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Neurocognitive performance in children and adolescents with bipolar disorder: a review

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Abstract

A number of studies have reported the evidence of cognitive deficits in adult bipolar patients. Recently, there has been a shift in research on neurocognitive performance in bipolar disorder (BD) towards examining younger age groups. A review of the literature on neurocognitive impairments in BD in childhood and adolescence was conducted. We searched systematically for studies in samples of age groups younger than 18 years of age in average that included either a healthy control group or normative data for the cognitive tests used. Twenty-one original articles were found and reviewed. Children and adolescents with BD show deficits in a variety of cognitive areas. The most consistent results were found for impairments in verbal memory. A majority of studies also indicated impairments in working memory. Similar pattern of neurocognitive impairment was found in children and adolescents as compared to adults suffering from BD. The neurocognitive deficits need to be recognized and incorporated into individual treatment programs.

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References

  1. Altshuler LL, Bearden CE, Green MF, van Gorp W, Mintz J (2008) A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study. Psychiatry Res 157:289–293

    Article  PubMed  Google Scholar 

  2. Arts B, Jabben N, Krabbendam L, van Os J (2008) Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med 38:771–785

    Article  PubMed  CAS  Google Scholar 

  3. Balanza-Martinez V, Rubio C, Selva-Vera G, Martinez-Aran A, Sanchez-Moreno J, Salazar-Fraile J, Vieta E, Tabares-Seisdedos R (2008) Neurocognitive endophenotypes (endophenocognitypes) from studies of relatives of bipolar disorder subjects: a systematic review. Neurosci Biobehav Rev 32:1426–1438

    Article  PubMed  Google Scholar 

  4. Balanza-Martinez V, Selva G, Martinez-Aran A, Prickaerts J, Salazar J, Gonzalez-Pinto A, Vieta E, Tabares-Seisdedos R (2010) Neurocognition in bipolar disorders—a closer look at comorbidities and medications. Eur J Pharmacol 626:87–96

    Article  PubMed  CAS  Google Scholar 

  5. Bearden CE, Glahn DC, Caetano S, Olvera RL, Fonseca M, Najt P, Hunter K, Pliszka SR, Soares JC (2007) Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Bipolar Disord 9(Suppl 1):145–159

    Article  PubMed  Google Scholar 

  6. Birmaher B, Axelson D, Goldstein B, Strober M, Gill MK, Hunt J, Houck P, Ha W, Iyengar S, Kim E, Yen S, Hower H, Esposito-Smythers C, Goldstein T, Ryan N, Keller M (2009) Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) study. Am J Psychiatry 166:795–804

    Article  PubMed  Google Scholar 

  7. Birmaher B, Axelson D, Strober M, Gill MK, Valeri S, Chiappetta L, Ryan N, Leonard H, Hunt J, Iyengar S, Keller M (2006) Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63:175–183

    Article  PubMed  Google Scholar 

  8. Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS (2003) Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry 160:1345–1347

    Article  PubMed  Google Scholar 

  9. Brissos S, Dias VV, Kapczinski F (2008) Cognitive performance and quality of life in bipolar disorder. Can J Psychiatry 53:517–524

    PubMed  Google Scholar 

  10. Brotman MA, Rooney MH, Skup M, Pine DS, Leibenluft E (2009) Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members. J Am Acad Child Adolesc Psychiatry 48:628–635

    Article  PubMed  Google Scholar 

  11. Brotman MA, Schmajuk M, Rich BA, Dickstein DP, Guyer AE, Costello EJ, Egger HL, Angold A, Pine DS, Leibenluft E (2006) Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Biol Psychiatry 60:991–997

    Article  PubMed  Google Scholar 

  12. Burdick KE, Gunawardane N, Woodberry K, Malhotra AK (2009) The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders. Cogn Neuropsychiatry 14:299–311

    Article  PubMed  Google Scholar 

  13. Cahill CM, Walter G, Malhi GS (2009) Neurocognition in bipolar disorder and juvenile bipolar disorder. J Can Acad Child Adolesc Psychiatry 18:221–230

    PubMed  Google Scholar 

  14. Carrus D, Christodoulou T, Hadjulis M, Haldane M, Galea A, Koukopoulos A, Kumari V, Frangou S (2009) Gender differences in immediate memory in bipolar disorder. Psychol Med:1–7

