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Health-related quality of life, anxiety and depression in parents of adolescents with Gilles de la Tourette syndrome: a controlled study

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Abstract

Our objectives were to assess health-related quality of life (HRQoL), anxiety, depression of Gilles de la Tourette syndrome (GTS) adolescents’ parents compared to controls; to assess GTS adolescents’ HRQoL compared to controls; to investigate which parental and adolescent variables are associated with poorer parental HRQoL. The controlled study involved GTS outpatients and their parents, adolescent healthy controls matched for gender and age and their parents. Parents’ HRQoL was assessed using SF-36 and WHOQOL-BREF; anxiety, depression using HADS. Adolescents’ HRQoL was assessed by adolescents using VSP-A instrument and by their parents using VSP-P. A total of 75 GTS adolescents, 75 mothers, 63 fathers were compared to 75 control adolescents, 75 mothers, 62 fathers. GTS mothers had worse HRQoL than controls on 5 of the 8 SF-36 dimensions and 1 of the 4 WHOQOL-BREF dimensions, while GTS fathers had worse HRQoL on 2 of the WHOQOL-BREF dimensions. GTS mothers had poorer HRQoL than fathers. GTS mothers had more depression than control mothers and GTS fathers had more anxiety than control fathers. GTS adolescents had worse HRQoL than controls on 5 of the 9 VSP-A dimensions. Factors significantly related to parental HRQoL were anxiety, depression, GTS adolescents’ HRQoL and, concerning mothers, behavioural and emotional adolescents’ problems; concerning fathers, severity of vocal tics, duration since first symptoms. This study provides a better understanding of poorer HRQoL and psychiatric morbidity of GTS adolescents’ parents. Clinicians should pay attention to their emotional well-being and HRQoL and be aware that mothers and fathers are differently affected.

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Acknowledgements

The authors thank the patients who participated and J. Watts for advice on the English version. Members of the SYNDROME DE GILLES DE LA TOURETTE Study Group: C. Angonin, C. Auclair, E. Deniau, Ph Derost, L. Gerbaud, A. Hartmann, I. Jalenques, G. Legrand, A. Macleod, M. Marcheix, D. Morand, J. Müllner, C. Ramanoel.

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Authors and Affiliations

  1. Psychiatrie de l’Adulte A et Psychologie médicale Pôle de Psychiatrie, CHU Clermont-Ferrand, 63003, Clermont-Ferrand Cedex1, France

    Isabelle Jalenques & G. Legrand

  2. Clermont Université, Université d’Auvergne Clermont 1, UFR Médecine, Equipe d’Accueil 7280, 63001, Clermont-Ferrand, France

    Isabelle Jalenques, G. Legrand, Magali Marcheix & Clémentine Ramanoel

  3. Santé Publique, CHU Clermont-Ferrand, 63003, Clermont-Ferrand Cedex 1, France

    Candy Auclair

  4. Clermont Université, Université d’Auvergne Clermont, Equipe d’Accueil 4681, PEPRADE, 63000, Clermont-Ferrand, France

    Candy Auclair

  5. DRCI, CHU Clermont-Ferrand, 63003, Clermont-Ferrand Cedex 1, France

    D. Morand

  6. Département de Neurologie, Pôle des Maladies du Système Nerveux, Groupe Hospitalier Pitié-Salpêtrière, Centre de référence ‘Syndrome Gilles de la Tourette’, 75013, Paris, France

    Andreas Hartmann

  7. Neurologie, CHU Clermont-Ferrand, 63003, Clermont-Ferrand Cedex 1, France

    Ph. Derost

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  1. Isabelle Jalenques
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  7. Andreas Hartmann
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  8. Ph. Derost
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The Syndrome de Gilles de La Tourette Study Group

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Correspondence to Isabelle Jalenques.

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Funding

The authors thank the university hospital of Clermont-Ferrand and the French Association of Gilles de la Tourette Syndrome (AFSGT) for their financial support.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Members of the SYNDROME DE GILLES DE LA TOURETTE Study Group are listed in Acknowledgements section.

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Jalenques, I., Auclair, C., Morand, D. et al. Health-related quality of life, anxiety and depression in parents of adolescents with Gilles de la Tourette syndrome: a controlled study. Eur Child Adolesc Psychiatry 26, 603–617 (2017). https://doi.org/10.1007/s00787-016-0923-5

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