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Emotional intelligence mediates the protective role of the orbitofrontal cortex spontaneous activity measured by fALFF against depressive and anxious symptoms in late adolescence

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Abstract

As a stable personality construct, trait emotional intelligence (TEI) refers to a battery of perceived emotion-related skills that make individuals behave effectively to adapt to the environment and maintain well-being. Abundant evidence has consistently shown that TEI is important for the outcomes of many mental health issues, particularly depression and anxiety. However, the neural substrates involved in TEI and the underlying neurobehavioral mechanism of how TEI reduces depression and anxiety symptoms remain largely unknown. Herein, resting-state functional magnetic resonance imaging and a group of behavioral measures were applied to examine these questions among a large sample comprising 231 general adolescent students aged 16–20 years (52% female). Whole-brain correlation analysis and prediction analysis demonstrated that TEI was negatively linked with spontaneous activity (measured with the fractional amplitude of low-frequency fluctuations) in the bilateral medial orbitofrontal cortex (OFC), a critical site implicated in emotion-related processes. Furthermore, structural equation modeling analysis found that TEI mediated the link of OFC spontaneous activity to depressive and anxious symptoms. Collectively, the current findings present new evidence for the neurofunctional bases of TEI and suggest a potential “brain–personality–symptom” pathway for alleviating depressive and anxious symptoms among students in late adolescence.

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Data availability

The data and code that support the findings of this study are available from the corresponding author upon reasonable request. The data and code sharing adopted by the authors comply with the requirements of the funding institute and the institutional ethics approval.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (Grant Nos. 81820108018, 82027808, 81621003 and 31800963), the Sichuan Science and Technology Program (No. 2022YFS0178), and the Post-Doctor Research Project, West China Hospital, Sichuan University (Grant No. 2020HXBH092).

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Author notes

  1. Xun Zhang and Bochao Cheng are co-first authors in this work.

Authors and Affiliations

  1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China

    Xun Zhang, Xueling Suo, Nanfang Pan, Taolin Chen, Song Wang & Qiyong Gong

  2. Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China

    Xun Zhang, Xueling Suo, Nanfang Pan, Taolin Chen & Song Wang

  3. Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China

    Xun Zhang, Xueling Suo, Nanfang Pan, Taolin Chen & Song Wang

  4. Department of Radiology, West China Second University Hospital of Sichuan University, Chengdu, China

    Bochao Cheng

  5. School of Public Affairs, Chongqing University, Chongqing, China

    Xun Yang

  6. Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China

    Qiyong Gong

Authors
  1. Xun Zhang
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  2. Bochao Cheng
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  3. Xun Yang
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  4. Xueling Suo
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  5. Nanfang Pan
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  6. Taolin Chen
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  7. Song Wang
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  8. Qiyong Gong
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Corresponding authors

Correspondence to Song Wang or Qiyong Gong.

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Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

The study was approved by the local research ethics committee of West China Hospital of Sichuan University.

Consent to participate

All participants and their guardians gave their written informed consent before the experiments.

Supplementary Information

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Zhang, X., Cheng, B., Yang, X. et al. Emotional intelligence mediates the protective role of the orbitofrontal cortex spontaneous activity measured by fALFF against depressive and anxious symptoms in late adolescence. Eur Child Adolesc Psychiatry 32, 1957–1967 (2023). https://doi.org/10.1007/s00787-022-02020-8

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  • DOI: https://doi.org/10.1007/s00787-022-02020-8

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