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Expression pattern of p63 in oral epithelial lesions and submucous fibrosis associated with betel-quid chewing in Sri Lanka

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Abstract

Betel-quid chewing, which is closely related to the high incidence of oral cancer, is prevalent in Sri Lanka. p63 has a remarkable structural similarity to p53, suggesting an aberrant expression in oral cancer. Using anti-p63 antibody and immunohistochemistry, the present study investigated the expression pattern of p63 in oral epithelial lesions, including different types of squamous cell carcinoma (SCC), different grades of epithelial dysplasia, and submucosal fibrosis associated with betel-quid chewing. Nuclear immunoreactivity for p63 was detected in all the cases, including normal oral epithelium and epithelial lesions. In normal oral epithelium, nuclear positivity for p63 was observed in some of the basal cell layers and focally in the parabasal layer. Nuclear positivity increased in the epithelial lesions. The percentage of positive nuclei in the epithelial lesions was significantly higher than in normal epithelium (P < 0.01) and was also significantly higher in oral submucosal fibrosis than in epithelial dysplasia (P < 0.05). The results indicate that the overexpression of p63 in oral precancerous lesions and SCC in betel-quid chewers in Sri Lanka may be a useful marker for oral precancerous lesions.

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Authors and Affiliations

  1. Office of Deputy Provincial Director of Health Services, Polonnaruwa, Sri Lanka

    Abusayeed M. Haniffa

  2. Department of Dental Science, Division of Oral Medicine & Pathology, Institute of Personalized Medical Science, Health Sciences University of Hokkaido, 2-5 Ainosato, Kita-ku, Sapporo, Hokkaido, 002-8072, Japan

    Masato Saitoh, Yoshihiro Abiko & Hiroki Nagayasu

  3. Department of Pediatric Dentistry, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan

    Masato Saitoh & Maiko Takeshima

  4. Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan

    Yoshihiro Abiko, Michiko Nishimura, Mami Yamazaki & Tohru Kaku

  5. Department of Oral Surgery, University of Hokkaido, Hokkaido, Japan

    Chihiro Sugiura

  6. General Hospital Kalutara, Sri Lanka

    Malantha Muthumala

  7. Department of Preventive and Community Dentistry, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan

    Itsuo Chiba

  8. Department of Oral Surgery, Graduate School of Medicine, Gifu University, Gifu, Japan

    Toshiyuki Shibata

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  1. Abusayeed M. Haniffa
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  2. Masato Saitoh
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  3. Yoshihiro Abiko
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Correspondence to Yoshihiro Abiko.

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Haniffa, A., Saitoh, M., Abiko, Y. et al. Expression pattern of p63 in oral epithelial lesions and submucous fibrosis associated with betel-quid chewing in Sri Lanka. Med Mol Morphol 40, 203–207 (2007). https://doi.org/10.1007/s00795-007-0383-6

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  • DOI: https://doi.org/10.1007/s00795-007-0383-6

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