  15. Castillo M, Kwock L, Courvoisie H, Hooper SR (2000) Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. AJNR Am J Neuroradiol 21:832–838

    PubMed  CAS  Google Scholar 

  16. Deckersbach T, Nierenberg AA, Kessler R, Lund HG, Ametrano RM, Sachs G, Rauch SL, Dougherty D (2009) Cognitive Rehabilitation for Bipolar Disorder: an Open Trial for Employed Patients with Residual Depressive Symptoms. CNS Neurosci Ther

  17. DelBello MP, Adler CM, Amicone J, Mills NP, Shear PK, Warner J, Strakowski SM (2004) Parametric neurocognitive task design: a pilot study of sustained attention in adolescents with bipolar disorder. J Affect Disord 82(Suppl 1):S79–S88

    Article  PubMed  Google Scholar 

  18. Dickstein DP, Nelson EE, McClure EB, Grimley ME, Knopf L, Brotman MA, Rich BA, Pine DS, Leibenluft E (2007) Cognitive flexibility in phenotypes of pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 46:341–355

    Article  PubMed  Google Scholar 

  19. Dickstein DP, Rich BA, Roberson-Nay R, Berghorst L, Vinton D, Pine DS, Leibenluft E (2007) Neural activation during encoding of emotional faces in pediatric bipolar disorder. Bipolar Disord 9:679–692

    Article  PubMed  Google Scholar 

  20. Dickstein DP, Treland JE, Snow J, McClure EB, Mehta MS, Towbin KE, Pine DS, Leibenluft E (2004) Neuropsychological performance in pediatric bipolar disorder. Biol Psychiatry 55:32–39

    Article  PubMed  Google Scholar 

  21. Doyle AE, Wilens TE, Kwon A, Seidman LJ, Faraone SV, Fried R, Swezey A, Snyder L, Biederman J (2005) Neuropsychological functioning in youth with bipolar disorder. Biol Psychiatry 58:540–548

    Article  PubMed  Google Scholar 

  22. Doyle AE, Wozniak J, Wilens TE, Henin A, Seidman LJ, Petty C, Fried R, Gross LM, Faraone SV, Biederman J (2009) Neurocognitive impairment in unaffected siblings of youth with bipolar disorder. Psychol Med 39:1253–1263

    Article  PubMed  CAS  Google Scholar 

  23. Duffy A, Alda M, Hajek T, Sherry SB, Grof P (2009) Early stages in the development of bipolar disorder. J Affect Disord

  24. Ernst M, Dickstein DP, Munson S, Eshel N, Pradella A, Jazbec S, Pine DS, Leibenluft E (2004) Reward-related processes in pediatric bipolar disorder: a pilot study. J Affect Disord 82(Suppl 1):S89–S101

    Article  PubMed  Google Scholar 

  25. Fisher M, Holland C, Subramaniam K, Vinogradov S (2009) Neuroplasticity-Based Cognitive Training in Schizophrenia: An Interim Report on the Effects 6 Months Later. Schizophr Bull

  26. Geller B, Tillman R, Bolhofner K, Zimerman B (2008) Child bipolar I disorder: prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome. Arch Gen Psychiatry 65:1125–1133

    Article  PubMed  Google Scholar 

  27. Glahn DC, Bearden CE, Barguil M, Barrett J, Reichenberg A, Bowden CL, Soares JC, Velligan DI (2007) The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry 62:910–916

    Article  PubMed  Google Scholar 

  28. Glahn DC, Bearden CE, Caetano S, Fonseca M, Najt P, Hunter K, Pliszka SR, Olvera RL, Soares JC (2005) Declarative memory impairment in pediatric bipolar disorder. Bipolar Disord 7:546–554

    Article  PubMed  Google Scholar 

  29. Gorlyn M, Keilp JG, Grunebaum MF, Taylor BP, Oquendo MA, Bruder GE, Stewart JW, Zalsman G, Mann JJ (2008) Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects. J Neural Transm 115:1213–1219

    Article  PubMed  Google Scholar 

  30. Gorrindo T, Blair RJ, Budhani S, Dickstein DP, Pine DS, Leibenluft E (2005) Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. Am J Psychiatry 162:1975–1977

