Luiz Felipe Palma—Conceptualization, Methodology, Data Analysis, Writing—Original draft preparation.

Corresponding author

Correspondence to Luiz Felipe Palma.

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Randi, C.J., Heiderich, C.M.C., Serrano, R.V. et al. Use of ozone therapy in Implant Dentistry: a systematic review. Oral Maxillofac Surg 28, 39–49 (2024). https://doi.org/10.1007/s10006-023-01149-3

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  • DOI: https://doi.org/10.1007/s10006-023-01149-3

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