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Role of β-defensins in oral epithelial health and disease

Medical Molecular Morphology volume 40, pages 179–184 (2007)Cite this article

Abstract

The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. β-Defensins are a group of antimicrobial peptides mainly produced by epithelial cells of many organs including skin, lung, kidney, pancreas, uterus, eye, and nasal and oral mucosa. This review focuses on β-defensins (BDs) in oral epithelia and discusses their importance in oral epithelial health and disease. BDs exhibit antimicrobial activity against oral microbes including periodontitis-related bacteria, Candida, and papilloma virus. Alterative expression of BDs was observed in oral epithelial diseases, including oral inflammatory lesions with and without microbial infection and oral cancer. BDs may be useful in the treatment of oral infectious diseases, ulcerative lesions, and cancer. BDs play an important role in protection against oral microbes and may be used in clinical applications.

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References

  1. B Pomahac T Svensjo F Tao H Brown E Eriksson (1998) ArticleTitleTissue engineering of skin Crit Rev Oral Biol Med 9 333–344 Occurrence Handle9715370 Occurrence Handle1:STN:280:DyaK1czotFWmuw%3D%3D

    PubMed  CAS  Google Scholar 

  2. RB Presland BA Dale (2000) ArticleTitleEpithelial structural protein of the skin and oral cavity: function in health and disease Crit Rev Oral Biol Med 11 383–408 Occurrence Handle11132762 Occurrence Handle1:STN:280:DC%2BD3M7it12ltA%3D%3D Occurrence Handle10.1177/10454411000110040101

    PubMed  CAS  Article  Google Scholar 

  3. AV Amerongen EC Veerman (2002) ArticleTitleSaliva – the defender of the oral cavity Oral Dis 8 12–22 Occurrence Handle11936451 Occurrence Handle10.1034/j.1601-0825.2002.1o816.x

    PubMed  Article  Google Scholar 

  4. Y Abiko M Saitoh (2007) ArticleTitleSalivary defensins and their importance in oral health and disease Curr Pharm Design 13 3065–3072 Occurrence Handle10.2174/138161207782110417 Occurrence Handle1:CAS:528:DC%2BD2sXhtlarurnO

    Article  CAS  Google Scholar 

  5. BA Dale LP Fredericks (2005) ArticleTitleAntimicrobial peptides in the oral environment: expression and function in health and disease Curr Issues Mol Biol 7 119–133 Occurrence Handle16053246 Occurrence Handle1:CAS:528:DC%2BD2MXotFarurs%3D

    PubMed  CAS  Google Scholar 

  6. F Niyonsaba H Ogawa (2005) ArticleTitleProtective roles of the skin against infection: implication of naturally occurring human antimicrobial against beta-defensins, cathelicidin LL-37 and lysozome J Dermatol Sci 40 157–168 Occurrence Handle16150577 Occurrence Handle10.1016/j.jdermsci.2005.07.009 Occurrence Handle1:CAS:528:DC%2BD2MXht1Omsr%2FM

    PubMed  Article  CAS  Google Scholar 

  7. M Pazgier DM Hoover D Yang W Lu J Lubkowski (2006) ArticleTitleHuman beta-defensins Cell Mol Life Sci 63 1294–1313 Occurrence Handle16710608 Occurrence Handle10.1007/s00018-005-5540-2 Occurrence Handle1:CAS:528:DC%2BD28Xmslaisbg%3D

    PubMed  Article  CAS  Google Scholar 

  8. B Dale (2000) ArticleTitlePeriodontal epithelium: a newly recognized role in health and disease Periodontology 30 70–78 Occurrence Handle10.1034/j.1600-0757.2002.03007.x

    Article  Google Scholar 

  9. G Maisetta G Botani S Esin G Raco D Bottai F Favilli W Florio M Campa (2005) ArticleTitleSusceptibility of Streptococcus mutants and Actinobacillus actinomycetemcomitans to bactericidal activity of human beta-defensin 3 in biological fluid Antimicrob Agents Chemother 49 1245–1248 Occurrence Handle15728941 Occurrence Handle10.1128/AAC.49.3.1245-1248.2005 Occurrence Handle1:CAS:528:DC%2BD2MXit12ls7c%3D

