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Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme

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Abstract

The use of proteinases as targets to develop novel chemotherapies against Leishmania spp. infections is a very promising strategy. Based on a previous study by Goyal et al. [J Mol Model (2014) 20:2099], we discuss herein the idea that only a combined treatment with distinct proteinase inhibitors would be an effective antileishmanial therapy.

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Authors and Affiliations

  1. Fundação Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro, CEP 21040-360, Brazil

    Carlos Roberto Alves, Bernardo Acácio Santini Pereira, Mariana Silva-Almeida & Franklin Souza da Silva

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  1. Carlos Roberto Alves
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  2. Bernardo Acácio Santini Pereira
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  3. Mariana Silva-Almeida
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  4. Franklin Souza da Silva
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Correspondence to Carlos Roberto Alves.

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Alves, C.R., Pereira, B.A.S., Silva-Almeida, M. et al. Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme. J Mol Model 20, 2465 (2014). https://doi.org/10.1007/s00894-014-2465-4

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  • DOI: https://doi.org/10.1007/s00894-014-2465-4

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