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European Child & Adolescent Psychiatry

, Volume 27, Issue 3, pp 267–277 | Cite as

ADHD is associated with migraine: a systematic review and meta-analysis

  • Haitham Salem
  • David Vivas
  • Fei Cao
  • Iram F. Kazimi
  • Antonio L. Teixeira
  • Cristian P. Zeni
Review

Abstract

An association between primary headaches and attention-deficit/hyperactivity disorder (ADHD) has long been suggested. Moreover, headache is regarded as a common side effect of stimulants, the most effective treatment for ADHD. So far, no systematic review has evaluated the potential association between ADHD and headache. We performed a systematic review of the literature and a meta-analysis of all reported studies on ADHD and primary headaches. Our analysis showed a positive association between ADHD and migraine (OR 1.322, 95% CI 1.018–1717, p value 0.036), but not with tension-type headache. There is a significant association between migraine and ADHD. The mechanisms underlying this association remain to be elucidated, warranting further studies.

Keywords

ADHD Headache Migraine Tension-type headache Meta-analysis Stimulants 

Notes

Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interests associated and that no funding of any kind is associated with this work.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Haitham Salem
    • 1
  • David Vivas
    • 2
  • Fei Cao
    • 1
  • Iram F. Kazimi
    • 2
  • Antonio L. Teixeira
    • 1
  • Cristian P. Zeni
    • 2
  1. 1.Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical SchoolUniversity of Texas Health Science CenterHoustonUSA
  2. 2.Pediatric Mood Disorders/ADHD Across Lifespan Programs, Department of Psychiatry and Behavioral Sciences, McGovern Medical SchoolUniversity of Texas Health Science CenterHoustonUSA

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