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Effects of boric acid on bone formation after maxillary sinus floor augmentation in rabbits

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Abstract

Purpose

Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA).

Materials and methods

Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3.

Results

The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05).

Conclusion

Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.

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Funding

This study was financially supported by The Scientific and Technological Research Council of Turkey—Health Sciences Research Group (TUBITAK-SBAG; project number 113S258).

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Celebi University, Aydinlikevler District Cemil Meric St. 6780 St., 35640, Cigli, Izmir, Turkey

    Murat Ulu & Hüseyin Akçay

  2. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem University, 34093, Istanbul, Turkey

    Nükhet Kütük & Alper Alkan

  3. Oral and maxillofacial surgeon, private practitioner, 35640, Izmir, Turkey

    Muhammet Furkan Cıcık

  4. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, 38039, Kayseri, Turkey

    Suheyb Bilge

  5. Department of Histology and Embryology, Faculty of Medicine, T.C. Kütahya Sağlık Bilimleri University, 43100, Kütahya, Turkey

    Suna Saygılı

  6. Department of Histology and Embryology, Faculty of Medicine, Manisa Celal Bayar University, 45030, Manisa, Turkey

    Mehmet İbrahim Tuğlu

Authors
  1. Murat Ulu
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  2. Nükhet Kütük
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  3. Muhammet Furkan Cıcık
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  4. Suheyb Bilge
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  5. Hüseyin Akçay
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  6. Suna Saygılı
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  7. Mehmet İbrahim Tuğlu
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  8. Alper Alkan
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Corresponding authors

Correspondence to Murat Ulu or Hüseyin Akçay.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All applicable international, national, and institutional guidelines for the care and use of animals were followed. The protocol for this study was approved by Erciyes University Medical School Animal Care and Use Committee.

Informed consent

This study does not contain any experiment with human participants.

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Ulu, M., Kütük, N., Cıcık, M.F. et al. Effects of boric acid on bone formation after maxillary sinus floor augmentation in rabbits. Oral Maxillofac Surg 22, 443–450 (2018). https://doi.org/10.1007/s10006-018-0729-3

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  • DOI: https://doi.org/10.1007/s10006-018-0729-3

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