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Evidence mapping of clinical practice guidelines recommendations and quality for depression in children and adolescents

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Abstract

This study systematically reviewed the clinical practice guidelines (CPGs) for depression in children and adolescents and assessed the quality and recommendation consistency of those CPGs. Evidence mapping was presented to illustrate the research trends and identify gaps to guide future research. Literature on CPGs for depression was systematically collected from PubMed, Embase, Web of Science, guideline databases, and psychiatric association/ society websites. The basic information, recommendations, methodological quality, and reporting quality of CPGs were extracted, and the supporting evidence strength for the included CPGs was analyzed in Excel. Four appraisers independently assessed the eligible CPGs using AGREE II instrument and the RIGHT checklist. All recommendations from the CPGs were summarized and analyzed, and the evidence mapping bubble charts were plotted in Excel. After excluding 15,184 records, 12 depression CPGs were eventually proved eligible, six of which were of high quality and six medium quality. A total of 39 major recommendations were summarized, 35 of which were supported by high-quality CPGs. Although direct comparisons are challenging due to differences in grading schemes and research quality, most CPGs share many pivotal recommendations that can help guide clinical practice. However, the evidence for some clinical problems is still lacking. Thus, more research is necessary on the screening and treatment of children and adolescents to put forward more evidence-based and high-quality recommendations.

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Acknowledgements

We have received funding from Gansu Province Science and Technology Planning Project, National Key R&D Program Funded Projects and The Fundamental Research Funds for the Central Universities provided funding for this study. We would like to thank Ya Gao and Yitong Cai for their methodological support and assistance with the final editing of the article.

Funding

This study was funded by Gansu Province Science and Technology Planning Project (Grant/Award Numbers: 20CX4ZA027, 20CX9ZA112); National Key R&D Program Funded Projects (Grant/Award Number: 2019YFC1709805); The Fundamental Research Funds for the Central Universities (Grant/Award Number: 3332020027).

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Author notes

  1. Meili Yan, Lingmin Chen and Min Yang contributed equally to this work and were considered as co-first authors.

Authors and Affiliations

  1. Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, Gansu, China

    Meili Yan, Li Zhang, Mingming Niu, Fangfang Wu, Yamin Chen, Ziwei Song & Jinhui Tian

  2. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, No.199, Donggang West Road, Lanzhou, Gansu, China

    Meili Yan, Li Zhang, Mingming Niu, Fangfang Wu, Yamin Chen, Ziwei Song & Jinhui Tian

  3. Department of Anesthesiology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, Sichuan, China

    Lingmin Chen

  4. Comprehensive Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Min Yang

  5. The Third Ward of Cardiovascular Clinical Medical Center, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu, China

    Li Zhang

  6. Shangluo Vocational and Technical College, Shangluo, Shanxi, China

    Fangfang Wu

  7. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    Yonggang Zhang

  8. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, China

    Jiang Li

  9. WHO Collaborating Center for Guideline Implementation and Knowledge Translation, Lanzhou, Gansu, China

    Jinhui Tian

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  1. Meili Yan
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Contributions

JH-T and ML-Y carried out the study design, JH-T and JL conducted a literature search. ML-Y, LZ, MM-N, FF-W, YM-C, ZW-S, and YG-Z contributed to the data acquisition and drafted parts of the methods and results sections of the manuscript. ML-Y, LM-C and MY contributed to data interpretation and statistical analysis, and drafted the rest of the manuscript. JH-T and JL supervised and provide mentorship. All authors edited the report and contributed to the revision of the report. All authors reviewed the manuscript, approved the final draft, and agreed to submit it for publication.

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Correspondence to Jiang Li or Jinhui Tian.

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Yan, M., Chen, L., Yang, M. et al. Evidence mapping of clinical practice guidelines recommendations and quality for depression in children and adolescents. Eur Child Adolesc Psychiatry 32, 2091–2108 (2023). https://doi.org/10.1007/s00787-022-01958-z

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