    PubMed  Article  CAS  Google Scholar 

  10. K Ouhara H Komatsuzawa S Yamada H Shiba T Fujiwara M Ohara K Sayama K Hashimoto H Kurihara M Sugai (2005) ArticleTitleSusceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cells Antimicrob Agents Chemother 55 888–896 Occurrence Handle1:CAS:528:DC%2BD2MXmtVars7k%3D Occurrence Handle10.1093/jac/dki103

    CAS  Article  Google Scholar 

  11. ME Selsted AJ Ouellette (2005) ArticleTitleMammalian defensins in the antimicrobial immune response Nat Immunol 6 551–557 Occurrence Handle15908936 Occurrence Handle10.1038/ni1206 Occurrence Handle1:CAS:528:DC%2BD2MXktlWit70%3D

    PubMed  Article  CAS  Google Scholar 

  12. ME Klotman TL Chang (2006) ArticleTitleDefensins in innate antiviral immunity Nat Rev Immunol 6 447–456 Occurrence Handle16724099 Occurrence Handle10.1038/nri1860 Occurrence Handle1:CAS:528:DC%2BD28XkvVyrtrk%3D

    PubMed  Article  CAS  Google Scholar 

  13. RI Lehrer (2007) ArticleTitleMultispecific myeloid defensins Curr Opin Hematol 14 16–21 Occurrence Handle17133095 Occurrence Handle10.1097/00062752-200701000-00005 Occurrence Handle1:CAS:528:DC%2BD2sXotVaqsQ%3D%3D

    PubMed  Article  CAS  Google Scholar 

  14. M Saitoh Y Abiko S Shimabukuro K Kusano M Nishimura T Arakawa K Nakashima T Takuma T Kaku S Igarashi (2004) ArticleTitleCorrelated expression of human beta defensin-1, -2, and -3 mRNAs in gingival tissue of young children Arch Oral Biol 49 799–803 Occurrence Handle15308424 Occurrence Handle10.1016/j.archoralbio.2004.04.012 Occurrence Handle1:CAS:528:DC%2BD2cXmslegs7k%3D

    PubMed  Article  CAS  Google Scholar 

  15. BC Schutte JP Mitros JA Bartlett JD Walters HP Jia MJ Welsh TL Casavant PB McCray SuffixJr (2002) ArticleTitleDiscovery of five conserved beta-defensin gene clusters using a computational search strategy Proc Natl Acad Sci U S A 99 2129–2133 Occurrence Handle11854508 Occurrence Handle10.1073/pnas.042692699 Occurrence Handle1:CAS:528:DC%2BD38XitVSrtrc%3D

    PubMed  Article  CAS  Google Scholar 

  16. BA Dale JR Kimball S Krisanaprakornkit F Roberts M Robinovitch R O'Neal EV Valore T Ganz GM Anderson A Weiberg (2001) ArticleTitleLocalized antimicrobial peptide expression in human gingival J Periodont Res 35 1–10

    Google Scholar 

  17. Y Abiko AK Suraweera M Nishimura T Arakawa T Takuma I Mizoguchi T Kaku (2001) ArticleTitleDifferential expression of human beta-defensin 2 in keratinized and non-keratinized oral epithelial lesions; immunohistochemistry and in situ hybridization Virchow Arch 438 248–253 Occurrence Handle10.1007/s004280000303 Occurrence Handle1:CAS:528:DC%2BD3MXhsFGlsLw%3D

    Article  CAS  Google Scholar 

  18. Y Abiko M Nishimura K Kusano M Yamazaki T Arakawa T Takuma T Kaku (2003) ArticleTitleUpregulated expression of human β-defensin-1 and -3 mRNA during differentiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b J Dermatol Sci 31 225–228 Occurrence Handle12727027 Occurrence Handle10.1016/S0923-1811(03)00007-0 Occurrence Handle1:CAS:528:DC%2BD3sXjtlWktrk%3D

