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CEACAM1 is overexpressed in oral tumors and related to tumorigenesis

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Abstract

Carcinoembryonic antigen-related adhesion molecule 1 (CEACAM1) is a type 1 transmembrane glycoprotein belonging to the CEA family, which has been known to exist as either soluble forms in body fluids or membrane-bound forms on the cell surface. Aberrant CEACAM1 expression is associated with tumorigenesis and has been reported in a variety of human tumors, especially malignancies. The aim of this study is to determine the expression of CEACAM1 in oral tumors, trying to study CEACAM1 different expressions as a function of histotype. CEACAM1 expression was observed by immunohistochemistry (IHC) with mouse anti-human antibody for CEACAM1. IHC was performed using avidin–biotin-diaminobenzidine staining. The results were expressed as average score ± SD (0 = negative/8 = highest) for each histotype. Oral tumors expressed more CEACAM1 than normal tissues including squamous and salivary epithelia (P < 0.05). In malignancies, the squamous cell carcinoma overexpressed CEACAM1, compared to well-differentiated squamous cell with more membranous expression; the intermediately and poorly differentiated squamous cell carcinoma showed more cytoplasmic expression (P < 0.05). In addition, the salivary tumors significantly expressed more CEACAM1 than squamous cell carcinoma (P < 0.05). So, we thought oral tumors overexpressed CEACAM1 and the cytoplasmic CEACAM1 might be involved in tumorigenesis, and also CEACAM1 might be regarded as a marker of salivary glandular tumors.

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Acknowledgments

This work was supported by Grants from Shandong Provincial Natural Science Foundation, China (No. ZR2015HM036).

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Authors and Affiliations

  1. Department of Pathology, The Second Hospital, Shandong University, 247 BeiYuan Street, Jinan, 250033, Shandong, People’s Republic of China

    Bing-xin Guan, Jing-yan Yang, Hai-tao Wang & Cheng-jun Zhou

  2. Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, Shandong, People’s Republic of China

    Fu-fang Wang

  3. Key Laboratory of Cardiovascular Proteomics of Shandong Province, 107 Wenhua Xi Road, Jinan, 250012, Shandong, People’s Republic of China

    Fu-fang Wang

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  1. Fu-fang Wang
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Correspondence to Cheng-jun Zhou.

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Wang, Ff., Guan, Bx., Yang, Jy. et al. CEACAM1 is overexpressed in oral tumors and related to tumorigenesis. Med Mol Morphol 50, 42–51 (2017). https://doi.org/10.1007/s00795-016-0147-2

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