    Article  PubMed  Google Scholar 

  31. Guyer AE, McClure EB, Adler AD, Brotman MA, Rich BA, Kimes AS, Pine DS, Ernst M, Leibenluft E (2007) Specificity of facial expression labeling deficits in childhood psychopathology. J Child Psychol Psychiatry 48:863–871

    Article  PubMed  Google Scholar 

  32. Harvey PD, Wingo AP, Burdick KE, Baldessarini RJ (2010) Cognition and disability in bipolar disorder: lessons from schizophrenia research. Bipolar Disord 12:364–375

    Article  PubMed  Google Scholar 

  33. Henin A, Mick E, Biederman J, Fried R, Hirshfeld-Becker DR, Micco JA, Miller KG, Rycyna CC, Wozniak J (2009) Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth? J Clin Psychiatry 70:1178–1185

    Article  PubMed  Google Scholar 

  34. Henin A, Mick E, Biederman J, Fried R, Wozniak J, Faraone SV, Harrington K, Davis S, Doyle AE (2007) Can bipolar disorder-specific neuropsychological impairments in children be identified? J Consult Clin Psychol 75:210–220

    Article  PubMed  Google Scholar 

  35. Hill SK, Harris MS, Herbener ES, Pavuluri M, Sweeney JA (2008) Neurocognitive allied phenotypes for schizophrenia and bipolar disorder. Schizophr Bull 34:743–759

    Article  PubMed  Google Scholar 

  36. Holtmann M, Buchmann AF, Esser G, Schmidt MH, Banaschewski T, Laucht M (2011) The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis. J Child Psychol Psychiatry 52:139–147

    Article  PubMed  Google Scholar 

  37. Holtmann M, Goth K, Wockel L, Poustka F, Bolte S (2008) CBCL-pediatric bipolar disorder phenotype: severe ADHD or bipolar disorder? J Neural Transm 115:155–161

    Article  PubMed  CAS  Google Scholar 

  38. Hsiao YL, Wu YS, Wu JY, Hsu MH, Chen HC, Lee SY, Lee IH, Yeh TL, Yang YK, Ko HC, Lu RB (2009) Neuropsychological functions in patients with bipolar I and bipolar II disorder. Bipolar Disord 11:547–554

    Article  PubMed  Google Scholar 

  39. Jaideep T, Reddy YC, Srinath S (2006) Comorbidity of attention deficit hyperactivity disorder in juvenile bipolar disorder. Bipolar Disord 8:182–187

    Article  PubMed  CAS  Google Scholar 

  40. Joseph MF, Frazier TW, Youngstrom EA, Soares JC (2008) A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder. J Child Adolesc Psychopharmacol 18:595–605

    Article  PubMed  Google Scholar 

  41. Klingberg T, Fernell E, Olesen PJ, Johnson M, Gustafsson P, Dahlstrom K, Gillberg CG, Forssberg H, Westerberg H (2005) Computerized training of working memory in children with ADHD–a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 44:177–186

    Article  PubMed  Google Scholar 

  42. Kowatch RA, Youngstrom EA, Danielyan A, Findling RL (2005) Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord 7:483–496

    Article  PubMed  Google Scholar 

  43. Kraepelin E (ed) (1915) Psychiatrie. Ein Lehrbuch für Studierende und Ärzte. Barth Verlag Leipzig

  44. Kucyi A, Alsuwaidan MT, Liauw SS, McIntyre RS (2010) Aerobic physical exercise as a possible treatment for neurocognitive dysfunction in bipolar disorder. Postgrad Med 122:107–116

    Article  PubMed  Google Scholar 

  45. Kurtz MM, Gerraty RT (2009) A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state. Neuropsychology 23:551–562

    Article  PubMed  Google Scholar 

  46. Kyte ZA, Carlson GA, Goodyer IM (2006) Clinical and neuropsychological characteristics of child and adolescent bipolar disorder. Psychol Med 36:1197–1211

    Article  PubMed  Google Scholar 

  47. Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS (2003) Defining clinical phenotypes of juvenile mania. Am J Psychiatry 160:430–437

    Article  PubMed  Google Scholar 

  48. Lish JD, Dime-Meenan S, Whybrow PC, Price RA, Hirschfeld RM (1994) The National Depressive and Manic-depressive Association (DMDA) survey of bipolar members. J Affect Disord 31:281–294