    PubMed  Article  CAS  Google Scholar 

  19. J Harder U Meyer-Hoffert K Wehkamp L Schwichtenberg JM Schröder (2004) ArticleTitleDifferential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid J Invest Dermatol 123 522–529 Occurrence Handle15304092 Occurrence Handle10.1111/j.0022-202X.2004.23234.x Occurrence Handle1:CAS:528:DC%2BD2cXnsValtLw%3D

    PubMed  Article  CAS  Google Scholar 

  20. I Hosokawa Y Hosokawa H Komatsuzawa RB Goncalves N Karimbux MH Napimoga M Seki K Ouhara M Sugai MA Taubman T Kawai (2006) ArticleTitleInnate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue Clin Exp Immunol 146 218–225 Occurrence Handle17034573 Occurrence Handle10.1111/j.1365-2249.2006.03200.x Occurrence Handle1:CAS:528:DC%2BD28XhtlCgtLbN

    PubMed  Article  CAS  Google Scholar 

  21. Q Lu LP Samaranayake RP Darveau L Jin (2005) ArticleTitleExpression of human beta-defensin-3 in gingival epithelia J Periodont Res 40 474–481 Occurrence Handle16302926 Occurrence Handle10.1111/j.1600-0765.2005.00827.x Occurrence Handle1:CAS:528:DC%2BD28XitFGqtQ%3D%3D

    PubMed  Article  CAS  Google Scholar 

  22. K Ouhara H Komatsuzawa H Shibata Y Uchida T Kawai K Sayama K Hashimoto MA Taubman H Kurihara M Sugai (2006) ArticleTitleActinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells Infect Immun 74 5211–5220 Occurrence Handle16926414 Occurrence Handle10.1128/IAI.00056-06 Occurrence Handle1:CAS:528:DC%2BD28Xpt1SlsrY%3D

    PubMed  Article  CAS  Google Scholar 

  23. Y Taguchi H Imai (2006) ArticleTitleExpression of beta-defensin-2 in human gingival epithelial cells in response to challenge with Porphyromonas gingivalis in vitro J Periodont Res 41 334–339 Occurrence Handle16827729 Occurrence Handle10.1111/j.1600-0765.2006.00879.x Occurrence Handle1:CAS:528:DC%2BD28XptFWku78%3D

    PubMed  Article  CAS  Google Scholar 

  24. A Vankeerberghen H Nuytten K Dierickx M Quirynen JJ Cassiman H Cuppens (2005) ArticleTitleDifferential induction of human beta-defensin expression by periodontal commensals and pathogens in periodontal pocket epithelial cells J Periodontol 76 1293–1303 Occurrence Handle16101361 Occurrence Handle10.1902/jop.2005.76.8.1293 Occurrence Handle1:CAS:528:DC%2BD2MXhtVemsrjI

    PubMed  Article  CAS  Google Scholar 

  25. H Dommisch Y Acil A Dunsche J Winter S Jespen (2005) ArticleTitleDifferential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival disease Oral Microbial Immunol 30 186–190 Occurrence Handle10.1111/j.1399-302X.2005.00211.x

    Article  Google Scholar 

  26. T Noguchi H Shiba H Komatsuzawa N Mizuno Y Uchida K Ohuara R Asakawa S Kudo H Kawaguchi M Sugai H Kurihara (2003) ArticleTitleSyntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans Inflammation 27 341–349 Occurrence Handle14760942 Occurrence Handle10.1023/B:IFLA.0000006702.27906.e9 Occurrence Handle1:CAS:528:DC%2BD3sXpsV2kt74%3D

    PubMed  Article  CAS  Google Scholar 

  27. S Krisanaprakornkit A Weinberg CN Perez BA Dale (1998) ArticleTitleExpression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue Infect Immun 66 4222–4228 Occurrence Handle9712771 Occurrence Handle1:CAS:528:DyaK1cXlslCrsLk%3D

