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Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial

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Abstract

Objectives

The aim of this study was to evaluate the effect of a gel containing green tea extract and hyaluronic acid (HA) on pain scores and wound healing in donor sites after free gingival graft (FGG).

Materials and methods

Forty-two patients requiring FGG were included in three groups: (1) control group (n = 14), no material was placed in the donor area; only the clot was kept in position by sutures; (2) placebo group (n = 14), vehicle gel applied 3 times a day for 7 days; and (3) test group (n = 14), gel containing green tea extract and HA applied 3 times a day for 7 days. The wound size by clinical measurement (WS-CM) and photographic image (WS-PI), complete wound epithelialization (CWE), and palatal mucosa color were evaluated after 3 days and 1, 2, and 4 weeks postoperatively. The visual analog scale (VAS) for pain and analgesic consumption were used to assess participant’s perception in the same postoperative periods.

Results

A similar progressive reduction in the wound size, associated with an improvement in the color pattern, was observed in all groups (p > 0.05). No significant differences were found for CWE and pain assessment between the examined groups (p > 0.05).

Conclusion

The gel containing green tea extract and HA application in palatal wounds after FGG removal does not provide clinical healing benefits using this investigated protocol.

Clinical relevance

This is the first clinical study evaluating the effect of gel containing green tea extract and HA on the palate postoperative pain control and wound healing after FGG.

Trial registration

http://clinicaltrials.gov: NCT05270161

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Funding

We declare the support received from the following funding agencies: CAPES (Coordination for the Improvement of Higher Level or Education Personnel; master’s scholarship) and FAPEMIG (Foundation for Research Support of Minas Gerais).

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Author notes

  1. Jovânia Alves Oliveira and Marcela Iunes da Silveira contributed equally

Authors and Affiliations

  1. School of Dentistry, Alfenas Federal University (Unifal-MG), Alfenas, Minas Gerais, Brazil

    Jovânia Alves Oliveira & Marcela Iunes da Silveira

  2. Department of Periodontology and Implantodontology, School of Dentistry, Federal University of Uberlandia-UFU, School of Dentistry, Umuarama Campus, Bloco UMU4L, Pará Avenue, 1720, Uberlandia, MG, 38405-320, Brazil

    Roberta de Oliveira Alves, Guilherme José Pimentel Lopes de Oliveira & Suzane Cristina Pigossi

  3. São Paulo State University, Botucatu, Brazil

    Fábio José Barbosa Bezerra

Authors
  1. Jovânia Alves Oliveira
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  2. Marcela Iunes da Silveira
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  3. Roberta de Oliveira Alves
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  4. Fábio José Barbosa Bezerra
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  5. Guilherme José Pimentel Lopes de Oliveira
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  6. Suzane Cristina Pigossi
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Contributions

All authors contributed to the study’s conception and design. Material preparation and data collection were performed by Jovânia Alves Oliveira, Marcela Iunes da Silveira Roberta de Oliveira Alves and Suzane Cristina Pigossi. The analysis was made by Guilherme José Pimentel de Oliveira and Fábio José Barbosa Bezerra. The first draft of the manuscript was written by Jovânia Alves Oliveira and Suzane Cristina Pigossi. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Suzane Cristina Pigossi.

Ethics declarations

Ethics approval and consent to publish

The study was approved by the Ethics Committee of the Alfenas Federal University (CAAE: 45014621.2.0000.5142) and Uberlandia Federal University (CAAE: 45014621.2.3001.5152). All 42 selected patients gave full written informed consent following Helsinki Declaration.

Conflict of interest

Dr. Bezerra is associated as a CEO of the Nem Dental Care. The New dental Care donate the gels used in this study.

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Oliveira, J.A., da Silveira, M.I., de Oliveira Alves, R. et al. Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial. Clin Oral Invest 27, 6735–6746 (2023). https://doi.org/10.1007/s00784-023-05282-x

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