    Article  PubMed  CAS  Google Scholar 

  49. MacCabe JH, Lambe MP, Cnattingius S, Sham PC, David AS, Reichenberg A, Murray RM, Hultman CM (2010) Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study. Br J Psychiatry 196:109–115

    Article  PubMed  Google Scholar 

  50. Maziade M, Rouleau N, Gingras N, Boutin P, Paradis ME, Jomphe V, Boutin J, Letourneau K, Gilbert E, Lefebvre AA, Dore MC, Marino C, Battaglia M, Merette C, Roy MA (2009) Shared neurocognitive dysfunctions in young offspring at extreme risk for schizophrenia or bipolar disorder in eastern quebec multigenerational families. Schizophr Bull 35:919–930

    Article  PubMed  Google Scholar 

  51. McCarthy J, Arrese D, McGlashan A, Rappaport B, Kraseski K, Conway F, Mule C, Tucker J (2004) Sustained attention and visual processing speed in children and adolescents with bipolar disorder and other psychiatric disorders. Psychol Rep 95:39–47

    PubMed  Google Scholar 

  52. McCarthy J, Kraseski K, Schvartz I, Mercado V, Daisy N, Tobing L, Ryan E (2005) Sustained attention, visual processing speed, and IQ in children and adolescents with Schizophrenia Spectrum disorder and Psychosis Not Otherwise Specified. Percept Mot Skills 100:1097–1106

    PubMed  Google Scholar 

  53. McClure EB, Treland JE, Snow J, Dickstein DP, Towbin KE, Charney DS, Pine DS, Leibenluft E (2005) Memory and learning in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 44:461–469

    Article  PubMed  Google Scholar 

  54. McClure EB, Treland JE, Snow J, Schmajuk M, Dickstein DP, Towbin KE, Charney DS, Pine DS, Leibenluft E (2005) Deficits in social cognition and response flexibility in pediatric bipolar disorder. Am J Psychiatry 162:1644–1651

    Article  PubMed  Google Scholar 

  55. Meyer SE, Carlson GA, Wiggs EA, Martinez PE, Ronsaville DS, Klimes-Dougan B, Gold PW, Radke-Yarrow M (2004) A prospective study of the association among impaired executive functioning, childhood attentional problems, and the development of bipolar disorder. Dev Psychopathol 16:461–476

    Article  PubMed  Google Scholar 

  56. Miklowitz DJ, Chang KD (2008) Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations. Dev Psychopathol 20:881–897

    Article  PubMed  Google Scholar 

  57. Moreno C, Laje G, Blanco C, Jiang H, Schmidt AB, Olfson M (2007) National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch Gen Psychiatry 64:1032–1039

    Article  PubMed  Google Scholar 

  58. Olvera RL, Semrud-Clikeman M, Pliszka SR, O’Donnell L (2005) Neuropsychological deficits in adolescents with conduct disorder and comorbid bipolar disorder: a pilot study. Bipolar Disord 7:57–67

    Article  PubMed  Google Scholar 

  59. Pavuluri MN, O’Connor MM, Harral EM, Moss M, Sweeney JA (2006) Impact of neurocognitive function on academic difficulties in pediatric bipolar disorder: a clinical translation. Biol Psychiatry 60:951–956

    Article  PubMed  Google Scholar 

  60. Pavuluri MN, O’Connor MM, Harral EM, Sweeney JA (2008) An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Res 162:244–255

    Article  PubMed  Google Scholar 

  61. Pavuluri MN, Passarotti AM, Harral EM, Sweeney JA (2009) An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 48:308–319

    Article  PubMed  Google Scholar 

  62. Pavuluri MN, Schenkel LS, Aryal S, Harral EM, Hill SK, Herbener ES, Sweeney JA (2006) Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients. Am J Psychiatry 163:286–293

    Article  PubMed  Google Scholar 

  63. Pavuluri MN, West A, Hill SK, Jindal K, Sweeney JA (2009) Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths. J Am Acad Child Adolesc Psychiatry 48:299–307

    Article  PubMed  Google Scholar 

  64. Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, Bowden CL, Sachs GS, Nierenberg AA (2004) Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 55:875–881

    Article  PubMed  Google Scholar 

  65. Rau G, Blair KS, Berghorst L, Knopf L, Skup M, Luckenbaugh DA, Pine DS, Blair RJ, Leibenluft E (2008) Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation. J Child Adolesc Psychopharmacol 18:185–196