    PubMed  CAS  Google Scholar 

  28. AR Kurland H Schreiner G Diamond (2006) ArticleTitleIn vivo beta-defensin gene expression in rat gingival epithelium in response to Actinobacillus actinomycetemcomitans infection J Periodont Res 41 567–572 Occurrence Handle17076783 Occurrence Handle10.1111/j.1600-0765.2006.00909.x Occurrence Handle1:CAS:528:DC%2BD2sXhtFCisw%3D%3D

    PubMed  Article  CAS  Google Scholar 

  29. K Sawaki N Mizukawa T Yamaai J Fukunaga T Sugahara (2002) ArticleTitleImmunohistochemical study on expression of alpha-defensin and beta-defensin-2 in human buccal epithelia with candidiasis Oral Dis 8 37–41 Occurrence Handle11936455 Occurrence Handle10.1034/j.1601-0825.2002.1o770.x Occurrence Handle1:STN:280:DC%2BD383gtlyrtg%3D%3D

    PubMed  Article  CAS  Google Scholar 

  30. JE Meyer J Harder T Gorogh JB Weise S Schubert D Janssen S Maune (2004) ArticleTitleHuman beta-defensin-2 in oral cancer with opportunistic Candida infection Anticancer Res 24 1025–1030 Occurrence Handle15161058 Occurrence Handle1:CAS:528:DC%2BD2cXkvVenu7g%3D

    PubMed  CAS  Google Scholar 

  31. Q Lu JA Jayatilake LP Samaranayake L Jin (2006) ArticleTitleHyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis J Invest Dermatol 126 2049–2056 Occurrence Handle16741514 Occurrence Handle10.1038/sj.jid.5700346 Occurrence Handle1:CAS:528:DC%2BD28XotFCjur8%3D

    PubMed  Article  CAS  Google Scholar 

  32. Y Abiko Y Jinbu T Noguchi M Nishimura K Kusano P Amaratunga T Shibata T Kaku (2002) ArticleTitleUpregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis; an immunohistochemical study Pathol Res Pract 198 537–542 Occurrence Handle12389997 Occurrence Handle10.1078/0344-0338-00298 Occurrence Handle1:CAS:528:DC%2BD38XovFaguro%3D

    PubMed  Article  CAS  Google Scholar 

  33. A Weinberg ME Quinones-Mateu MM Lederman (2006) ArticleTitleRole of human beta-defensins in HIV infection Adv Dent Res 19 42–48 Occurrence Handle16672548 Occurrence Handle1:STN:280:DC%2BD283kslyqtw%3D%3D

    PubMed  CAS  Google Scholar 

  34. R Gropp M Frye TO Wagner J Bargon (1999) ArticleTitleEpithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy Hum Gene Ther 10 957–964 Occurrence Handle10223729 Occurrence Handle10.1089/10430349950018355 Occurrence Handle1:CAS:528:DyaK1MXis12ksbs%3D

    PubMed  Article  CAS  Google Scholar 

  35. KT Chong L Xiang X Wang EL Jun LF Xi JM Schweinfurth (2006) ArticleTitleHigh level expression of human epithelial beta-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions Virol J 3 75 Occurrence Handle16961924 Occurrence Handle10.1186/1743-422X-3-75 Occurrence Handle1:CAS:528:DC%2BD28XhtV2itbzO

    PubMed  Article  CAS  Google Scholar 

  36. M Saitoh Y Kurashige M Yamazaki M Nishimura S Nakamura D Noro M Takeshima T Arakawa T Takuma S Igarashi T Kaku T Inoue Y Abiko (2007) ArticleTitleIncreased expression of beta-defensin-2 and -3 during the development of autoimmune sialoadenitis in MRL/lpr mice Med Mol Morphol 40 157–162 Occurrence Handle17874048 Occurrence Handle10.1007/s00795-007-0375-6 Occurrence Handle1:CAS:528:DC%2BD2sXhtVCgu7jP

