European Child & Adolescent Psychiatry

, Volume 15, Issue 6, pp 329–335

Treatment of ADHD with French maritime pine bark extract, Pycnogenol®

  • Jana Trebatická
  • Soňa Kopasová
  • Zuzana Hradečná
  • Kamil Činovský
  • Igor Škodáček
  • Ján Šuba
  • Jana Muchová
  • Ingrid Žitňanová
  • Iweta Waczulíková
  • Peter Rohdewald
  • Zdeňka Ďuračková
ORIGINAL CONTRIBUTION

DOI: 10.1007/s00787-006-0538-3

Cite this article as:
Trebatická, J., Kopasová, S., Hradečná, Z. et al. Eur Child Adolesc Psychiatry (2006) 15: 329. doi:10.1007/s00787-006-0538-3

Abstract

Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in children. Pycnogenol®, an extract from the bark of the French maritime pine, consisting of phenolic acids, catechin, taxifolin and procyanidins, has shown improvement of ADHD in case reports and in an open study. Aim of the present study was to evaluate the effect of Pycnogenol® on ADHD symptoms. Sixty-one children were supplemented with 1 mg/kg/day Pycnogenol® or placebo over a period of 4 weeks in a randomised, placebo-controlled, doubleblind study. Patients were examined at start of trial, 1 month after treatment and 1 month after end of treatment period by standard questionnaires: CAP (Child Attention Problems) teacher rating scale, Conner’s Teacher Rating Scale (CTRS), the Conner’s Parent Rating Scale (CPRS) and a modified Wechsler Intelligence Scale for children. Results show that 1-month Pycnogenol® administration caused a significant reduction of hyperactivity, improves attention and visual–motoric coordination and concentration of children with ADHD. In the placebo group no positive effects were found. One month after termination of Pycnogenol® administration a relapse of symptoms was noted. Our results point to an option to use Pycnogenol as a natural supplement to relieve ADHD symptoms of children.

Keywords

inattention hyperactivity ADHD Pycnogenol® 

Abbreviations

BMI:

body mass index

CAP:

Child Attention Problems

CPRS:

The Conner’s Parent Rating Scale

CTRS:

The Conner’s Teacher rating Scale

ICD-10:

International Statistical Classification of Diseases and Related Health Problems

PDW:

Prague Wechsler Intelligence Scale for children

WISC:

Wechsler Intelligence Scale for children

Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  • Jana Trebatická
    • 1
  • Soňa Kopasová
    • 1
  • Zuzana Hradečná
    • 1
  • Kamil Činovský
    • 1
  • Igor Škodáček
    • 1
  • Ján Šuba
    • 1
  • Jana Muchová
    • 2
  • Ingrid Žitňanová
    • 2
  • Iweta Waczulíková
    • 3
  • Peter Rohdewald
    • 4
  • Zdeňka Ďuračková
    • 2
  1. 1.Dept. of Child Psychiatry, Child University Hospital, Faculty of MedicineComenius UniversityBratislavaSlovakia
  2. 2.Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of MedicineComenius UniversityBratislavaSlovakia
  3. 3.Dept. of Nuclear Physics and Biophysics, Division of Biomedical Physics, Faculty of Mathematics, Physics and InformaticsComenius UniversityBratislavaSlovakia
  4. 4.Institute of Pharmaceutical ChemistryUniversity of MünsterMünsterGermany

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