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European Child & Adolescent Psychiatry

, Volume 28, Issue 1, pp 31–42 | Cite as

Education and employment trajectories from childhood to adulthood in individuals with 22q11.2 deletion syndrome

  • Mariela MoshevaEmail author
  • Virginie Pouillard
  • Yael Fishman
  • Lydia Dubourg
  • Dafna Sofrin-Frumer
  • Yaffa Serur
  • Abraham Weizman
  • Stephan Eliez
  • Doron Gothelf
  • Maude Schneider
Original Contribution

Abstract

22q11.2 deletion syndrome (22q11.2DS) is the most common known microdeletion in humans occurring in 1 out of 2000–4000 live births, with increasing numbers of individuals with the microdeletion living into adulthood. The aim of the study was to explore the education and employment trajectories of individuals with 22q11.2DS from childhood to adulthood in a large cohort composed of two significant samples. 260 individuals with 22q11.2DS, 134 male and 126 female, aged 5–59 years (mean age 21.3 ± 10.8 years) were evaluated at two sites, Geneva (GVA) and Tel Aviv (TA). Psychiatric comorbidities, IQ score, and adaptive functioning were assessed using gold-standard diagnostic tools. Demographic factors, such as data about education, employment, marital status, and living status, were collected. Children entering elementary school (5–12 years) were significantly more likely to attend a mainstream school, while adolescents were significantly more likely to attend special education schools (p < 0.005). Cognitive abilities, and not adaptive functioning, predicted school placement. Among adults with 22q11.2DS (n = 138), 57 (41.3%) were unemployed, 46 (33.3%) were employed in open market employment, and 35 (25.4%) worked in assisted employment. In adulthood, adaptive functioning more than cognitive abilities predicted employment. Surprisingly, psychotic spectrum disorders were not found to be associated with employment. Individuals with 22q11.2DS are characterized by heterogeneity in educational and employment profiles. We found that cognitive abilities and adaptive functioning, and not the presence of psychiatric disorders, are key factors in school placement and employment. These factors should, therefore, be taken into account when planning optimal development of individuals with 22q11.2DS.

Keywords

Velocardiofacial syndrome Education Adaptive functioning VABS Schizophrenia Psychosis Employment 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

787_2018_1184_MOESM1_ESM.docx (13 kb)
Supplementary material 1 (DOCX 12 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Mariela Mosheva
    • 1
    • 2
    Email author
  • Virginie Pouillard
    • 3
  • Yael Fishman
    • 1
  • Lydia Dubourg
    • 3
  • Dafna Sofrin-Frumer
    • 1
  • Yaffa Serur
    • 1
  • Abraham Weizman
    • 2
    • 6
  • Stephan Eliez
    • 3
    • 4
  • Doron Gothelf
    • 1
    • 2
    • 5
  • Maude Schneider
    • 3
  1. 1.The Child Psychiatry Division, Edmond and Lily Safra Children’s HospitalSheba Medical CenterTel HashomerIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Developmental Imaging and Psychopathology Lab, Department of Psychiatry, School of MedicineUniversity of GenevaGenevaSwitzerland
  4. 4.Department of Genetic Medicine and Development, School of MedicineUniversity of GenevaGenevaSwitzerland
  5. 5.Sagol School of NeuroscienceTel Aviv UniversityTel AvivIsrael
  6. 6.Geha Mental Health Center and Felsenstein Medical Research CenterPetah TikvaIsrael

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