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Invasive micropapillary carcinoma of the colon: an immunohistochemical study

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Abstract

Invasive micropapillary carcinoma has recently been reported in various anatomic sites. In this article, we report a case of micropapillary carcinoma of the sigmoid colon. A 70-year-old Japanese woman presented with bloody stool for 2 months. Detailed examination disclosed ulcerative and localized tumor in the sigmoid colon. Histological examination of the colon tumor showed a combination of conventional adenocarcinoma (60%) and micropapillary carcinoma (40%). Immunohistochemically, micropapillary carcinoma cells were positive for cytokeratin (CK) 20, carcinoembryonic antigen, and CA125, but negative for CK7, thyroid transcription factor-1, surfactant apoprotein A, estrogen receptor, and progesterone receptor. Additionally, the immunohistochemistry of epithelial membrane antigen revealed reverse polarity of neoplastic cells. Results of conventional adenocarcinoma were basically identical to those of micropapillary carcinoma. In the stroma of both conventional adenocarcinoma and micropapillary carcinoma, many myofibroblasts were present and CD34-positive stromal cells were absent. Finally, we report the fourth case of micropapillary carcinoma arising in the colon. Immunohistochemical results of CK7(−)/CK20(+) strongly suggest the colon as a primary site of micropapillary carcinoma. Additionally, micropapillary carcinoma of the colon may cause a similar stromal reaction to conventional adenocarcinoma of the colon.

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Authors and Affiliations

  1. Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi City, Kochi, 780-8562, Japan

    Naoto Kuroda, Masahiko Ohara, Takashi Hirouchi & Keiko Mizuno

  2. Department of Surgery, Kochi Red Cross Hospital, Kochi, Japan

    Kazuhisa Oonishi

  3. Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

    Yoshihiro Hayashi & Gang-Hong Lee

Authors
  1. Naoto Kuroda
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  2. Kazuhisa Oonishi
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  3. Masahiko Ohara
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  4. Takashi Hirouchi
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  5. Keiko Mizuno
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  6. Yoshihiro Hayashi
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  7. Gang-Hong Lee
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Correspondence to Naoto Kuroda.

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Kuroda, N., Oonishi, K., Ohara, M. et al. Invasive micropapillary carcinoma of the colon: an immunohistochemical study. Med Mol Morphol 40, 226–230 (2007). https://doi.org/10.1007/s00795-007-0353-z

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  • DOI: https://doi.org/10.1007/s00795-007-0353-z

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