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Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia

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Abstract

Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized LDL-R knockout; sedentary ovariectomized LDL-R knockout; and trained ovariectomized LDL-R knockout. Physical exercise practice promoted improvement in biometric and biochemical parameters analyzed, with reduction of visceral adipose tissue and VLDL, triglycerides, total cholesterol, and blood glucose levels. In addition, physical exercise practice altered the morphology of pancreatic islets and improved their response to the effects of menopause. Thus, physical exercise practice was fundamental to minimize the effects of dyslipidemia associated with ovariectomy in the pancreatic tissue of LDL-R knockout animals, contributing to reduce the risk of developing cardiac diseases in the menopause period.

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Authors and Affiliations

  1. Laboratório de Estudos Morfoquantitativo e Imunohistoquímico da USJT, R. Taquari, 546, São Paulo, SP, CEP 03166-000, Brazil

    Aparecida Gabriela Bexiga Veloso, Nathalia Edviges Alves Lima, Elisabete de Marco Ornelas & Laura Beatriz Mesiano Maifrino

  2. Universidade Federal de Goiás, Avenida Esperança s/n, Goiânia, GO, CEP 74690-900, Brazil

    Clever Gomes Cardoso & Mara Rubia Marques

  3. Laboratório de Análises Clínicas da Faculdade de Medicina do ABC, Av. Príncipe de Gales, 821, Santo André, SP, CEP 09060-650, Brazil

    Beatriz da Costa Aguiar Alves Reis & Fernando Luiz Affonso Fonseca

  4. Departamento de Ciências Farmacêuticas da Universidade Federal de São Paulo, R. Prof. Artur Riedel, 275, Diadema, SP, CEP 09972-270, Brazil

    Fernando Luiz Affonso Fonseca

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  1. Aparecida Gabriela Bexiga Veloso
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Correspondence to Laura Beatriz Mesiano Maifrino.

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Veloso, A.G.B., Lima, N.E.A., de Marco Ornelas, E. et al. Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia. Med Mol Morphol 51, 118–127 (2018). https://doi.org/10.1007/s00795-018-0179-x

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  • DOI: https://doi.org/10.1007/s00795-018-0179-x

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