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A case of solitary fibrous tumor of the kidney: an immunohistochemical and ultrastructural study with a review of the literature

Medical Molecular Morphology volume 42, pages 239–244 (2009)Cite this article

Abstract

A solitary fibrous tumor (SFT) is an unusual spindle cell neoplasm that usually arises in the pleura but rarely occurs in the kidney. Despite its rarity, histological diagnosis of SFT is crucial to avoid misdiagnosis with other malignant tumors in the kidney. We report a SFT of the left kidney that presented as a malignant tumor on radiographic findings in a 75-year-old Japanese woman. The tumor was well circumscribed and composed of a mixture of spindle cells and dense collagenous bands with no areas of necrosis or cystic changes noted macroscopically or microscopically. Electron microscopy showed fibroblast-like cells with well-developed rough endoplasmic reticulum, surrounded with collagen fibers. Immunohistochemistry revealed reactivity for vimentin, CD34, Bcl-2, and CD99, but no staining for cytokeratin, S-100, desmin, actin, D2-40, or epithelial membrane antigen (EMA). These findings were compatible with those of SFT. Although SFT of the kidney is extremely rare, this tumor must be included in the differential diagnosis when we encounter renal tumors consisting of mesenchymal elements. Immunohistochemical study is the key to diagnosis for SFT, and ultrastructural study is useful for its diagnosis.

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Affiliations

  1. Department of Urology, Nerima Hikarigaoka Hospital, Nihon University School of Medicine, 2-11-1 Hikarigaoka, Nerima-ku, Tokyo, 179-0072, Japan

    Daisaku Hirano

  2. Department of Urology, Nihon University School of Medicine, Tokyo, Japan

    Aya Mashiko, Yasutaka Murata, Katsuhiko Satoh, Taketo Ichinose & Satoru Takahashi

  3. Electron Microscope Division, Nihon University School of Medicine, Tokyo, Japan

    Toyoharu Jike

  4. Department of Pathology, Nihon University School of Medicine, Tokyo, Japan

    Masahiko Sugitani

Authors
  1. Daisaku Hirano
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  2. Aya Mashiko
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  3. Yasutaka Murata
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  4. Katsuhiko Satoh
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  5. Taketo Ichinose
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  6. Satoru Takahashi
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  7. Toyoharu Jike
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  8. Masahiko Sugitani
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Correspondence to Daisaku Hirano.

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Hirano, D., Mashiko, A., Murata, Y. et al. A case of solitary fibrous tumor of the kidney: an immunohistochemical and ultrastructural study with a review of the literature. Med Mol Morphol 42, 239–244 (2009). https://doi.org/10.1007/s00795-009-0456-9

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  • DOI: https://doi.org/10.1007/s00795-009-0456-9

Key words

  • Solitary fibrous tumor
  • Kidney
  • Immunohistochemistry
  • CD34
  • Ultrastructure