    PubMed  Article  CAS  Google Scholar 

  37. S Kawasaki S Kawamoto N Yokoi C Connon Y Minesaki S Kinoshita K Okubo (2003) ArticleTitleUp-regulated gene expression in the conjunctival epithelium of patients with Sjogren's syndrome Exp Eye Res 77 17–26 Occurrence Handle12823984 Occurrence Handle10.1016/S0014-4835(03)00087-3 Occurrence Handle1:CAS:528:DC%2BD3sXkvVCgtbo%3D

    PubMed  Article  CAS  Google Scholar 

  38. Y Abiko J Mitamura M Nishimura T Muramatsu T Inoue M Shimono T Kaku (1999) ArticleTitlePattern of expression of beta-defensins in oral squamous cell carcinoma Cancer Lett 143 37–43 Occurrence Handle10465335 Occurrence Handle10.1016/S0304-3835(99)00171-8 Occurrence Handle1:CAS:528:DyaK1MXltlKjurg%3D

    PubMed  Article  CAS  Google Scholar 

  39. CD Donald CQ Sun SD Lim J Macoska C Cohen MB Amin AN Young TA Ganz FF Marshall JA Petros (2003) ArticleTitleCancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas Lab Invest 83 501–505 Occurrence Handle12695553 Occurrence Handle1:CAS:528:DC%2BD3sXisFCjsbs%3D

    PubMed  CAS  Google Scholar 

  40. T Gambichler M Skrygan J Huyn FG Bechara M Sand P Altmeyer A Kreuter (2006) ArticleTitlePattern of mRNA expression of beta-defensins in basal cell carcinoma BMC Cancer 6 163 Occurrence Handle16796735 Occurrence Handle10.1186/1471-2407-6-163 Occurrence Handle1:CAS:528:DC%2BD28Xns1eqsrw%3D

    PubMed  Article  CAS  Google Scholar 

  41. CQ Sun R Arnold C Fernandez-Golarz AB Parrish T Almekinder J He SM Ho P Svoboda J Pohl FF Marshall JA Petros (2006) ArticleTitleHuman β-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma Cancer Res 66 8542–8549 Occurrence Handle16951166 Occurrence Handle10.1158/0008-5472.CAN-06-0294 Occurrence Handle1:CAS:528:DC%2BD28XovF2it7w%3D

    PubMed  Article  CAS  Google Scholar 

  42. K Sawaki N Mizukawa T Yamaai T Yoshimoto M Nakano T Sugahara (2002) ArticleTitleHigh concentration of beta-defensin-2 in oral squamous cell carcinoma Anticancer Res 22 2103–2107 Occurrence Handle12174890 Occurrence Handle1:CAS:528:DC%2BD38XmsF2ltro%3D

    PubMed  CAS  Google Scholar 

  43. M Nishimura Y Abiko Y Kurashige M Takeshima M Yamazaki K Kusano M Saitoh K Nakashima T Inoue T Kaku (2004) ArticleTitleEffect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines J Dermatol Sci 36 87–95 Occurrence Handle15519138 Occurrence Handle1:CAS:528:DC%2BD2cXptFOlsrg%3D

    PubMed  CAS  Google Scholar 

  44. A Weinberg S Krisanaprakornkit BA Dale (1998) ArticleTitleEpithelial antimicrobial peptides: review and significance for oral applications Crit Rev Oral Biol Med 9 399–414 Occurrence Handle9825219 Occurrence Handle1:CAS:528:DyaK1cXnslSqtb8%3D

    PubMed  CAS  Google Scholar 

  45. WJ Killoy (1998) ArticleTitleChemical treatment of periodontitis: local delivery of antimicrobials Int Dent J 48 IssueIDsuppl 1 305–315 Occurrence Handle9779113 Occurrence Handle1:STN:280:DyaK1cvlt1Wgtw%3D%3D

