Advertisement

Oral and Maxillofacial Surgery

, Volume 17, Issue 3, pp 161–164 | Cite as

Papillary cystadenoma of the lower lip exhibiting ciliated pseudostratified columnar epithelium: report of a bizarre case and review of the literature

  • Panagiotis StathopoulosEmail author
  • Eleni Gagari
Review Article

Abstract

Background

Salivary gland tumors are uncommon and constitute 2–6.5 % of all head and neck neoplasms. Tumors of minor salivary gland origin account for less than 25 % of all salivary gland neoplasms. Papillary cystadenoma of salivary glands is a rare benign epithelial neoplasm characterized by multicystic growth in which the epithelium exhibits adenomatous proliferation. Papillary cystadenoma of minor salivary glands most frequently involves the lip, buccal mucosa, and palate. This tumor typically presents as a slow-growing, painless mass, usually with diameter of less than 1 cm and clinical resemblance to a mucocele. Although most papillary cystadenomas are predominantly of one cell type, a regional variability may be present.

Case Report

We present a case of papillary cystadenoma of the minor salivary glands in a 58-year-old patient exhibiting an upper respiratory tract epithelium, a profoundly atypical benign tumor.

Discussion

This type of minor salivary gland tumor epithelium in the lower lip may be the result of a metaplastic process or simply another neoplastic manifestation of papillary cystadenoma. As far as the differential diagnosis of this entity is concerned, it is important to distinguish it from papillary cystadenoma lymphomatosum (Warthin's tumor), low-grade mucoepidermoid carcinoma, the papillary-cystic variant of acinic cell carcinoma, and cystadenocarcinoma Recognition of this lesion is important for the clinician since the differential diagnosis includes lesions with similar clinical appearance and infiltrative behavior.

Keywords

Papillary cystadenoma Minor salivary gland tumors Ciliated pseudostratified columnar epithelium 

Notes

Conflict of interest

The authors of this paper declare that they have no conflict of interest.

