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Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis

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Abstract

The localized juvenile spongiotic gingival hyperplasia (LJSGH) mainly affects the maxillary vestibular attached gingiva of juvenile patients, without sex predilection. Similar lesions involving extragingival sites have not been reported to date. Here, we report 2 cases of extragingival soft tissue lesions with similar clinicopathological features to those reported in LJSGH and 12 cases of intraoral reactive soft tissue lesions microscopically showing LJSGH-like focal areas. The 2 cases were adult patients, affecting the maxillary alveolar ridge (55-year-old female) and hard palate (78-year-old male), which were diagnosed as “spongiotic hyperplasia of the oral mucosa.” The 12 intraoral reactive soft tissue lesions (6 men and 6 women; mean age, 49.5 years) were diagnosed as inflammatory fibrous hyperplasia (n = 6), peripheral ossifying fibroma (n = 3), and pyogenic granuloma (n = 3), each of them presenting LJSGH-like focal areas. By immunohistochemistry, the spongiotic hyperplasia areas showed positivity for CK19, CK14, CK34βE12, and CAM5.2 (weak/focal), while CK4 was negative. Considering the anatomical locations (extragingival) of these 2 cases, the term “spongiotic hyperplasia of the oral mucosa” is suggested. Moreover, LJSGH-like focal areas can be detected when microscopically assessing common intraoral reactive soft tissue lesions.

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Funding

Heitor Albergoni Silveira (2018/12734–2), Luciana Yamamoto Almeida (2016/02713–2), Andreia Bufalino (2017/01438–0), and Jorge Esquiche León (2016/11419–0) have received research grants from the State of São Paulo Research Foundation (FAPESP).

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Authors and Affiliations

  1. Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil

    Heitor Albergoni Silveira, Evânio Vilela Silva & Andreia Bufalino

  2. Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil

    Heitor Albergoni Silveira, Evânio Vilela Silva & Jorge Esquiche León

  3. School of Dentistry, National Autonomous University of Mexico, Toluca de Lerdo, Mexico

    Victor Hugo Toral-Rizo & Edith Lara-Carrillo

  4. Universidade Vale Do Rio Verde (UninCor), Três Corações, MG, Brazil

    Matheus Henrique Lopes Dominguete

  5. Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil

    Alfredo Ribeiro-Silva

  6. Department of Diagnosis and Surgery, Univ Estadual Paulista (UNESP), Rua Humaitá, 1680, CEP 14801-903, Araraquara, São Paulo, Brazil

    Luciana Yamamoto Almeida

Authors
  1. Heitor Albergoni Silveira
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  2. Victor Hugo Toral-Rizo
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  3. Edith Lara-Carrillo
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  4. Matheus Henrique Lopes Dominguete
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  5. Evânio Vilela Silva
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  6. Alfredo Ribeiro-Silva
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  7. Andreia Bufalino
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  8. Luciana Yamamoto Almeida
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  9. Jorge Esquiche León
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Contributions

Study concept and design: Silveira HA, Toral-Rizo VH, Dominguete MHL, Bufalino A, Silva EV, and León JE. Analysis and interpretation of data: Silveira HA, Toral-Rizo VH, Lara-Carrillo E, Dominguete MHL, Ribeiro-Silva A, Almeida LY, and León JE. Critical review of the manuscript: Silveira HA, Toral-Rizo VH, Lara-Carrillo E, Dominguete MHL, Ribeiro-Silva A, Silva EV, Bufalino A, Almeida LY, and León JE.

Corresponding author

Correspondence to Jorge Esquiche León.

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Silveira, H.A., Toral-Rizo, V.H., Lara-Carrillo, E. et al. Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis. Oral Maxillofac Surg 26, 333–337 (2022). https://doi.org/10.1007/s10006-021-00996-2

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  • DOI: https://doi.org/10.1007/s10006-021-00996-2

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