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Three-dimensional organization of actin cytoskeleton and podosomal contact structures in neoplastic cells in vitro

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Experimental Biology Online

Abstract

In spontaneously metastasizing rat RPS sarcoma cells, a 3D structure of oblique F-actin cables was observed which was associated with active cell migration in vitro. This led us to further comparative investigations of several other neoplastic and normal cell populations in vitro for F-actin structures using confocal laser scanning microscopy (CLSM). Various forms of F-actin cytoskeleton were observed and the incidence of podosome-related contact structures appeared to be associated with malignancy, interpreted as metastatic capacity.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Pavel Vesely, Luboslava Pavlikova, Jiri Plachy, Katerina Trejbalova, Jiri Hejnar & Eva Matouskova

  2. Cinematic Cell Research Group, Biocentre, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

    Jürgen Bereiter-Hahn

Authors
  1. Pavel Vesely
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  2. Luboslava Pavlikova
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  3. Jiri Plachy
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  4. Katerina Trejbalova
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  5. Jiri Hejnar
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  6. Eva Matouskova
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  7. Jürgen Bereiter-Hahn
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Correspondence to Pavel Vesely.

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Vesely, P., Pavlikova, L., Plachy, J. et al. Three-dimensional organization of actin cytoskeleton and podosomal contact structures in neoplastic cells in vitro. EBO 2, 1–74 (1997). https://doi.org/10.1007/s00898-997-0006-7

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  • DOI: https://doi.org/10.1007/s00898-997-0006-7

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