References

  1. 1.
    Auclair PL, Ellis GL, Gnepp DR, Wenig BM, Janney CG (1991) Salivary gland neoplasms: general considerations. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical Pathology of the Salivary Glands. W.B. Saunders Co, Philadelphia, pp 135–164Google Scholar
  2. 2.
    Alexis JB, Dembrow V (1995) Papillary cystadenoma of a minor salivary gland. J Oral Maxillofac Surg 53(1):70–72PubMedCrossRefGoogle Scholar
  3. 3.
    Skalova A, Michal M (2005) Cystadenoma. In: Barnes L, Eveson JW, Reichart P, et al.,eds. World Health Organization Classification of Tumors of Tumors: pathology and genetics of tumors of the head and neck. Lyon: IARC pp 273-274Google Scholar
  4. 4.
    Auclair PL, Ellis GL, Gnepp DR (1991) Other benign epithelial neoplasms. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. Saunders, Philadelphia, pp 252–268Google Scholar
  5. 5.
    Ellis GL, Auclair PL (1996) Cystadenoma. In: Atlas of tumor pathology: tumors of the salivary glands. 3rd series, fascicle 17. Washington DC: Armed Forces Institute of Pathology pp 115-120Google Scholar
  6. 6.
    Ribeiro DA, Costa MR, de Assis GF (2004) Papillary cystadenoma of the minor salivary gland of the lower lip. Dermatol Online J 10(1):14PubMedGoogle Scholar
  7. 7.
    Mahler V, Schell H (1999) Papillary cystadenoma: a rare tumor of the minor salivary glands. Eur J Dermatol 9(5):387–389PubMedGoogle Scholar
  8. 8.
    Lim CS, Ngu I, Collins AP, McKellar GM (2008) Papillary cystadenoma of a minor salivary gland: report of a case involving cytological analysis and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(1):e28–e33PubMedCrossRefGoogle Scholar
  9. 9.
    Eveson JW, Nagao T (2009) Cystadenoma. In: Diseases of the salivary glands. In: Barnes L eds: Surgical pathology of the head and neck 3rd ed. New York: Informa Healthcare pp 538-540Google Scholar
  10. 10.
    Waldron CA, El-Mofty SK, Gnepp DR (1988) Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg 66:323–333PubMedCrossRefGoogle Scholar
  11. 11.
    Callego L, Junquera L, Fresno MF, De Vicente HC (2008) Papillary cystadenoma and cystadenocarcinoma of salivary glands: two unusual entities. Med Oral Pathol Oral Cir Bucal 13(7):460–463Google Scholar
  12. 12.
    Matsuzaka K, Kokubu E, Takeda E et al (2003) Papillary cystadenoma arising from the upper lip: a case report. Bull Tokyo dent 44:213–216CrossRefGoogle Scholar
  13. 13.
    Tsurumi K, Kamiya H, Yokoi M, Kameyama Y (2003) Papillary oncocytic cystadenoma of palatal minor salivary gland: a case report. J Oral Maxillofac Surg 61:631–633PubMedCrossRefGoogle Scholar
  14. 14.
    Seifert G (1991) Histologic typing of salivary gland tumors (2nd ed). New York, NY, Springer pp 16-17Google Scholar
  15. 15.
    Chaudhry AP, Vickers RA, Gorlin RJ (1961) Intraoral minor salivary gland tumors: an analysis of 1414 cases. Oral Surg Oral Med Oral Pathol 14:1194–1126PubMedCrossRefGoogle Scholar
  16. 16.
    Guccion JG, Redman RS, Calhoun NR et al (1997) Papillary cystadenoma of the palate: a case report and ultrastructural study. J Oral Maxillofac Surg 55:759–764PubMedCrossRefGoogle Scholar
  17. 17.
    Toida M, Shimokawa K, Makita H et al (2005) Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34:528–532PubMedCrossRefGoogle Scholar
  18. 18.
    Cohen MA, Batsakis JG (1968) Oncocytic tumors (oncocytomas) of minor salivary glands. Arc Otolaryngol 88:71–73CrossRefGoogle Scholar
  19. 19.
    Zhou QW, Gao JP, Wu B, Zhou SS (2003) Papillary cystadenoma of the epididymis accompanied by testicular atrophy: a case report. Zhonghua Nan Ke Xue 9:389–390PubMedGoogle Scholar
  20. 20.
    Fatum M, Rojansky N, Shushan A (2001) Papillary serous cystadeno-fibroma of the ovary—is it really so rare? Int J Gynaecol Obstet 75:85–86PubMedCrossRefGoogle Scholar
  21. 21.
    Davidov MI, Ponomareva TB, Liadov AA (2003) Multiple bilateral papillary cystadenoma of the kidney. Urologiia 3:60–61PubMedGoogle Scholar
  22. 22.
    Masi JD, Hoang K, Sawyer R (1986) Sialadenoma papilliferum of the adenoids in a 2-year-old child. Arch Pathol Lab Med 110:558PubMedGoogle Scholar
  23. 23.
    Warnock GR (1991) Papillary cystadenoma lymphomatosum (Warthin's tumor). In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. W.B. Saunders Co, Philadelphia, pp 187–201Google Scholar
  24. 24.
    Gorlin RJ (1957) Potentialities of oral epithelium manifest by mandibular dentigerous cysts. Oral Surg Oral Med Oral Pathol 10(3):271–284PubMedCrossRefGoogle Scholar
  25. 25.
    Waldron CA (1995) Odontogenic cysts and tumors. In: Neville B, Damm D, Allen C, Bouquot J (eds) Oral and maxillofacial pathology. WB Saunders, Philadelphia, pp 493–540Google Scholar
  26. 26.
    Boffano P, Zavattero E, Campisi P, Gallesio C (2009) Surgical treatment of an oral cyst with respiratory epithelium. J Craniofac Surg 20(4):1275–1277PubMedCrossRefGoogle Scholar
  27. 27.
    Cohen MB, Liung BM, Boles R (1988) Salivary gland tumors. Fine needle aspiration versus frozen section diagnosis. Arch Otolaryngol Head Neck Surg 112:867–869CrossRefGoogle Scholar
  28. 28.
    Orell SR, Nette WJ (1988) Fine needle aspiration of salivary gland tumors. Problems and pitfalls. Pathology 20:332–337PubMedCrossRefGoogle Scholar
  29. 29.
    Adibfar A, Mintz SM (1994) Papillary cystadenoma lymphomatosum of the upper lip: report of case. J Oral Maxillofac Surg 52:183–185PubMedCrossRefGoogle Scholar
  30. 30.
    Foss RD, Ellis GL, Auclair PL (1996) Salivary gland cystadenocarcinomas. A clinicopathologic study of 57 cases. Am J Surg Pathol 20(12):1440–1447PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial SurgerySouthern General Hospital of GlasgowPollokshieldsUK
  2. 2.Oral Medicine Clinic, A. Syggros Hospital of Dermatologic and Venereal Diseases, Department of Dermatology, School of MedicineUniversity of AthensAthensGreece

Personalised recommendations