    Article  PubMed  Google Scholar 

  66. Rich BA, Grimley ME, Schmajuk M, Blair KS, Blair RJ, Leibenluft E (2008) Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation. Dev Psychopathol 20:529–546

    Article  PubMed  Google Scholar 

  67. Rich BA, Vinton DT, Roberson-Nay R, Hommer RE, Berghorst LH, McClure EB, Fromm SJ, Pine DS, Leibenluft E (2006) Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proc Natl Acad Sci USA 103:8900–8905

    Article  PubMed  CAS  Google Scholar 

  68. Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN, Moore PB (2006) A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord 93:105–115

    Article  PubMed  Google Scholar 

  69. Rucklidge JJ (2006) Impact of ADHD on the neurocognitive functioning of adolescents with bipolar disorder. Biol Psychiatry 60:921–928

    Article  PubMed  Google Scholar 

  70. Seidman LJ, Giuliano AJ, Smith CW, Stone WS, Glatt SJ, Meyer E, Faraone SV, Tsuang MT, Cornblatt B (2006) Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies. Schizophr Bull 32:507–524

    Article  PubMed  Google Scholar 

  71. Shiratsuchi T, Takahashi N, Suzuki T, Abe K (2000) Depressive episodes of bipolar disorder in early teenage years: changes with increasing age and the significance of IQ. J Affect Disord 58:161–166

    Article  PubMed  CAS  Google Scholar 

  72. Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, Browndyke JN, Sherwood A (2010) Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med 72:239–252

    Article  PubMed  Google Scholar 

  73. Tabares-Seisdedos R, Balanza-Martinez V, Sanchez-Moreno J, Martinez-Aran A, Salazar-Fraile J, Selva-Vera G, Rubio C, Mata I, Gomez-Beneyto M, Vieta E (2008) Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. J Affect Disord 109:286–299

    Article  PubMed  Google Scholar 

  74. Twamley EW, Jeste DV, Bellack AS (2003) A review of cognitive training in schizophrenia. Schizophr Bull 29:359–382

    PubMed  Google Scholar 

  75. Voelbel GT, Bates ME, Buckman JF, Pandina G, Hendren RL (2006) Caudate nucleus volume and cognitive performance: Are they related in childhood psychopathology? Biol Psychiatry 60:942–950

    Article  PubMed  Google Scholar 

  76. Wingo AP, Harvey PD, Baldessarini RJ (2009) Neurocognitive impairment in bipolar disorder patients: functional implications. Bipolar Disord 11:113–125

    Article  PubMed  Google Scholar 

  77. Wingo AP, Wingo TS, Harvey PD, Baldessarini RJ (2009) Effects of lithium on cognitive performance: a meta-analysis. J Clin Psychiatry 70:1588–1597

    Article  PubMed  CAS  Google Scholar 

  78. Youngstrom EA, Freeman AJ, Jenkins MM (2009) The assessment of children and adolescents with bipolar disorder. Child Adolesc Psychiatr Clin N Am 18:353–390, viii-ix

    Google Scholar 

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Acknowledgments

The author would like to thank Colleen M. Schmitz and Douglas A. Orsini for their help with the manuscript.

Conflict of interest

Karin Horn: has no conflicts of interest to disclose. Veit Roessner: has received lecture fees from Eli Lilly, Janssen-Cilag, Medice, Novartis; was member of advisory boards of Eli Lilly, Novartis. Martin Holtmann: has received speaker bench fees from Lilly, Astra Zeneca, Novartis, Shire, Bristol-Myers Squibb and Neuroconn; was member of advisory boards of Lilly, Novartis and Bristol-Myers Squibb and consultancy of Astra Zeneca; has received a research grant from German Research Federation.

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  1. Department of Child and Adolescent Psychiatry/Psychotherapy, University of Dresden, Germany, Fetscherstraße 74, 01307, Dresden, Germany

    Karin Horn & Veit Roessner

  2. LWL-University Hospital for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Ruhr University Bochum, Bochum, Germany

    Martin Holtmann

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  1. Karin Horn
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Correspondence to Karin Horn.

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Horn, K., Roessner, V. & Holtmann, M. Neurocognitive performance in children and adolescents with bipolar disorder: a review. Eur Child Adolesc Psychiatry 20, 433–450 (2011). https://doi.org/10.1007/s00787-011-0209-x

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