    PubMed  CAS  Google Scholar 

  46. SG Ciancio (1999) ArticleTitleSite specific delivery of antimicrobial agents for periodontal disease Gen Dent 47 172–178 Occurrence Handle10687494 Occurrence Handle1:STN:280:DC%2BD3c7lt1Wisg%3D%3D

    PubMed  CAS  Google Scholar 

  47. K Schwach-Abdellaoui N Vivien-Castioni R Gurry (2000) ArticleTitleLocal delivery of antimicrobial agents for the treatment of periodontal diseases Eur J Pharm Biopharm 50 83–99 Occurrence Handle10840194 Occurrence Handle10.1016/S0939-6411(00)00086-2 Occurrence Handle1:CAS:528:DC%2BD3cXjslyisr8%3D

    PubMed  Article  CAS  Google Scholar 

  48. D Sawamura M Goto A Shibaki M Akiyama JR McMillan Y Abiko H Shimizu (2005) ArticleTitleBeta defensin-3 engineered epidermis shows highly protective effect for bacterial infection Gene Ther 12 857–861 Occurrence Handle15729370 Occurrence Handle10.1038/sj.gt.3302472 Occurrence Handle1:CAS:528:DC%2BD2MXjvFeksbs%3D

    PubMed  Article  CAS  Google Scholar 

  49. K Okumura A Itoh E Isogai K Hirose Y Hosokawa Y Abiko T Shibata M Hirata H Isogai (2004) ArticleTitleC-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells Cancer Lett 212 185–194 Occurrence Handle15279899 Occurrence Handle10.1016/j.canlet.2004.04.006 Occurrence Handle1:CAS:528:DC%2BD2cXlvFyqtb8%3D

    PubMed  Article  CAS  Google Scholar 

  50. Saitoh M, Abiko Y, Nishimura M, Yamazaki M, Noro D, Igarashi S, Nagayasu H (2006) Increased expression of beta-defensins inhibits carcinoma cell migration. Presented at 35th annual meeting & exhibition of the American Association for Dental Research, Orland, USA

  51. A Biragyn M Surenhu D Yang PA Ruffini BA Haines E Klyushnenkova JJ Oppenheim LW Kwak (2001) ArticleTitleMediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens J Immunol 167 6644–6 Occurrence Handle11714836 Occurrence Handle1:CAS:528:DC%2BD3MXovVChsL0%3D

    PubMed  CAS  Google Scholar 

  52. J Harder J Bartels E Christophers JM Schroder (1997) ArticleTitleA peptide antibiotic from human skin Nature (Lond) 387 IssueID6636 861 Occurrence Handle10.1038/43088 Occurrence Handle1:CAS:528:DyaK2sXkt1Gmtbo%3D

    Article  CAS  Google Scholar 

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Affiliations

  1. Department of Dental Science, Division of Oral Medicine and Pathology, Institute of Personalized Medical Science, Health Sciences University of Hokkaido, 2-5 Ainosato, Kita-ku, Sapporo, Hokkaido, 002-8072, Japan

    Yoshihiro Abiko & Masto Saitoh

  2. Division of Clinical Oral Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan

    Yoshihiro Abiko, Masto Saitoh, Michiko Nishimura, Mami Yamazaki & Tohru Kaku

  3. Division of Pediatric Dentistry, Departmento of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan

    Masto Saitoh

  4. Department of Dermatology, School of Medicine, Hirosaki University Hirosaki, Anomri, Japan

    Daisuke Sawamura

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  1. Yoshihiro Abiko
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  2. Masto Saitoh
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  4. Mami Yamazaki
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  5. Daisuke Sawamura
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Correspondence to Yoshihiro Abiko.

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Abiko, Y., Saitoh, M., Nishimura, M. et al. Role of β-defensins in oral epithelial health and disease. Med Mol Morphol 40, 179–184 (2007). https://doi.org/10.1007/s00795-007-0381-8

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Key words

  • β-defensins
  • Antimicrobial peptide
  • Oral epithelial diseases